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Mechanism of hepatocellular uptake of albumin-bound bilirubin

Autor: S D, Zucker, W, Goessling

Publikováno v: Biochimica et biophysica acta. 1463(2)

We previously demonstrated that unconjugated bilirubin spontaneously diffuses through phospholipid bilayers at a rate which exceeds albumin dissociation, suggesting that solvation from albumin represents the rate-limiting step in hepatic bilirubin cl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::70876a2e18911a7cd58eee361f5d2384
https://pubmed.ncbi.nlm.nih.gov/10675499

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Kinetics of bilirubin transfer between serum albumin and membrane vesicles. Insight into the mechanism of organic anion delivery to the hepatocyte plasma membrane

Autor: S D, Zucker, W, Goessling, J L, Gollan

Publikováno v: The Journal of biological chemistry. 270(3)

Unconjugated bilirubin is transported in the plasma bound primarily to serum albumin, from which it is taken up and metabolized by the liver. To better characterize the mechanism of bilirubin delivery to the hepatocyte, stopped-flow techniques were u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::298c8635f3471e1886c1c7057675b5c2
https://pubmed.ncbi.nlm.nih.gov/7836362

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