Pet therapy program for antepartum high-risk pregnancies: a pilot study

Autor: D G Eastham, S N Barringer, Christian E. Lynch, Zachary N. Stowe, Song Ounpraseuth, Everett F. Magann, S D Lewis

Publikováno v: Journal of Perinatology. 34:816-818

This pilot study evaluated the potential benefits of pet therapy on symptoms of anxiety and depression in antepartum hospitalized women with high-risk pregnancies.Eighty-two women in a hospital-based setting completed the State-Trait Anxiety Inventor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8369cb96cfdf01f5a57dcf7e82d8a1e0
https://doi.org/10.1038/jp.2014.120

A layered approach to automated electrical safety analysis in automotive environments

Autor: Chris Price, Neal Snooke, S. D. Lewis

Publikováno v: Price, C J, Snooke, N A & Lewis, S D 2006, ' A layered approach to automated electrical safety analysis in automotive environments ', Computers in Industry, vol. 57, no. 5, pp. 451-461 . https://doi.org/10.1016/j.compind.2006.02.001

Software support for the automotive electrical design process is vital, as many of the safety analysis tasks needing to be carried out, while complex, are repetitive and time consuming. Such support is required throughout the design process, but the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdede538a737e625e0eeb57b6c5cc64c
https://doi.org/10.1016/j.compind.2006.02.001

Development of an oxazolopyridine series of dual thrombin/factor Xa inhibitors via structure-guided lead optimization

Autor: James Z. Deng, S. D. Lewis, P.M. Rabbat, Craig A. Coburn, Terry A. Lyle, J. P. Vacca, Bobby J. Lucas, Daniel R. McMasters, Julie A. Krueger, B. Strulovici, Youwei Yan, Peter D. Williams, Lawrence Kuo, Christopher S. Burgey

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 15:4411-4416

Thrombin-inhibitor X-ray crystal structures, in combination with the installation of binding elements optimized within the pyrazinone series of thrombin inhibitors, were utilized to transform a weak triazolopyrimidine lead into a series of potent oxa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1043fcace9743b215fcb917a262ed643
https://doi.org/10.1016/j.bmcl.2005.07.022

Assessment of Thrombin Inhibitor Efficacy in a Novel Rabbit Model of Simultaneous Arterial and Venous Thrombosis

Autor: S. D. Lewis, Marsh Lyle E, Motzel Sl, Stephen J. Gardell, Lehman Ed, J.J. Lynch

Publikováno v: Thrombosis and Haemostasis. 79:656-662

SummaryThe importance of thrombin in arterial and venous thrombosis renders thrombin inhibition an important therapeutic target. Identification of novel inhibitors requires an appropriate animal model. We modified a previously reported rat arterial t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b74afe60b5669279a90a2e7d0e2fc24a
https://doi.org/10.1055/s-0037-1614962

Discovery of a Novel, Selective, and Orally Bioavailable Class of Thrombin Inhibitors Incorporating Aminopyridyl Moieties at the P1 Position

Autor: Shi-Shan Mao, E P Baskin, Julie A. Krueger, Mark G. Bock, Dong-Mei Feng, A. M. Mulichak, Stephen J. Gardell, Roger M. Freidinger, Lucas R, Ramjit Hg, Jules A. Shafer, S. D. Lewis, R Woltmann, K B Dancheck, Timothy R. Hare, J.J. Lynch, Adel M. Naylor-Olsen, I.-W. Chen, Zhongguo Chen, Joe P. Vacca

Publikováno v: Journal of Medicinal Chemistry. 40:3726-3733

A novel class of thrombin inhibitors incorporating aminopyridyl moieties at the P1 position has been discovered. Four of these thrombin inhibitors (13b,c,e and 14d) showed nanomolar potency (Ki 0.8-12 nM), 300-1500-fold selectivity for thrombin compa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a9c3eb4d8f15436d50d759edace5a6
https://doi.org/10.1021/jm970493r