Zobrazeno 1 - 2
of 2
pro vyhledávání: '"S E, Swinler"'
Autor:
S P, Fink, S E, Swinler, J D, Lutterbaugh, J, Massagué, S, Thiagalingam, K W, Kinzler, B, Vogelstein, J K, Willson, S, Markowitz
Publikováno v:
Cancer research. 61(1)
Transforming growth factor-beta (TGF-beta) inhibits growth and induces apoptosis of colon epithelial cells. Binding of TGF-beta to its receptor induces phosphorylation of the Smad proteins Smad2 and Smad3, which then form heteromeric complexes with S
Autor:
W M, Grady, L L, Myeroff, S E, Swinler, A, Rajput, S, Thiagalingam, J D, Lutterbaugh, A, Neumann, M G, Brattain, J, Chang, S J, Kim, K W, Kinzler, B, Vogelstein, J K, Willson, S, Markowitz
Publikováno v:
Cancer research. 59(2)
We previously demonstrated that mutational inactivation of transforming growth factor beta type II receptors (RIIs) is very common among the 13% of human colon cancers with microsatellite instability. These mutations principally cluster in the BAT-RI