Zobrazeno 1 - 8
of 8
pro vyhledávání: '"S E, Hemby"'
Publikováno v:
Journal of autism and developmental disorders. 31(6)
Several studies indicate a primary dysfunction of the temporal lobe in autism, specifically the hippocampal formation and entorhinal cortex (EC). Assessment of gene expression in the EC and hippocampus will provide insight into the subtle alterations
Publikováno v:
Annals of neurology. 48(1)
The pathogenesis of neurofibrillary tangles (NFTs) in Alzheimer's disease (AD) is poorly understood, but changes in the expression of specific messenger RNAs (mRNAs) may reflect mechanisms underlying the formation of NFTs and their consequences in af
Autor:
S D, Ginsberg, P B, Crino, S E, Hemby, J A, Weingarten, V M, Lee, J H, Eberwine, J Q, Trojanowski
Publikováno v:
Annals of neurology. 45(2)
The sequestration of RNA in Alzheimer's disease (AD) senile plaques (SPs) and the production of intraneuronal amyloid-beta peptides (Abeta) prompted analysis of the mRNA profile in single immunocytochemically identified SPs in sections of AD hippocam
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 288(1)
The abuse of cocaine/opiate combinations (speedball) represents a growing trend in illicit drug use. Delineation of neurobiological substrates mediating the reinforcing effects of the combination may increase our knowledge of reinforcement mechanisms
Autor:
S E, Hemby, I, Lucki, G, Gatto, A, Singh, C, Thornley, J, Matasi, N, Kong, J E, Smith, H M, Davies, S I, Dworkin
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 282(2)
The forced swimming test (FST) predicts the efficacy of clinically effective antidepressants. In the present study, using the FST we examined the antidepressant potential of three novel tropane analogs: 8-methyl-2beta-propanoyl-3beta-(4-(1-methylethy
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 277(3)
In the first experiment, responding was maintained for food under a fixed ratio (FR) 10 with a 6-min timeout reinforcement schedule. Eticlopride (0.1-1.0 mg/kg i.p.) dose-dependently decreased the number of food pellets obtained, whereas naltrexone (
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 273(2)
Dopaminergic innervations of the nucleus accumbens (NAcc) have a significant role in the brain processes underlying the reinforcing actions of abused drugs. In addition to the evidence from selective lesions and receptor antagonists, recent determina
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 273(2)
2 beta-propanoyl-3 beta-(4-tolyl) tropane (PTT) is a novel tropane that has been shown to be approximately 20 times more potent than cocaine in binding to the 3 beta-[4'-iodophenyl] tropane-2 beta-carboxylic acid methyl ester (RTI-55) site on the dop