Výsledky vyhledávání - "S David, Kimball"

Supplementary Tables S1-S5 from Combinatorial Therapy of Zinc Metallochaperones with Mutant p53 Reactivation and Diminished Copper Binding

Autor: Darren R. Carpizo, S. David Kimball, Stewart N. Loh, David A. Boothman, John Gilleran, Alan J. Blayney, Bing Na, Tracy Withers, Yue Liu, Adam R. Blanden, Anthony F. Bencivenga, Xin Yu, Saif Zaman

Supplementary tables to show combination index values for combination treatments of indicated compounds. Supplementary Table 1. Combination Index values for initial combination treatment of ZMC1 with chemotherapy drugs; Supplementary Table 2. Combina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b552ac3dcc2e7479c6659a9b74c1df4
https://doi.org/10.1158/1535-7163.22505851.v1

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Supplementary Figures S1-S10 from Combinatorial Therapy of Zinc Metallochaperones with Mutant p53 Reactivation and Diminished Copper Binding

Suppl. Fig. S1 display ZMC1 structure. Suppl. Fig. S2 showed no synergy in combination treatment of ZMC1 and Adriamycin or IR. Suppl. Fig. S3 showed synergy in Detroit 562 cells by combination treatment of ZMC1 and Irinotecan in the presence of GSH.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::373924276ceb44d0f28384c120bb1228
https://doi.org/10.1158/1535-7163.22505854

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Supplementary methods from Combinatorial Therapy of Zinc Metallochaperones with Mutant p53 Reactivation and Diminished Copper Binding

Suppl. Methods included the methods used in the paper, Cell growth inhibition assay, Immunofluorescent staining, Synthesis of ZMC1, Synthesis of 2,2'-((2-Ethoxy-2-oxoethyl)azanediyl)diacetic acid (NTA-MEE) and NTA-DEE, Zn2+-Kd measurements by competi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7118ac2756632efdd25988ccd02b669d
https://doi.org/10.1158/1535-7163.22505848.v1

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Data from Zinc Metallochaperones Reactivate Mutant p53 Using an ON/OFF Switch Mechanism: A New Paradigm in Cancer Therapeutics

Autor: Darren R. Carpizo, Stewart N. Loh, S. David Kimball, Chang Chan, Joseph Bertino, Dirk Moore, Brian Buckley, John Gilleran, Hongxia Lin, Tracy Withers, Ashley T. Tsang, Ying Chen, Samuel Kogan, Xin Yu

Purpose: Zinc metallochaperones (ZMC) are a new class of anticancer drugs that reactivate zinc-deficient mutant p53 by raising and buffering intracellular zinc levels sufficiently to restore zinc binding. In vitro pharmacodynamics of ZMCs indicate th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e1caa6c09622d14f31a294747889e9b
https://doi.org/10.1158/1078-0432.c.6527462.v1

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Supplementary figures and tables from Zinc Metallochaperones Reactivate Mutant p53 Using an ON/OFF Switch Mechanism: A New Paradigm in Cancer Therapeutics

Supplementary figures and tables Supplementary Fig. S1. Quantitative RT-PCR (qPCR) validation of the expression of MT1A, MT2A, and ZnT1 in TOV112D cells after ZMC1 treatment. Supplementary Fig. S2. Quantitative RT-PCR (qPCR) validation of the knockou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4704e5d0c18adc372b3f30e43e462a39
https://doi.org/10.1158/1078-0432.22470215.v1

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Benzothiazolyl and Benzoxazolyl Hydrazones Function as Zinc Metallochaperones to Reactivate Mutant p53

Autor: John A. Gilleran, S. David Kimball, Jacques Roberge, Alan J. Blayney, Stewart N. Loh, Adam R. Blanden, David Augeri, Darren R. Carpizo, Anthony F. Bencivenga, Xin Yu, Bing Na

Publikováno v: J Med Chem

We identified a set of thiosemicarbazone (TSC) metal ion chelators that reactivate specific zinc-deficient p53 mutants using a mechanism called zinc metallochaperones (ZMCs) that restore zinc binding by shuttling zinc into cells. We defined biophysic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37960bf2b8c996bc4b1a6bffd407a5ac
https://doi.org/10.1021/acs.jmedchem.0c01360

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Combinatorial Therapy of Zinc Metallochaperones with Mutant p53 Reactivation and Diminished Copper Binding

Autor: Stewart N. Loh, Adam R. Blanden, Yue Liu, S. David Kimball, Bing Na, Tracy Withers, Anthony F. Bencivenga, Alan J. Blayney, Saif Zaman, Xin Yu, Darren R. Carpizo, David A. Boothman, John A. Gilleran

Publikováno v: Molecular Cancer Therapeutics. 18:1355-1365

Chemotherapy and radiation are more effective in wild-type (WT) p53 tumors due to p53 activation. This is one rationale for developing drugs that reactivate mutant p53 to synergize with chemotherapy and radiation. Zinc metallochaperones (ZMC) are a n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8918faaad9539fd65e5cb4d867c088d8
https://doi.org/10.1158/1535-7163.mct-18-1080

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Therapeutic targeting of BRCA1 and TP53 mutant breast cancer through mutant p53 reactivation

Autor: Ming Yao, Tracy Withers, Xin Yu, John A. Gilleran, S. David Kimball, Dirk F. Moore, Bing Xia, Shridar Ganesan, Chunxia Chen, Yong Lin, Darren R. Carpizo, Tzeh Keong Foo, Bing Na

Publikováno v: NPJ Breast Cancer
npj Breast Cancer, Vol 5, Iss 1, Pp 1-10 (2019)

Triple negative breast cancer (TNBC) is an aggressive subset for which effective therapeutic approaches are needed. A significant proportion of TNBC patients harbor either germline or somatic mutations in BRCA1, or epigenetic silencing of BRCA1, whic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6043e92f228aeb4d5643845cbe626a0
https://doi.org/10.1038/s41523-019-0110-1

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