Zobrazeno 1 - 10
of 18
pro vyhledávání: '"S E, Blackshaw"'
Amyotrophic lateral sclerosis (ALS) is a progressive degenerative disorder of motor neurones. Although the genetic basis of familial forms of ALS has been well explored, the molecular basis of sporadic ALS is less well understood. Recent evidence has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44a52bc7a5f6a366bc4563a762ce9b8d
https://doi.org/10.1002/bies.20836
https://doi.org/10.1002/bies.20836
Publikováno v:
Journal of Anatomy. 204:13-24
We have studied the molecular basis of nervous system repair in invertebrate (Hirudo medicinalis) nerve cells. Unlike in mammals, neurons in invertebrates survive injury and regrow processes to restore the connections that they held before the damage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::296750aa44f4c21a75e285f9e1987f6e
https://doi.org/10.1111/j.1469-7580.2004.00260.x
https://doi.org/10.1111/j.1469-7580.2004.00260.x
Autor:
S. E. Blackshaw, L. Breckenridge, Chris D. W. Wilkinson, Adam S. G. Curtis, Julian A. T. Dow, Patricia Connolly, Richard J. A. Wilson
Publikováno v:
Journal of Neuroscience Research. 42:266-276
We describe fabrication methods and the characterisation and use of extracellular microelectrode arrays for the detection of action potentials from neurons in culture. The 100 microns2 platinised gold microelectrodes in the 64 electrode array detect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67c883890cbeb6e598b2f78b7764ceb5
https://doi.org/10.1002/jnr.490420215
https://doi.org/10.1002/jnr.490420215
Autor:
L. Breckenridge, Richard J. A. Wilson, S. E. Blackshaw, Patricia Connolly, Chris D. W. Wilkinson, Adam S. G. Curtis, Julian A. T. Dow
Publikováno v:
Journal of Neuroscience Methods. 53:101-110
Planar extracellular electrode arrays provide a non-toxic, non-invasive method of making long-term, multisite recordings with moderately high spatial frequency (recording sites per unit area). This paper reports advances in the use of this approach t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ab958c701536cef9e9968ee6dbcdb0f
https://doi.org/10.1016/0165-0270(94)90150-3
https://doi.org/10.1016/0165-0270(94)90150-3
Autor:
A. M. Rowlerson, S. E. Blackshaw
Publikováno v:
Journal of Experimental Biology. 157:299-311
The fibre type composition of obliquely striated muscle of adult Hirudo medicinalis was investigated by enzyme histochemistry, by immunohistochemistry and by SDS-PAGE. The oxidative capacity of the fibres, assessed by succinate dehydrogenase activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::030fafcb567d2921aea349049e12422f
https://doi.org/10.1242/jeb.157.1.299
https://doi.org/10.1242/jeb.157.1.299
Publikováno v:
Cellular and molecular neurobiology. 25(2)
We have used the nervous system of the medicinal leech as a preparation to study the molecular basis of neural repair. The leech central nervous system, unlike mammalian CNS, can regenerate to restore function, and contains identified nerve cells of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52df92afb3156fe13171c97b329e7941
https://pubmed.ncbi.nlm.nih.gov/16047550
https://pubmed.ncbi.nlm.nih.gov/16047550
Publikováno v:
Journal of neurobiology. 54(4)
By the frequency-dependent release of serotonin, Retzius neurons in the leech modulate diverse behavioral responses of the animal. However, little is known about how their firing pattern is produced. Here we have analyzed the effects of mechanical st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3fb998f068166f722dcc6c19fb80dc7a
https://pubmed.ncbi.nlm.nih.gov/12555272
https://pubmed.ncbi.nlm.nih.gov/12555272
Publikováno v:
FEBS letters. 533(1-3)
A Hirudo medicinalis cDNA isolated from regenerating CNS tissue at 24 h post-axotomy was identified as a leech homologue of the mammalian cysteine-rich intestinal proteins (CRIPs) and named HmCRIP. HmCRIP is up-regulated within 6 h of axotomy, peakin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16b71c23dd207881c587f20674a1c06a
https://pubmed.ncbi.nlm.nih.gov/12505171
https://pubmed.ncbi.nlm.nih.gov/12505171
Autor:
A E Warner, S E Blackshaw
Publikováno v:
The Journal of Physiology. 255:209-230
1. Electrical connexions between mesoderm cells have been examined during the formation of somites in Xenopus laevis, Bombina orientalis and Ambystoma mexicanum. 2. In Xenopus the resting potentials of presumptive myotome cells (-65 + 2 mV, S.E. of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ab86e440ae415413f0e3666c7fccdff
https://doi.org/10.1113/jphysiol.1976.sp011276
https://doi.org/10.1113/jphysiol.1976.sp011276