Zobrazeno 1 - 10
of 149
pro vyhledávání: '"S Fear"'
Autor:
Nicole C. Shaw, Kevin Chen, Kathryn O. Farley, Mitchell Hedges, Catherine Forbes, Gareth Baynam, Timo Lassmann, Vanessa S. Fear
Publikováno v:
Molecular Autism, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Background SETBP1 Haploinsufficiency Disorder (SETBP1-HD) is characterised by mild to moderate intellectual disability, speech and language impairment, mild motor developmental delay, behavioural issues, hypotonia, mild facial dysmorphisms,
Externí odkaz:
https://doaj.org/article/12a81379ba3148f99409d98a514ee63e
Autor:
Joel Kidman, Rachael M. Zemek, John-William Sidhom, Debora Correa, Nicola Principe, Fezaan Sheikh, Vanessa S. Fear, Catherine A. Forbes, Abha Chopra, Louis Boon, Ayham Zaitouny, Emma de Jong, Robert A. Holt, Matt Jones, Michael J. Millward, Timo Lassmann, Alistair R.R. Forrest, Anna K. Nowak, Mark Watson, Richard A. Lake, W. Joost Lesterhuis, Jonathan Chee
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
Immune checkpoint therapy (ICT) causes durable tumour responses in a subgroup of patients, but it is not well known how T cell receptor beta (TCRβ) repertoire dynamics contribute to the therapeutic response. Using murine models that exclude variatio
Externí odkaz:
https://doaj.org/article/f60545e051804f9796499b61db90824e
Autor:
Wee Loong Chin, Rachael M. Zemek, Caitlin M. Tilsed, Alistair R. R. Forrest, Vanessa S. Fear, Catherine Forbes, Louis Boon, Anthony Bosco, Belinda B. Guo, Michael J. Millward, Anna K. Nowak, Richard A. Lake, W. Joost Lesterhuis, Timo Lassmann
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-9 (2024)
Abstract Time-critical transcriptional events in the immune microenvironment are important for response to immune checkpoint blockade (ICB), yet these events are difficult to characterise and remain incompletely understood. Here, we present whole tum
Externí odkaz:
https://doaj.org/article/a6b9ffd96f4e40b6b71f12cbc7e2efb8
Autor:
Vanessa S. Fear, Catherine A. Forbes, Nicole C. Shaw, Kathryn O. Farley, Jessica L. Mantegna, Jasmin P. Htun, Genevieve Syn, Helena Viola, Henrietta Cserne Szappanos, Livia Hool, Michelle Ward, Gareth Baynam, Timo Lassmann
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Background Genomic sequencing in congenital heart disease (CHD) patients often discovers novel genetic variants, which are classified as variants of uncertain significance (VUS). Functional analysis of each VUS is required in specialised lab
Externí odkaz:
https://doaj.org/article/49a28e30727a4fc5a4c6a4dea486bcd8
Autor:
Kathryn O. Farley, Catherine A. Forbes, Nicole C. Shaw, Emma Kuzminski, Michelle Ward, Gareth Baynam, Timo Lassmann, Vanessa S. Fear
Publikováno v:
HGG Advances, Vol 5, Iss 1, Pp 100257- (2024)
Summary: An estimated 3.5%–5.9% of the global population live with rare diseases, and approximately 80% of these diseases have a genetic cause. Rare genetic diseases are difficult to diagnose, with some affected individuals experiencing diagnostic
Externí odkaz:
https://doaj.org/article/05ebced0f70c428089b7189aa4addd42
Autor:
Rachael M. Zemek, Wee Loong Chin, Vanessa S. Fear, Ben Wylie, Thomas H. Casey, Cath Forbes, Caitlin M. Tilsed, Louis Boon, Belinda B. Guo, Anthony Bosco, Alistair R. R. Forrest, Michael J. Millward, Anna K. Nowak, Richard A. Lake, Timo Lassmann, W. Joost Lesterhuis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Immune checkpoint blockade (ICB) is partially successful as a cancer therapy. Here using mouse models, the authors transcriptionally monitor responding and non-responding tumours showing that responding tumours were associated with transient IFN-β s
Externí odkaz:
https://doaj.org/article/59cfc35dd0fb4aa0a34e44f36234b216
Autor:
Sofina Begum, Blair Z. Johnson, Aude-Claire Morillon, Rongchang Yang, Sze How Bong, Luke Whiley, Nicola Gray, Vanessa S. Fear, Leila Cuttle, Andrew J. A. Holland, Jeremy K. Nicholson, Fiona M. Wood, Mark W. Fear, Elaine Holmes
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract A growing body of evidence supports the concept of a systemic response to non-severe thermal trauma. This provokes an immunosuppressed state that predisposes paediatric patients to poor recovery and increased risk of secondary morbidity. In
Externí odkaz:
https://doaj.org/article/bd738ef484744b0d99df495bd98504fa
Autor:
Sofina Begum, Samantha Lodge, Drew Hall, Blair Z. Johnson, Sze How Bong, Luke Whiley, Nicola Gray, Vanessa S. Fear, Mark W. Fear, Elaine Holmes, Fiona M. Wood, Jeremy K. Nicholson
Publikováno v:
Frontiers in Public Health, Vol 11 (2023)
IntroductionBurn injury in children causes prolonged systemic effects on physiology and metabolism leading to increased morbidity and mortality, yet much remains undefined regarding the metabolic trajectory towards specific health outcomes.MethodsA m
Externí odkaz:
https://doaj.org/article/4f97c39a6f6c4832aeb66d011d4f13e4
Autor:
Vanessa S. Fear, Catherine A. Forbes, Denise Anderson, Sebastian Rauschert, Genevieve Syn, Nicole Shaw, Sarra Jamieson, Michelle Ward, Gareth Baynam, Timo Lassmann
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-15 (2022)
Abstract Background Over 400 million people worldwide are living with a rare disease. Next Generation Sequencing (NGS) identifies potential disease causative genetic variants. However, many are identified as variants of uncertain significance (VUS) a
Externí odkaz:
https://doaj.org/article/abeada057df24630a66a292be29cabef
Autor:
Katherine M. Audsley, Teagan Wagner, Clara Ta, Hannah V. Newnes, Anthony C. Buzzai, Samantha A. Barnes, Ben Wylie, Jesse Armitage, Tsuneyasu Kaisho, Anthony Bosco, Alison McDonnell, Mark Cruickshank, Vanessa S. Fear, Bree Foley, Jason Waithman
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Cancer vaccination drives the generation of anti-tumor T cell immunity and can be enhanced by the inclusion of effective immune adjuvants such as type I interferons (IFNs). Whilst type I IFNs have been shown to promote cross-priming of T cells, the r
Externí odkaz:
https://doaj.org/article/b56b112c536b49278342654b74c0c736