Zobrazeno 1 - 10
of 55
pro vyhledávání: '"S E, Clarke"'
Publikováno v:
Bulletin of Entomological Research. 93:279-287
A study was undertaken to identify the major larval habitats of the Anopheles gambiae (Giles) complex in rural Gambia. Mosquito larvae and pupae were sampled along transects and in specific habitats in the central region of the country during the rai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53b7a52bc0a20023e1c169f071de1fae
https://doi.org/10.1079/ber2003239
https://doi.org/10.1079/ber2003239
Autor:
S. E. Clarke, Christine Beedham, H. Laljee, C. G. M. Jordan, Mohammad-Reza Rashidi, J. E. Brown
Publikováno v:
Journal of Pharmacy and Pharmacology. 51:411-418
Although 7-hydroxymethotrexate is a major metabolite of methotrexate during high-dose therapy, negligible methotrexate-oxidizing activity has been found in-vitro in the liver in man. The goals of this study were to determine the role of aldehyde oxid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13fea4c5583cc21ed1da40160bd67e35
https://doi.org/10.1211/0022357991772619
https://doi.org/10.1211/0022357991772619
Autor:
G. C. Vivian, S. R. Underwood, Elizabeth Prvulovich, Peter H. Jarritt, Dudley J. Pennell, S E Clarke
Publikováno v:
Nuclear Medicine Communications. 19:831-838
The aim of this study was to assess the status of acquisition and reporting of myocardial perfusion tomography in the UK. Centres were asked to provide an expert panel with clinical and technical information, digital and hard copy of raw data and rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6b4d521802b03460307341491794934
https://doi.org/10.1097/00006231-199809000-00003
https://doi.org/10.1097/00006231-199809000-00003
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 22:315-319
An in vitro reporter gene assay has been established to examine cytochrome P4504A1 (CYP4A1) induction. A response element from the upstream region of the rat CYP4A1 gene containing a peroxisome proliferator response element (PPRE) has been linked to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::146ef280f2443656dba602eb2e7cbf84
https://doi.org/10.1007/bf03190963
https://doi.org/10.1007/bf03190963
Publikováno v:
Rapid Communications in Mass Spectrometry. 10:1165-1168
Liquid chromatography with an electrospray ionization (ESI) interface has been applied to study the anticancer drug taxol and its metabolites after incubation with human hepatic microsomes. The parent drug and its metabolites were monitored in the po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::744ccbdcebc986a8789aa92d82aab0ff
https://doi.org/10.1002/(sici)1097-0231(19960731)10:10<1165::aid-rcm608>3.0.co
https://doi.org/10.1002/(sici)1097-0231(19960731)10:10<1165::aid-rcm608>3.0.co
Publikováno v:
Xenobiotica. 25:917-927
1. Caffeine N3-demethylation, the major pathway of caffeine metabolism in man, is mediated by P4501A2. The carbon of the methyl group lost during N3-demethylation is eliminated as carbon dioxide in vivo, or as formaldehyde and formic acid in vitro. 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1093c79c5b9954f579023db7e7d7589d
https://doi.org/10.3109/00498259509046663
https://doi.org/10.3109/00498259509046663
Publikováno v:
British Journal of Clinical Pharmacology. 38:557-566
1. The metabolism of granisetron was investigated in human liver microsomes to identify the specific forms of cytochrome P450 responsible. 2. 7-hydroxy and 9'-desmethyl granisetron were identified as the major products of metabolism following incubat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fd51d46c7ed1ac7e3bba5da19ec371c
https://doi.org/10.1111/j.1365-2125.1994.tb04397.x
https://doi.org/10.1111/j.1365-2125.1994.tb04397.x
Autor:
F. J. Hollis, M. Nash, S. E. Clarke, F. R. Woods, P. C. Shardlow, T. C. Tasker, J. C. Bloomer, R. E. Haddock, G. D. Allen, N. E. Austin, F. C. Higham
Publikováno v:
Xenobiotica. 24:1119-1131
1. The disposition and metabolic fate of 14C-granisetron, a novel 5-HT3 antagonist, was studied in rat, dog, and male human volunteers after intravenous and oral administration. 2. Complete absorption occurred from the gastrointestinal tract followin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f2af62345c076a81aa6cb2cf22fd6a8
https://doi.org/10.3109/00498259409038671
https://doi.org/10.3109/00498259409038671
Autor:
Wim J.G. Oyen, Markus Dietlein, Jan Tennvall, Michael Lassmann, S. E. Clarke, Markus Luster, Emilio Bombardieri, P. Lind
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging, 35, 1941-59
European Journal of Nuclear Medicine and Molecular Imaging, 35, 10, pp. 1941-59
European Journal of Nuclear Medicine and Molecular Imaging, 35, 10, pp. 1941-59
Contains fulltext : 70127.pdf (Publisher’s version ) (Closed access) INTRODUCTION: The purpose of the present guidelines on the radioiodine therapy (RAIT) of differentiated thyroid cancer (DTC) formulated by the European Association of Nuclear Medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff2980d3627423d2b611b77d2c785afb
http://hdl.handle.net/2066/70127
http://hdl.handle.net/2066/70127
Autor:
J. C. Bloomer, F. Ghanbari, S. E. Clarke, K Rowland-Yeo, Martin S. Lennard, Amin Rostami-Hodjegan, Geoffrey T. Tucker
Publikováno v:
Current drug metabolism. 7(3)
The published literature on mechanism based inhibition (MBI) of CYPs was evaluated with respect to experimental design, methodology and data analysis. Significant variation was apparent in the dilution factor, ratio of preincubation to incubation tim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e73923ccffb7f343d4dfc717d9003f82
https://pubmed.ncbi.nlm.nih.gov/16611025
https://pubmed.ncbi.nlm.nih.gov/16611025