Interleukin-12 production by human monocytes infected with Mycobacterium tuberculosis: role of phagocytosis

Autor: J M Johnsen, S F Wolf, W H Boom, Derek Sieburth, Scott A. Fulton

Publikováno v: Infection and Immunity. 64:2523-2531

Mycobacterium tuberculosis and its antigens are potent inducers of cytokine expression by mononuclear phagocytes. In this study, the ability of live M. tuberculosis to stimulate interleukin-12 (IL-12) expression by human monocytes was examined. Monoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52571de988e4d404b9f981879599134a
https://doi.org/10.1128/iai.64.7.2523-2531.1996

IL-12 inhibits the production of IL-4 and IL-10 in allergen-specific human CD4+ T lymphocytes

Autor: J D Marshall, H Secrist, R H DeKruyff, S F Wolf, D T Umetsu

Publikováno v: The Journal of Immunology. 155:111-117

IL-12 influences cytokine synthesis in unprimed CD4+ T cells by enhancing IFN-gamma synthesis and enhancing the development of Th1 cells, but its effects upon Ag-primed T cells, which are thought to have relatively fixed cytokine profiles, is less cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a44dbb67e098829c7b6a22904ee866d
https://doi.org/10.4049/jimmunol.155.1.111

IL-12 reverses cytokine and immune abnormalities in Sezary syndrome

Autor: A H Rook, M Kubin, M Cassin, E C Vonderheid, B R Vowels, J T Wolfe, S F Wolf, A Singh, G Trinchieri, S R Lessin

Publikováno v: The Journal of Immunology. 154:1491-1498

Cutaneous T cell lymphoma is a lymphoproliferative disorder typically characterized by skin invasion of clonally derived malignant CD4+ lymphocytes that phenotypically resemble mature Th cells. Sezary syndrome (SzS) represents an advanced form of cut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bbb61bb27e42a58e84d540f0f19b7b91
https://doi.org/10.4049/jimmunol.154.3.1491

19th Sir peter freyer memorial lecture and surgical symposium 16th and 17th September 1994

Autor: D. A. McEvoy, B. Connolly, V. Donohue, D. O’Halpin, H. Rowley, T. P. O’Dywer, C. Timon, J. A. McKeever, M. A. Stokes, J. G. Bannigan, M. J. Early, D. M. Baker, Van-Tam Nguyen, D. Bush, J. Jones, J. B. Bourke, K. S. Cross, G. Durkan, M. Stokes, T. Carroll, T. Gorey, K. O’Malley, D. Mulcahy, D. McCormack, J. McElwain, S. C. Natin, T. N. Walsh, T. P. J. Hennessy, K. Carson, R. Page, W. Blunnie, D. C. Moriarty, R. W. G. Watson, D. M. Bouchier-Hayes, H. Abdih, C. J. Kelly, M. Barry, P. Burke, A. Tanner, D. J. Bouchier-Hayes, T. O’Sullivan, A. F. Horgan, D. H. L. Chin, J. A. Mannick, M. L. Rodrick, N. Finnegan, S. T. O’Sullivan, S. F. Wolf, M. C. Barry, C. Condron, R. G. K. Watson, J. D. Evans, C. A. Maxwell-Armstrong, M. K. Barry, K. K. Singh, P. Ralston, C. D. Auld, M. Henderson, J. McCormick, A. D. F. Walls, I. Keogh, M. Kerin, D. O’Hanlon, S. Walsh, P. Kent, J. Callaghan, H. F. Given, P. Madhavan, B. Golden, F. Khan, E. Murphy, N. Couse, G. Burke, P. V. Delaney, R. McLoughlin, P. Kenny, D . O’Hanlon, H. Grimes, S. Reid, P. Neary, M. Nassralla, T. K. Neelamekam, P. Horgan, O. Traynor, P. G. Horgan, J. Hyland, D. M. O’Hanlon, C. O’Boyle, M. J. Duffy, E. W. M. McDermott, D. Reilly, J. J. Fennelly, N. J. O’Higgins, A. McNamara, H. Mullett, D. O’Riordan, E. McDermott, M. Sharp, N. O’Higgins, M. Murphy, M. Little, D. Maher, A. Khalid, P. McCarthy, I. F. Given, C. Bolger, J. P. Phillips, C. Gilligan, S. Zareb, C. Roake, D. S. O’Riordain, D. Farley, C. Grant, J. van Heerden, D. P. O’Brien, M. J. Flynn, F. B. V. Keane, B. Sweeney, D. O’Riordain, A. J. Curran, W. Joyce, D. Smith, H. Gallagher, M. A. Walsh, D. Bouchier-Hayes, J. Phillips, T. O’Brien, S. W. Yusuf, A. C. Perkins, M. Frier, P. W. Wenham, B. R. Hopkinson, G. S. Makin, R. Hind, W. Yusuf, S. C. Whitaker, R. E. Hind, T. A. M. Chuter, G. C. Durkan, M. J. Grenell, M. C. Regan, T. F. Gorey, C. F. Castineira, S. J. Sheehan, M. Wali, M. P. Colgan, D. J. Moore, G. D. Shanik, G. McGreal, J. Kelly, D. Hehir, M. P. Brady, D. M. Sibbering, P. A. M. Holland, A. R. M. Wilson, R. W. Blarney, M. Khurrum Baig, N. Mulligan, B. Farrell, F. O. Cunningham, M. Magd-Eldin, P. Keeling, Y. A. Gul, S. W. Yeo, U. D. Khan, F. Lennon, M. F. Shine, V. Kalidasan, O. Fulena, E. J. Guiney, R. J. Fitzgerald, M. Corbally, A. E. Wood, C. M. Reardon, G. T. McGreal, D. J. Hehir, J. A. O’Donnell, W. O. Kirwan, A. A. Mahomed, A. Keshgar, R. Surna, M. T. Corbally, S. O’Rourke, I. Beckingham, M. C. Bishop, J. Husain, N. Hegarty, J. Calleary, I. Rafi, M. Gilmore, S. M. Saleem, H. P. Singh, T. Aherne, H. P. Redmond, J. McCarthy, D. M. Mulcahy, P. Nicholson, P. Harrington, T. Sharif, H. Smyth, G. Fenelon, J. Pegum, J. Corrigan, A. Jenkinson, A. A. El-Magbri, M. A. Gussail, M. A. Smew, A. Martin, M. Bennett, M. A. Farrell, C. Curran, M. J. Kerin, M. T. P. Caldwell, P. J. Byrne, S. Duggan, A. S. Jones, J. K. Field, D. Monaghan, C. Condren, S. Crerand, M. Kavanagh, P. Dervan, B. Hurson, K. Aiyaswami, D. Evoy, M. Walsh, B. Garrihy, S. Kaf Al-Ghazal, J. O’Donoghue, J. McCann, S. Wagstaff, C. Conroy, M. Dolan, L. Smith, L. Klenerman, J. Noel, V. Waide, D. O’Sullivan, C. Biyani, C. Powell, M. Heal, R. Surana, A. Khan, T. Lynch, T. Sami, W. Baluch, D. Hickey, M. Donovan, P. McLean, D. Murphy, S. Johnston, V. Rastogi, J. Doyle, J. R. Flynn, P. Kelly, M. F. Neligan, S. W. MacGowan, O. Sharkey, A. Bhojwani, C. Barry Walsh, E. Kay, C. Milbum, M. Leader, J. McDermott, D. Moriarty, P. Caushaj, J. M. Fitzpatrick, D. Byrne, W. P. Hederman, N. K. O’Malley, K. H. Chan, P. Fleming, G. C. O’Sullivan, K. Aizaz, A. F. O’Donnell, D. A. Luke, E. M. McGovern, N. Patil, P. Gormley, P. M. McCarthy

Publikováno v: Irish Journal of Medical Science. 163:417-446

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b239240dac64642560bcabf3d83aa7ca
https://doi.org/10.1007/bf02975041

Interleukin 12 at the site of disease in tuberculosis

Autor: S. F. Wolf, Jianhua Gong, M. K. Gately, Ming Zhang, E. Wang, Shuzhuang Lu, Peter F. Barnes, Robert L. Modlin

Publikováno v: Journal of Clinical Investigation. 93:1733-1739

Interleukin 12 (IL-12), a heterodimeric cytokine composed of p40 and p35 chains, has potent immunologic effects in vitro. We used tuberculous pleuritis as a model to study the immunoregulatory potential of IL-12 in vivo at the site of human infectiou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c2f9887fe6fde9362c0151ceec3c682
https://doi.org/10.1172/jci117157