Zobrazeno 1 - 10
of 28
pro vyhledávání: '"S D Gillies"'
Publikováno v:
Protein Engineering Design and Selection. 11:495-500
We have developed a general expression system that enhances the production and secretion of proteins in mammalian cells. The protein of interest is expressed as a fusion to a signal peptide and the Fc fragment of immunoglobulin as the N-terminal fusi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d6f783f93871863ed32a3d99cae8cb
https://doi.org/10.1093/protein/11.6.495
https://doi.org/10.1093/protein/11.6.495
Publikováno v:
The Journal of Immunology. 157:1582-1588
mAb against GD3 ganglioside demonstrate homophilic binding in which soluble anti-GD3 mAb bind, through the GD3 binding site, to a VH idiotope (designated IdHOM) on solid phase anti-GD3 mAb. In this way, homophilic binding provides a mechanism for amp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef07de9e5a4e2d4c8f5a1ecff0f77383
https://doi.org/10.4049/jimmunol.157.4.1582
https://doi.org/10.4049/jimmunol.157.4.1582
Publikováno v:
Journal of Biological Chemistry. 268:364-370
Human serum (MBP) and human recombinant (rMBP) mannose-binding protein bind to mannose-rich, serum-resistant Salmonella montevideo (SH5770), enhance C3 deposition, and render the organisms serum-sensitive. We investigated structural features of MBP n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ccb4519b314107f31ce7ea7b547806d
https://doi.org/10.1016/s0021-9258(18)54159-4
https://doi.org/10.1016/s0021-9258(18)54159-4
Autor:
Kedarnath N. Sastry, J. E. Schweinle, V. J. Silverman, Michael Super, R. A. B. Ezekowitz, S. Foley, S. D. Gillies
Publikováno v:
Nature Genetics. 2:50-55
Human mannose binding protein (MBP) is a C-type serum lectin involved in first-line host defense against a variety of bacterial, fungal and viral pathogens. Recently an association was found between low levels of serum MBP and an increased frequency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf2f9ea6d5669e99f658b445fcab497
https://doi.org/10.1038/ng0992-50
https://doi.org/10.1038/ng0992-50
Publikováno v:
The Journal of Immunology. 146:1067-1071
A genetically engineered conjugate between an anti-CD3 antibody and epidermal growth factor (EGF) was tested for its ability to mediate the lysis of receptor-bearing cells by human CTL. This construct was made by fusing an EGF coding sequence to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5944dd33111e48b6c02a0cd5b8b1827a
https://doi.org/10.4049/jimmunol.146.3.1067
https://doi.org/10.4049/jimmunol.146.3.1067
Publikováno v:
The Journal of Immunology. 144:1382-1386
A mouse/human chimeric antibody (ch14.18) was developed that reacts with the disialoganglioside GD2 on the surface of tumor cells of neuroectodermal origin. ch14.18 has the constant regions of a human IgG1 antibody and was expressed in a murine hybri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3849d5bd1aaad9dc81c711571bce93b5
https://doi.org/10.4049/jimmunol.144.4.1382
https://doi.org/10.4049/jimmunol.144.4.1382
Autor:
J M, Ruehlmann, R, Xiang, A G, Niethammer, Y, Ba, U, Pertl, C S, Dolman, S D, Gillies, R A, Reisfeld
Publikováno v:
Cancer research. 61(23)
The induction of a CTL response capable of eradicating disseminated tumor metastases and the establishment of a persistent tumor-protective immunity remain major goals of cancer immunotherapy. Here, we demonstrate for the first time that the combinat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c7ac4a9653af1b119d081e5844fb4155
https://pubmed.ncbi.nlm.nih.gov/11731434
https://pubmed.ncbi.nlm.nih.gov/11731434
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 7(9)
Immune-based therapies, such as the immunocytokine huKS-IL2, exert potent antitumor responses in some animal models by targeting cytokine activity to the tumor microenvironment. We found that certain chemotherapy agents in the appropriate dose and sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::37c5cfb728e1fd7c3500da56fd0d6071
https://pubmed.ncbi.nlm.nih.gov/11555604
https://pubmed.ncbi.nlm.nih.gov/11555604
Autor:
M, Imboden, K R, Murphy, A L, Rakhmilevich, Z C, Neal, R, Xiang, R A, Reisfeld, S D, Gillies, P M, Sondel
Publikováno v:
Cancer research. 61(4)
The huKS1/4-IL2 fusion protein, directed against the human epithelial cell adhesion molecule (huEpCAM) has been shown to induce a strong CD8+ T-cell-dependent, natural killer (NK) cell-independent, antitumor response in mice bearing the huEp-CAM-tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4809b931f546eac5038a01a26d614b9c
https://pubmed.ncbi.nlm.nih.gov/11245457
https://pubmed.ncbi.nlm.nih.gov/11245457
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(7)
Eradication of established colon carcinoma metastases is a major goal for adjuvant immunotherapy of this disease. This was accomplished in a murine model by targeting IL-2 to the tumor microenvironment with a recombinant Ab-IL-2 fusion protein (huKS1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::58c3ad20a119a2b3ce8f9dd33bd5def2
https://pubmed.ncbi.nlm.nih.gov/10490962
https://pubmed.ncbi.nlm.nih.gov/10490962