Zobrazeno 1 - 6
of 6
pro vyhledávání: '"S D Lockyer"'
Autor:
Paul E. Murray, S D Lockyer, Ian J. Stratford, V McNally, Mohammed Jaffar, Sally Freeman, Kaye J. Williams
Publikováno v:
Bioorganic & Medicinal Chemistry. 10:525-530
A series of water soluble N(1)- and C(6)-substituted uracil pyridinium compounds were prepared as potential inhibitors of thymidine phosphorylase (TP). The C(6)-uracil substituted derivatives were the most active. 1-[(5-Chloro-2,4-dihydroxypyrimidin-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91822877466c9090499de21e36530e08
https://doi.org/10.1016/s0968-0896(01)00309-1
https://doi.org/10.1016/s0968-0896(01)00309-1
Autor:
Jonathan R. A. Roffey, Christopher J. Moody, Ian J. Stratford, Elizabeth Swann, S. Houlbrook, S D Lockyer
Publikováno v:
Anti-Cancer Drugs. 10:577-590
A number of thiazolyl indolequinones have been prepared and evaluated for their antitumor properties. The compounds were synthesized from the appropriate indole, building up the thiazole ring using the Hantzsch reaction. Cytotoxic activity was determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e7c0e0e97609f33f9ddb536c81c42ee
https://doi.org/10.1097/00001813-199907000-00010
https://doi.org/10.1097/00001813-199907000-00010
Autor:
Sally Freeman, V McNally, S D Lockyer, Paul E. Murray, Ian J. Stratford, Mohammed Jaffar, Kaye J. Williams
Publikováno v:
ChemInform. 33
A series of water soluble N(1)- and C(6)-substituted uracil pyridinium compounds were prepared as potential inhibitors of thymidine phosphorylase (TP). The C(6)-uracil substituted derivatives were the most active. 1-[(5-Chloro-2,4-dihydroxypyrimidin-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18a749f6bdce9d5e0fb03e17a7bbc530
https://doi.org/10.1002/chin.200220127
https://doi.org/10.1002/chin.200220127
Autor:
N Robertson, Ian J. Stratford, Peter Wardman, Michael R.L. Stratford, S D Lockyer, Steven Albert Everett, Elizabeth Swann, Kantilal B. Patel, Mohammed Jaffar, Christopher J. Moody, Madeleine F. Dennis, Matthew A. Naylor, John Nolan, Gerald E. Adams
Publikováno v:
Journal of medicinal chemistry. 41(15)
A series of indolequinones bearing a variety of leaving groups at the (indol-3-yl)methyl position was synthesized by functionalization of the corresponding 3-(hydroxymethyl)indolequinone, and the resulting compounds were evaluated in vitro as bioredu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a0d7ea24938021d15d77855a12b44b3
https://pubmed.ncbi.nlm.nih.gov/9667963
https://pubmed.ncbi.nlm.nih.gov/9667963
Autor:
M, Jaffar, M A, Naylor, N, Robertson, S D, Lockyer, R M, Phillips, S A, Everett, G E, Adams, I J, Stratford
Publikováno v:
Anti-cancer drug design. 13(2)
A series of regioisomeric analogues of 3-hydroxymethyl-5-aziridinyl-1-methyl-2-[1H-indole-4,7-dione]prop-2-en-1 -ol (EO9, NSC 382459) with the hydroxymethyl and hydroxypropenyl substituents situated at either the 2- or the 3-position of the indole ri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ea7d80b255378b529c539f46a758cd7c
https://pubmed.ncbi.nlm.nih.gov/9524554
https://pubmed.ncbi.nlm.nih.gov/9524554
Autor:
Mark P Saunders, Adam V. Patterson, Ian J. Stratford, Adrian L. Harris, E Chinje, S D Lockyer
Publikováno v:
Scopus-Elsevier
British Journal of Cancer
British Journal of Cancer
The bioreductive drug tirapazamine (TPZ, SR 4233, WIN 59075) is a lead compound in a series of potent cytotoxins that selectively kill hypoxic rodent and human solid tumour cells in vitro and in vivo. Phases II and III trials have demonstrated its ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a48e23a3fdcdc25cc02acaa950219e4
http://www.scopus.com/inward/record.url?eid=2-s2.0-0032759462&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-0032759462&partnerID=MN8TOARS
