Zobrazeno 1 - 10
of 63
pro vyhledávání: '"S E, Pfeiffer"'
Publikováno v:
Journal of Neurochemistry. 72:988-998
Myelin membrane synthesis in the CNS by oligodendrocytes (OLs) involves directed intracellular transport and targeting of copious amounts of specialized lipids and proteins over a relatively short time span. As in other plasma membrane-directed fusio
Autor:
Corinna Lappe-Siefke, W. J. Shoemaker, Matthew N. Rasband, Melissa Bryant, L. Oh, Rashmi Bansal, Miki Furusho, Jennifer M. Rosenbluth, Yoshimi Kaga, David M. Ornitz, Klaus-Armin Nave, Kai Yu, S. E. Pfeiffer
Publikováno v:
The Journal of Neuroscience. 26:12339-12350
Fibroblast growth factor receptors (Fgfr) comprise a widely expressed family of developmental regulators implicated in oligodendrocyte (OL) maturation of the CNS. Fgfr2 is expressed by OLs in myelinated fiber tracks.In vitro, Fgfr2 is highly upregula
Autor:
T. Kim, Susan Winkler, Cecilia B. Marta, Christopher M. Taylor, T. Coetzee, Rashmi Bansal, S. E. Pfeiffer
Publikováno v:
The Journal of Neuroscience. 23:5461-5471
Myelin oligodendrocyte glycoprotein (MOG) is, quantitatively, a relatively minor component of the myelin membrane. Nevertheless, peritoneal administration of MOG evokes potent cellular and humoral immunoreactivity, resulting in an experimental allerg
Publikováno v:
Molecular and Cellular Neuroscience. 18:593-605
Proteolipids are abundant integral membrane proteins, initially described as structural proteins of CNS myelin. More recently, two neuronal proteins related to proteolipid protein (PLP), termed M6A and M6B, were identified, suggesting a common functi
Autor:
S. E. Pfeiffer, Y. Yamaguchi
Publikováno v:
Journal of Neuroscience Research. 56:199-205
Two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) provides high resolution separation of proteins and offers a powerful method for their identification and characterization. Since many myelin-specific proteins are highly basic, they cannot
Publikováno v:
Neurochemical Research. 23:421-426
The transient transfection of transgenes into oligodendrocytes offers an important tool for studying the function of proteins during myelin formation. Currently established procedures, however, have generally resulted in low survival rates and low le
Autor:
S. E. Pfeiffer, Rashmi Bansal
Publikováno v:
Journal of Neuroscience Research. 50:215-228
Fibroblast growth factor (FGF)-2 differentially regulates oligodendrocyte progenitor proliferation and differentiation in culture, and modulates gene expression of its own receptors, in a developmental and receptor type-specific manner (Bansal et al.
Publikováno v:
Journal of Neuroscience Research. 45:258-268
The small GTP-binding protein Rab3a is involved in regulated secretory pathways and is enriched in synaptic and neuroendocrine secretory vesicles. We have reported previously the developmental regulation of Rab3a in oligodendrocytes in culture and pu
Publikováno v:
Molecular and Cellular Neuroscience. 7:263-275
Fibroblast growth factors (FGFs) affect a broad spectrum of developmentally regulated cellular responses involved in the control of growth and differentiation. To identify specific FGF receptor forms involved in these responses, we have characterized
Publikováno v:
Molecular and Cellular Neuroscience. 7:276-288
Differentiating cells undergo developmentally regulated changes in cell-cell and cell-matrix adhesion that control migration through microenvironments, proliferation, and differentiation. The diversity of the patterns of expression of heparan sulfate