Zobrazeno 1 - 10
of 30
pro vyhledávání: '"S E Pemble"'
Autor:
Tommaso Vannocci, Nicholas W. Wood, Suran Nethisinghe, Paola Giunti, Serena Faggiano, S E Pemble, Human Rezaei, Mary G. Sweeney, Mary B. Davis, Annalisa Pastore, Rajesh Menon
Publikováno v:
PLoS Genetics
PLoS Genetics, Public Library of Science, 2013, 9 (7), ⟨10.1371/journal.pgen.1003648⟩
PLoS Genetics, Vol 9, Iss 7, p e1003648 (2013)
Plos Genetics 7 (9), . (2013)
PLoS Genetics, Public Library of Science, 2013, 9 (7), ⟨10.1371/journal.pgen.1003648⟩
PLoS Genetics, Vol 9, Iss 7, p e1003648 (2013)
Plos Genetics 7 (9), . (2013)
At least nine dominant neurodegenerative diseases are caused by expansion of CAG repeats in coding regions of specific genes that result in abnormal elongation of polyglutamine (polyQ) tracts in the corresponding gene products. When above a threshold
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04710fa3fc63e9be302acd555799e4d0
https://hal.inrae.fr/hal-02644451
https://hal.inrae.fr/hal-02644451
Autor:
Brian Ketterer, Jennifer Taylor, Ricarda Thier, Harry Kramer, F. Peter Guengerich, S E Pemble
Publikováno v:
Carcinogenesis. 17:163-166
The rat theta class glutathione S-transferase (GST) 5-5 has been shown to affect the mutagenicity of halogenated alkanes and epoxides. In Salmonella typhimurium TA1535 expressing the rat GST5-5 the number of revertants was increased compared to the c
Publikováno v:
Pharmacogenetics. 5:S103-S107
Conjugation of chemicals with glutathione (GSH) can lead to decreased or increased toxicity. A genetic deficiency in the GSH S-transferase mu class gene M1 has been hypothesized to lead to greater risk of lung cancer in smokers. Recently a gene delet
Publikováno v:
Chemical Research in Toxicology. 8:465-472
Recently, we inserted the plasmid vector pKK233-2 containing rat GSH S-transferase (GST) 5-5 cDNA into Salmonella typhimurium TA1535 and found that these bacteria [GST 5-5(+)] expressed the protein and produced mutations when ethylene or methylene di
Autor:
Marios Panas, S E Pemble, Nicholas W. Wood, Georgios Koutsis, Henry Houlden, Athina Kladi, Mary G. Sweeney, Reema Paudel
Publikováno v:
Journal of the neurological sciences. 318(1-2)
The relative frequency of different autosomal dominant cerebellar ataxias, commonly referred to as spinocerebellar ataxias (SCAs), varies considerably among populations of different ethnic origin. No data exist at present on the frequency of differen
Autor:
J B Taylor, S. R. Spencer, Hermann M. Bolt, K R Schroeder, Brian Ketterer, S E Pemble, David J. Meyer, E. Hallier
Publikováno v:
Biochemical Journal. 300:271-276
In humans, glutathione-dependent conjugation of halomethanes is polymorphic, with 60% of the population classed as conjugators and 40% as non-conjugators. We report the characterization of the genetic polymorphism causing the phenotypic difference. W
Autor:
Charles W.E. Redman, Brian Ketterer, Anthony A. Fryer, Richard C. Strange, Peter W. Jones, Adrian Warwick, Julie Alldersea, S E Pemble, J B Taylor, Panos Sarhanis, Janice Gilford, Lilian Yengi
Publikováno v:
Carcinogenesis. 15:2841-2845
The factors that determine progression of cervical intra-epithelial neoplasia (CIN) to squamous cell carcinoma (SCC) are unknown. Cigarette smoking is a risk factor, suggesting polymorphism at loci that encode carcinogen-metabolizing enzymes such as
Autor:
J B Taylor, Brian Ketterer, S E Pemble, Ricarda Thier, Persmark M, W. G. Humphreys, F P Guengerich
Publikováno v:
Proceedings of the National Academy of Sciences. 90:8576-8580
Dihalomethanes can produce liver tumors in mice but not in rats, and concern exists about the risk of these compounds to humans. Glutathione (GSH) conjugation of dihalomethanes has been considered to be a critical event in the bioactivation process,
Autor:
Glen Talaska, S E Pemble, Nicholas P. Lang, J B Taylor, Fred F. Kadlubar, Jonathan M. Harris, David J. Meyer, Brian Ketterer
Publikováno v:
Environmental Health Perspectives
Scopus-Elsevier
Scopus-Elsevier
Cytosolic glutathione S-transferases (GSTs) are a supergene family of dimeric enzymes capable of detoxifying a number of carcinogenic electrophiles. Of the numerous components of tobacco smoke, the polycyclic aromatic hydrocarbons appear to be the pr
Publikováno v:
Biochemical Journal. 284:313-319
A cDNA clone, lambda GTRA8, encoding rat glutathione transferase subunit 8 has been isolated from a lambda gt10 rat hepatoma cDNA library. The previously known amino acid sequence of the enzyme was used to design primers for a polymerase chain reacti