Zobrazeno 1 - 10
of 21
pro vyhledávání: '"S E, Murphy"'
Publikováno v:
Journal of Zoology. 288:177-183
Reinstating forestry practices, such as coppicing, thinning the understorey and grazing, has become a key element of proposals for improving the conservation value of broadleaved woodlands in Europe. However, the consequences of such woodland managem
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(6)
Watercress is an excellent source of phenethyl isothiocyanate (PEITC), an effective inhibitor of nitrosamine carcinogenesis in rodents. The mechanism of inhibition is believed to be due in part to inhibition of cytochrome P450 (P450) enzymes. P450 2A
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(11)
N'-nitrosonornicotine (NNN) induces tumors in the rat nasal cavity and esophagus and is believed to be a causative agent for esophageal cancer in tobacco users. To exert its carcinogenic potential, NNN must be metabolically activated by alpha-hydroxy
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(11)
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and its major metabolite, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), are potent lung carcinogens in animals. UGT-mediated O-glucuronidation of NNAL is an important detoxification pathway for t
Publikováno v:
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 8(10)
The effects of watercress consumption on the metabolism of nicotine in smokers were examined. Watercress is a rich source of phenethyl isothiocyanate (PEITC), an effective chemopreventive agent for cancers of the lung and esophagus induced in rodents
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(9)
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and its major metabolite, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), are potent lung carcinogens in animals. UDP-glucuronosyltransferase (UGT)-mediated glucuronidation of NNAL is a potentially
Autor:
S S, Hecht, S G, Carmella, M, Chen, J F, Dor Koch, A T, Miller, S E, Murphy, J A, Jensen, C L, Zimmerman, D K, Hatsukami
Publikováno v:
Cancer research. 59(3)
We quantified urinary levels of two metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in people who had stopped smoking: 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) and its O-glucuronide
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 26(2)
Kinetic parameters were determined for the hydroxylation of N'-nitrosonornicotine (NNN), N-nitrosobenzylmethylamine (NBzMA), coumarin, and ethoxycoumarin catalyzed by rat nasal mucosa microsomes. NNN is a tobacco-specific nitrosamine that, in rats, c
Autor:
M E, Staretz, S E, Murphy, C J, Patten, M G, Nunes, W, Koehl, S, Amin, L A, Koenig, F P, Guengerich, S S, Hecht
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 25(2)
We compared the metabolism in human hepatic microsomes of three tobacco smoke carcinogens believed to be involved in the induction of cancer in humans: benzo[a]pyrene (BaP),4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), and N'-nitrosonomicotin
Publikováno v:
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 5(2)
Exposure to environmental tobacco smoke (ETS) was assessed as part of a pilot study aimed at determining the extent of multiple toxicant exposures in children from inner-city areas of Baltimore, MD. Questionnaire data on sources of ETS and urinary co