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A role for TNF-alpha and mucosal T helper-1 cytokines in the pathogenesis of Crohn's disease

Autor: S E Plevy, C J Landers, J Prehn, N M Carramanzana, R L Deem, D Shealy, S R Targan

Publikováno v: The Journal of Immunology. 159:6276-6282

Recent clinical studies of Crohn's disease patients demonstrated dramatic clinical responses following one i.v. infusion of a chimeric mAb to TNF-alpha (cA2). To assess the role of TNF-alpha in mucosal cytokine regulation, the effects of TNF-alpha on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::21971026521fa1c23f2eb7631af72f65
https://doi.org/10.4049/jimmunol.159.12.6276

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Infliximab induces potent anti-inflammatory and local immunomodulatory activity but no systemic immune suppression in patients with Crohn's disease

Autor: F, Cornillie, D, Shealy, G, D'Haens, K, Geboes, G, Van Assche, J, Ceuppens, C, Wagner, T, Schaible, S E, Plevy, S R, Targan, P, Rutgeerts

Publikováno v: Alimentary pharmacologytherapeutics. 15(4)

Anti-TNFalpha therapy with infliximab is effective for Crohn's disease. Infliximab neutralizes the biological activities of TNFalpha, a cytokine involved in host-defence against certain infections.To evaluate the effects of infliximab on the gut and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9eafc3d95ca8072935e9b6295862b9a8
https://pubmed.ncbi.nlm.nih.gov/11736736

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Characterization of an activation protein-1-binding site in the murine interleukin-12 p40 promoter. Demonstration of novel functional elements by a reductionist approach

Autor: C, Zhu, K, Gagnidze, J H, Gemberling, S E, Plevy

Publikováno v: The Journal of biological chemistry. 276(21)

Interleukin (IL)-12 is a heterodimeric cytokine produced by macrophages in response to intracellular pathogens and provides an obligatory signal for the differentiation of T-helper-1 cells. We previously reported an analysis of the IL-12 p40 promoter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fbf089f07c3e47a33208b68db420d60d
https://pubmed.ncbi.nlm.nih.gov/11279072

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Linkage of Crohn's disease to the major histocompatibility complex region is detected by multiple non-parametric analyses

Autor: Jerome I. Rotter, Dolly B. Tyan, Nathan Fischel-Ghodsian, Kent D. Taylor, Colleen McElree, Huiying Yang, Stephan R. Targan, S E Plevy

Publikováno v: Gut. 44(4)

BACKGROUNDThere is evidence for genetic susceptibility to Crohn’s disease, and a tentative association with tumour necrosis factor (TNF) and HLA class II alleles.AIMSTo examine the potential of genetic linkage between Crohn’s disease and the MHC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32096a1a76e919ff6d57fc42cc8dc84f
https://pubmed.ncbi.nlm.nih.gov/10075959

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A role for TNF-alpha and mucosal T helper-1 cytokines in the pathogenesis of Crohn's disease

Autor: S E, Plevy, C J, Landers, J, Prehn, N M, Carramanzana, R L, Deem, D, Shealy, S R, Targan

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 159(12)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3da032bdf54e54eedb6c8f1c59aaeba1
https://pubmed.ncbi.nlm.nih.gov/9550432

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Akademický článek

Hypoxic Exosomal circPLEKHM1‐Mediated Crosstalk between Tumor Cells and Macrophages Drives Lung Cancer Metastasis.

Autor: Wang, Dongliang^1,2,3,4 (AUTHOR), Wang, Shuoer^1,2,3,4,5 (AUTHOR), Jin, Mingming^6,7 (AUTHOR), Zuo, Yan^1,2,3,4 (AUTHOR), Wang, Jianpeng⁸ (AUTHOR), Niu, Ya^1,2 (AUTHOR), Zhou, Qian^1,2 (AUTHOR), Chen, Jiwei^1,2 (AUTHOR), Tang, Xinru^1,2 (AUTHOR), Tang, Wenxuan^1,9 (AUTHOR), Liu, Xiyu^6,7 (AUTHOR), Yu, Hang^1,2 (AUTHOR), Yan, Wangjun^2,5 (AUTHOR), Wei, Huan‐Huan¹⁰ (AUTHOR), Huang, Gang^6,7 (AUTHOR), Song, Shaoli^1,2,3,4 (AUTHOR) shaoli_song@fudan.edu.cn, Tang, Shuang^1,2,11 (AUTHOR) tangshuang@fudan.edu.cn

Publikováno v: Advanced Science. 6/12/2024, Vol. 11 Issue 22, p1-20. 20p.

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Akademický článek

Efficient Recovery of Complete Gut Viral Genomes by Combined Short‐ and Long‐Read Sequencing.

Autor: Chen, Jingchao¹ (AUTHOR), Sun, Chuqing¹ (AUTHOR), Dong, Yanqi² (AUTHOR), Jin, Menglu^1,3 (AUTHOR), Lai, Senying² (AUTHOR), Jia, Longhao² (AUTHOR), Zhao, Xueyang³ (AUTHOR), Wang, Huarui¹ (AUTHOR), Gao, Na L.^1,4 (AUTHOR), Bork, Peer^5,6,7,8 (AUTHOR), Liu, Zhi⁹ (AUTHOR) zhiliu@hust.edu.cn, Chen, Wei‐Hua^1,3,10 (AUTHOR) weihuachen@hust.edu.cn, Zhao, Xing‐Ming^2,11,12,13 (AUTHOR) xmzhao@fudan.edu.cn

Publikováno v: Advanced Science. 4/3/2024, Vol. 11 Issue 13, p1-18. 18p.

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Akademický článek

The Next Generation Fecal Microbiota Transplantation: To Transplant Bacteria or Virome.

Autor: Yu, You^1,2 (AUTHOR), Wang, Weihong^1,2 (AUTHOR), Zhang, Faming^1,2,3 (AUTHOR) fzhang@njmu.edu.cn

Publikováno v: Advanced Science. Dec2023, Vol. 10 Issue 35, p1-17. 17p.

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ELK4 Promotes Colorectal Cancer Progression by Activating the Neoangiogenic Factor LRG1 in a Noncanonical SP1/3‐Dependent Manner.

Autor: Zhu, Zhehui^1,2 (AUTHOR), Guo, Yuegui¹ (AUTHOR), Liu, Yun¹ (AUTHOR), Ding, Rui¹ (AUTHOR), Huang, Zhenyu¹ (AUTHOR), Yu, Wei² (AUTHOR), Cui, Long¹ (AUTHOR), Du, Peng¹ (AUTHOR) dupeng@xinhuamed.com.cn, Goel, Ajay³ (AUTHOR) ajgoel@coh.org, Liu, Chen‐Ying¹ (AUTHOR) liuchenying@xinhuamed.com.cn

Publikováno v: Advanced Science. 11/14/2023, Vol. 10 Issue 32, p1-17. 17p.

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