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Quantitative Evaluation of Leukocyte Infiltration into the Spinal Cord in a Model of Experimental Autoimmune Encephalomyelitis: Statistical-Analytical Techniques for Use in Evaluating Drugs

Autor: K. A. Ready, S. M. Vroegop, L. A. Galinet, S. E. Buxser, D. L. Chapman, C. J. Dunn, T. J. Vidmar

Publikováno v: International Journal of Immunopathology and Pharmacology. 11:117-137

Experimental autoimmune encephalomyelitis (EAE) is considered a useful animal model for preclinical development of drugs to treat human multiple sclerosis. The relationship between clinical disease signs and leukocyte infiltration into the lower spin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c94a3fc0ca06e15dda74bfded2ac278
https://doi.org/10.1177/039463209801100302

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Analytical and numerical techniques for the evaluation of free radical damage in cultured cells using scanning laser microscopy

Autor: S. E. Buxser, T. J. Raub, D. E. Decker, G. A. Sawada

Publikováno v: Cytometry. 25:254-262

Scanning laser microscopy (SLM) was used to develop an assay to visualize the generation of intra-cellular reactive oxygen species (ROS) and to evaluate the effect of the lipophilic antioxidant U-87,663 on ROS formation. Cultured N18 neuroglioma cell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65f295321484cdcf73fd49de74c12765
https://doi.org/10.1002/(sici)1097-0320(19961101)25:3<254::aid-cyto6>3.0.co

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Immunological determinants of nerve growth factor involved in p140trk (Trk) receptor binding

Autor: Steven M. Vroegop, Jayasri Nanduri, Kenneth E. Neet, S. E. Buxser

Publikováno v: Journal of Neuroscience Research. 37:433-444

Monoclonal anti-NGF antibodies that specifically inhibit the biological activity of mouse beta-NGF were used to study the structural determinants involved in the interaction of NGF with its receptors gp75LNGFR and Trk. None of the three antibodies--N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecf657dee3fbdaf855ddabcca3d2ed6c
https://doi.org/10.1002/jnr.490370402

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Analytical and numerical techniques for evaluation of free radical damage in cultured cells using imaging cytometry and fluorescent indicators

Autor: S E, Buxser, G, Sawada, T J, Raub

Publikováno v: Methods in enzymology. 300

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::092e620a83044010a2e2d03166d1ddb1
https://pubmed.ncbi.nlm.nih.gov/9919529

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Competitive irreversible inhibition of dopamine uptake by 6-hydroxydopamine

Autor: D E, Decker, J S, Althaus, S E, Buxser, P F, VonVoigtlander, P L, Ruppel

Publikováno v: Research communications in chemical pathology and pharmacology. 79(2)

We examined the effects of 6-hydroxydopamine (6-OHDA) treatment on the human neuroblastoma cell line SK-N-SH-SY5Y (SY5Y) and the rat pheochromocytoma cell line, PC12. Structural and metabolic integrity was tested by measuring the ability of cells to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6f6c6e6174420e96efd0d687d200af65
https://pubmed.ncbi.nlm.nih.gov/8451541

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Cell surface molecules involved in early events in T-cell mitogenic stimulation by staphylococcal enterotoxins

Autor: S E Buxser, Steven M. Vroegop

Publikováno v: Infection and Immunity. 57:1816-1824

We tested the mitogenic response to staphylococcal enterotoxin (SE) type A and SE type B in spleen cells from five strains of mice and found consistent and significant differences among the strains. We chose to study the mitogenic responses of two of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e038f0431c40dc4170a9c679ef9721a
https://doi.org/10.1128/iai.57.6.1816-1824.1989

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Change in state of nerve growth factor receptor. Modulation of receptor affinity by wheat germ agglutinin

Autor: S E, Buxser, D J, Kelleher, L, Watson, P, Puma, G L, Johnson

Publikováno v: The Journal of biological chemistry. 258(6)

The binding of 125I-labeled nerve growth factor (NGF) to human melanoma cell (A875) membranes, detergent-soluble membrane extracts, and membrane extracts reconstituted into phospholipid vesicles was significantly increased when binding was carried ou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::59174c29b30f74c863ac06a7bd9b3de6
https://pubmed.ncbi.nlm.nih.gov/6300053

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Purification of the receptor for nerve growth factor from A875 melanoma cells by affinity chromatography

Autor: P, Puma, S E, Buxser, L, Watson, D J, Kelleher, G L, Johnson

Publikováno v: The Journal of biological chemistry. 258(5)

The receptor for nerve growth factor (NGF) has been purified to near homogeneity from octylglucoside extracts of A875 melanoma cell membranes by the use of repetitive affinity chromatography on NGF-Sepharose. Elution of purified receptor (NGF recepto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0c72dd48074e9b28bbea6cbb3fa7feea
https://pubmed.ncbi.nlm.nih.gov/6298234

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