Polarized α-synuclein trafficking and transcytosis across brain endothelial cells via Rab7-decorated carriers

Autor: Parvez Alam, Mikkel R. Holst, Line Lauritsen, Janni Nielsen, Simone S. E. Nielsen, Poul Henning Jensen, Jonathan R. Brewer, Daniel E. Otzen, Morten S. Nielsen

Publikováno v: Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-12 (2022)

Abstract Parkinson’s disease is mainly caused by aggregation of α-synuclein (α-syn) in the brain. Exchange of α-syn between the brain and peripheral tissues could have important pathophysiological and therapeutic implications, but the traffickin

Externí odkaz: https://doaj.org/article/82b4322c12b3489790248a736a110a73

The endo-lysosomal system of bEnd.3 and hCMEC/D3 brain endothelial cells

Autor: Andrea E. Toth, Simone S. E. Nielsen, Weronika Tomaka, N. Joan Abbott, Morten S. Nielsen

Publikováno v: Fluids and Barriers of the CNS, Vol 16, Iss 1, Pp 1-13 (2019)

Abstract Background Brain endothelial cell-based in vitro models are among the most versatile tools in blood–brain barrier research for testing drug penetration to the central nervous system. Transcytosis of large pharmaceuticals across the brain c

Externí odkaz: https://doaj.org/article/a1ffaf25f16c48398ddf963620e6cdf0

Transport of a Peptide from Bovine αs1-Casein across Models of the Intestinal and Blood–Brain Barriers

Autor: Carsten Scavenius, Steen V. Petersen, Morten Nielsen, Jan T. Rasmussen, Andrea E. Tóth, Brian Christensen, Simone S. E. Nielsen, Jan J. Enghild, Esben S. Sørensen

Publikováno v: Nutrients
Volume 12
Issue 10
Christensen, B, Toth, A E, Nielsen, S S E, Scavenius, C, Petersen, S V, Enghild, J J, Rasmussen, J T, Nielsen, M S & Sørensen, E S 2020, ' Transport of a peptide from bovine α s1-casein across models of the intestinal and blood–brain barriers ', Nutrients, vol. 12, no. 10, 3157 . https://doi.org/10.3390/nu12103157
Nutrients, Vol 12, Iss 3157, p 3157 (2020)

The effect of food components on brain growth and development has attracted increasing attention. Milk has been shown to contain peptides that deliver important signals to the brains of neonates and infants. In order to reach the brain, milk peptides

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3abb24a6d1a304118019fae3632d8a26
https://doi.org/10.3390/nu12103157

Alternative Industrial Surface Solutions

Autor: P. T. Nielsen, S. E. Nielsen

Publikováno v: International Thermal Spray Conference.

This paper discusses some of the practical uses of laser cladding and laser fusing in part manufacturing and component repair. It provides an overview of both processes and the types of surfaces they can produce. It presents application examples for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fff5ac6f6bd40282864baccc0bc43275
https://doi.org/10.31399/asm.cp.itsc2016p0522

Genetically based low oxygen affinities of felid hemoglobins: lack of biochemical adaptation to high-altitude hypoxia in the snow leopard

Autor: Jay F. Storz, Angela Fago, Jan E. Janecka, Sidsel D. Andersen, Roy E. Weber, Federico G. Hoffmann, Trevor Anderson, Simone S. E. Nielsen

Publikováno v: Janecka, J E, Nielsen, S S E, Andersen, S D, Hoffmann, F G, Weber, R E, Anderson, T, Storz, J F & Fago, A 2015, ' Genetically based low oxygen affinities of felid hemoglobins: lack of biochemical adaptation to high-altitude hypoxia in the snow leopard ', Journal of Experimental Biology, vol. 218, pp. 2402-2409 . https://doi.org/10.1242/jeb.125369

Genetically based modifications of hemoglobin (Hb) function that increase blood–O2 affinity are hallmarks of hypoxia adaptation in vertebrates. Among mammals, felid Hbs are unusual in that they have low intrinsic O2 affinities and reduced sensitivi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ba135b12d986cfae85910edd0fe909d
https://pure.au.dk/portal/da/publications/genetically-based-low-oxygen-affinities-of-felid-hemoglobins-lack-of-biochemical-adaptation-to-highaltitude-hypoxia-in-the-snow-leopard(0968930a-976a-4263-aad8-de7cb9af9eb1).html