Výsledky vyhledávání

Genotype spectrum of ornithine transcarbamylase deficiency: correlation with the clinical and biochemical phenotype

Autor: B A, McCullough, M, Yudkoff, M L, Batshaw, J M, Wilson, S E, Raper, M, Tuchman

Publikováno v: American journal of medical genetics. 93(4)

Ornithine transcarbamylase (OTC) deficiency, a partially dominant X-linked disorder, is the most common inherited defect of the urea cycle. Previous reports suggested a variable phenotypic spectrum, and several studies documented different "private"

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::57ccbd5c600ed4e6bdb9458e666b6409
https://pubmed.ncbi.nlm.nih.gov/10946359

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Acute pancreatitis secondary to dehydration: case report and review of the literature

Autor: S E, Raper

Publikováno v: The American surgeon. 65(11)

Recent reports have documented the potentially catastrophic consequences of dehydration induced by vigorous exercise in otherwise healthy individuals. A case of acute pancreatitis secondary to exercise-induced dehydration is presented, and the litera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::df0cf52692415f5418a0be4a952bb8b4
https://pubmed.ncbi.nlm.nih.gov/10551761

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Cell-biological assessment of human glucokinase mutants causing maturity-onset diabetes of the young type 2 (MODY-2) or glucokinase-linked hyperinsulinaemia (GK-HI)

Autor: C V, Burke, C W, Buettger, E A, Davis, S J, McClane, F M, Matschinsky, S E, Raper

Publikováno v: The Biochemical journal. 342

Mutations in the glucokinase (GK) gene cause type-2 maturity-onset diabetes of the young type 2 (MODY-2) and GK-linked hyperinsulinaemia (GK-HI). Recombinant adenoviruses expressing the human wild-type islet GK or one of four mutant forms of GK, (the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9b7eb0229b17a9d1918dce6e97dd789f
https://pubmed.ncbi.nlm.nih.gov/10455021

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Repeated administration of adenoviral vectors in lungs of human CD4 transgenic mice treated with a nondepleting CD4 antibody

Autor: N, Chirmule, A, Truneh, S E, Haecker, J, Tazelaar, G p, Gao, S E, Raper, J V, Hughes, J M, Wilson

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(1)

The central role of CD4+ T cells in regulation of adenovirus vector-mediated immune responses has been documented previously in murine models. We analyzed the effects of a nondepleting mAb to human CD4 (CD4 mAb; Clenoliximab) on immune functions foll

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c4b584cc2cca7e9716d8d8b770d408e0
https://pubmed.ncbi.nlm.nih.gov/10384148

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Treatment of cirrhotic rats with epidermal growth factor and insulin accelerates liver DNA synthesis after partial hepatectomy

Autor: M, Hashimoto, P C, Kothary, F E, Eckhauser, S E, Raper

Publikováno v: Journal of gastroenterology and hepatology. 13(12)

Prevention of postoperative hepatic failure is important after hepatic resection. In patients with cirrhosis, impaired liver function and regenerative capacity after major hepatic resection are associated with increased morbidity and mortality. In th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ee57dca13901c6376d4867738454c94d
https://pubmed.ncbi.nlm.nih.gov/9918436

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Immunologic barriers to hepatic adenoviral gene therapy for transplantation

Autor: R P, DeMatteo, G, Chu, M, Ahn, E, Chang, C, Burke, S E, Raper, C F, Barker, J F, Markmann

Publikováno v: Transplantation. 63(2)

Adenoviral gene transfer has potential use to attenuate the immunogenicity of hepatic allografts. However, the clinical application of adenoviral gene therapy is currently impeded by the potent host immune response to the virus that limits the durati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::71fb5727889c0b3e89a50b7564e5bd17
https://pubmed.ncbi.nlm.nih.gov/9020337

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Adenoviral-mediated gene transfer to the small intestinal isograft

Autor: T E, Hamilton, S, Koide, W, Zhang, J L, Rombeau, S E, Raper

Publikováno v: Transplantation proceedings. 28(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ebbf98f1b14757063748a7736636b9d3
https://pubmed.ncbi.nlm.nih.gov/8907888

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Prolongation of adenoviral transgene expression in mouse liver by T lymphocyte subset depletion

Autor: R P, DeMatteo, J F, Markmann, K F, Kozarsky, C F, Barker, S E, Raper

Publikováno v: Gene therapy. 3(1)

Although first generation recombinant adenoviruses are efficient vehicles for gene transfer, their immunogenicity precludes long-term persistence. We show that adenoviral transgene expression in the liver of normal mice is prolonged from a baseline o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7d54216427672d2e7d281ef9857e7ac6
https://pubmed.ncbi.nlm.nih.gov/8929906

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Hepatocyte transplantation and gene therapy

Autor: S E, Raper

Publikováno v: Clinical transplantation. 9(3 Pt 2)

Trials of liver-directed gene therapy are a clinical reality. Technology is rapidly developing for the isolation of large numbers of human hepatocytes. Recombinant DNA techniques are available to engineer recombinant retroviruses which express genes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::62691c208d5357c7333d7a8cae18291b
https://pubmed.ncbi.nlm.nih.gov/7670171

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