Malignancy without immortality? Cellular immortalization as a possible late event in melanoma progression

Autor: W. Heung Chong, Richard Marais, David M. Kallenberg, S F Hoare, J. W. M. Chow, Dorothy C. Bennett, Rebecca S. Collinson, Carla Milagre, Lucy Hill, Julia K. Soo, Alastair D. MacKenzie Ross, W. Nicol Keith, Mehnaz Hossain

Publikováno v: Pigment Cell & Melanoma Research. 24:490-503

Cell senescence is a permanent growth arrest following extended proliferation. Cultured cancer cells including metastatic melanoma cells often appear immortal (proliferate indefinitely), while uncultured benign nevi (moles) show senescence markers. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::55fed8f19cf6de6eadbe075cf6588bd2
https://doi.org/10.1111/j.1755-148x.2011.00850.x

A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A

Autor: Chunbo Yang, Lyle Armstrong, Irina Neganova, Philip W. Hinds, W. Nicol Keith, Michael J. Cooke, Xin Zhang, Tom Strachan, Miodrag Stojkovic, Majlinda Lako, Owen Hughes, Stefan Przyborski, George Anyfantis, Stefan Fenyk, Stuart P. Atkinson, S F Hoare

Publikováno v: The Journal of Cell Biology

In this study, we show that NANOG, a master transcription factor, regulates S-phase entry in human embryonic stem cells (hESCs) via transcriptional regulation of cell cycle regulatory components. Chromatin immunoprecipitation combined with reporter-b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b42416d98308fa2b10a0631814e0745c
https://doi.org/10.1083/jcb.200801009

Telomerase promoter reprogramming and interaction with general transcription factors in the human mesenchymal stem cell

Autor: S F Hoare, Nedime Serakinci, W. Nicol Keith, Moustapha Kassem, Stuart P. Atkinson

Publikováno v: Serakinci, N, Hoare, S F, Kassem, M, Atkinson, S P & Keith, W N 2006, ' Telomerase promoter reprogramming and interaction with general transcription factors in the human mesenchymal stem cell ', Regenerative Medicine, vol. 1, no. 1, pp. 125-131 . https://doi.org/10.2217/17460751.1.1.125

Udgivelsesdato: Jan The human adult mesenchymal stem cell (hMSC) does not express telomerase and has been shown to be the target for neoplastic transformation after transduction with hTERT. These findings lend support to the stem cell hypothesis of c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702a2ac44243d44b7e024fd2aa55fede
https://doi.org/10.2217/17460751.1.1.125

Lack of Telomerase Gene Expression in Alternative Lengthening of Telomere Cells Is Associated with Chromatin Remodeling of the hTR and hTERT Gene Promoters

Autor: Rosalind Glasspool, Stuart P. Atkinson, W. Nicol Keith, S F Hoare

Publikováno v: Cancer Research. 65:7585-7590

The presence of active telomere maintenance mechanisms in immortal cells allows the bypass of senescence by maintaining telomere length. In most immortal cell lines and tumors, telomere maintenance is attributable to telomerase reactivation. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc5331195237221a796584b07b7a8e95
https://doi.org/10.1158/0008-5472.can-05-1715

A multicentre phase II trial of bryostatin-1 in patients with advanced renal cancer

Autor: Andrew Protheroe, David Propper, Barry W. Hancock, Cheng Han, Srinivasan Madhusudan, Frances R. Balkwill, Adrian L. Harris, Helena M. Earl, Paul A. Vasey, Pippa Corrie, A Turner, S F Hoare

Publikováno v: British Journal of Cancer

Protein kinase C (PKC) has a critical role in several signal transduction pathways, and is involved in renal cancer pathogenesis. Bryostatin-1 modulates PKC activity and has antitumour effects in preclinical studies. We conducted a multicentre phase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::988db3251be1e4bf18f204fe45d2eee7
http://europepmc.org/articles/PMC2394342