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Two-stage exposure of Syrian-hamster-embryo cells to environmental carcinogens: superinduction of ornithine decarboxylase correlates with increase of morphological-transformation frequency

Autor: Nicole Pages, Laurent Gate, Véronique Cruciani, Haim Tapiero, Zoé Elias, Halima Bessi, G Nguyen-Ba, O. Poirot, C. Rast, Paule Vasseur, S. Dhalluin

Publikováno v: International Journal of Cancer. 75:744-749

As part of environmental toxicology, it is important to assess both the carcinogenic potential of xenobiotics and their mode of action on target cells. Since dysregulation of ornithine decarboxylase (ODC), a rate-limiting enzyme of polyamine biosynth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c6b3de27a24b4c19a54cd80259f2f10
https://doi.org/10.1002/(sici)1097-0215(19980302)75:5<744::aid-ijc13>3.0.co

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Protective effect of Crassostrea gigas extract on audiogenic seizures in magnesium deficient mice

Autor: Nicole Pages, H Tapiero, P Bac, S Dhalluin

Publikováno v: Biomedicine & Pharmacotherapy. 52:162-165

Summary Audiogenic seizures associated with loss of weight, prostration, piloerection, palpebral ptosis and motor deficiency were induced after sound stimulation of determined frequency and amplitude in magnesium-deficient DBA/2 mice. These symptoms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc8f56b4d3b06163cbb689a46e6035ed
https://doi.org/10.1016/s0753-3322(98)80205-9

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Akademický článek

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Apoptosis inhibition and ornithine decarboxylase superinduction as early epigenetic events in morphological transformation of Syrian hamster embryo cells exposed to 2-methoxyacetaldehyde, a metabolite of 2-methoxyethanol

Autor: G Nguyen-Ba, Nicole Pages, Haim Tapiero, S. Dhalluin, Paule Vasseur, O. Poirot, Z. Elias, Laurent Gate

Publikováno v: Toxicology letters. 105(2)

We have conducted a study to determine the carcinogenic potential of ethylene glycol monomethyl ether (EGME), a member of the glycol ether family, as compared to its reactive metabolite 2-methoxy-acetaldehyde (MALD). Since disruption of equilibrium b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24065666c30a08f59165080b77f11331
https://pubmed.ncbi.nlm.nih.gov/10221278

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The antioxidant effects of Crassostrea gigas extract (JCOE) in human volunteers

Autor: H, Tapiero, L, Gaté, S, Dhalluin, G, Nguyen Ba, V, Soupramanien, J, Kouyate, K D, Tew

Publikováno v: In vivo (Athens, Greece). 12(3)

Since several in vitro and animal studies of an extract from Crassostrea gigas (JCOE) have demonstrated its antioxidant properties and other interesting effects, a preliminary human trial was carried out. Seven healthy male volunteers aged 23-37 rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f4ddb0b9ae5983a60513206f5decce06
https://pubmed.ncbi.nlm.nih.gov/9706475

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Impact of dietary supplement of Crassostrea gigas extract (JCOE) on glutathione levels and glutathione S-transferase activity in rat tissues

Autor: L, Gaté, M, Schultz, E, Walsh, S, Dhalluin, G, Nguyen Ba, H, Tapiero, K D, Tew

Publikováno v: In vivo (Athens, Greece). 12(3)

Male Sprague Dawley rats received various amounts of extract of Crassostrea gigas by gavage every day for 2 weeks or one month. At these times, groups of animals were sacrificed and samples of major organs analyzed for levels of glutathione (GSH) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::668ab4aa3cd876b38789c1535356fcd7
https://pubmed.ncbi.nlm.nih.gov/9706474

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Dysregulation of ornithine decarboxylase activity, apoptosis and Bcl-2 oncoprotein in Syrian hamster embryo cells stage-exposed to di(2-ethylhexyl)phthalate and tetradecanoylphorbol acetate

Autor: G Nguyen-Ba, Laurent Gate, S. Dhalluin, Haim Tapiero, Paule Vasseur

Publikováno v: Carcinogenesis. 18(11)

3To whom correspondence should be addressed Perturbations of cell proliferation and death are considered as essential events in the process of carcinogenesis. Thus, two parameters, ornithine decarboxylase (ODC), an enzyme closely related to cell prol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf29ad80874889077b54cb241251c0e7
https://pubmed.ncbi.nlm.nih.gov/9395224

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