Výsledky vyhledávání - "S D, Studenberg"

THE PHARMACOKINETICS OF 1954U89, 1, 3-DIAMINO-7-(1-ETHYLPROPYL)-8-METHYL-7H-PYRROLO-(3, 2-f )QUINAZOLINE, IN DOGS AND RATS AFTER INTRAVENOUS AND ORAL ADMINISTRATION

Autor: Joseph L. Woolley, W. A. Wargin, S. D. Studenberg, D. V. Deangelis

Publikováno v: Biopharmaceutics & Drug Disposition. 18:433-442

1954U89, 1, 3-diamino-7-(1-ethylpropyl)-8-methyl-7H-pyrrolo-(3, 2-f )quinazoline, is a potent, lipid-soluble inhibitor of dihydrofolate reductase. The pharmacokinetics and bioavailability of 1954U89 were examined in male beagle dogs and male CD rats.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3710422efa93a0fe6a8077a5e2e4fb1f
https://doi.org/10.1002/(sici)1099-081x(199707)18:5<433::aid-bdd32>3.0.co

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High Performance Liquid Chromatographic Assay with Fluorescence Detection for the Analysis of 1954U89, 1,3-Diamino-7-(1-ethylpropyl)-8-methyl-7H-pyrrolo-(3,2-f)-quinazoline, in Plasma

Autor: D. V. Deangelis, S. D. Studenberg, Joseph L. Woolley

Publikováno v: Journal of Liquid Chromatography & Related Technologies. 19:823-836

1954U89, 1,3-diamino -7 - (1-ethylpropyl) -8- methyl-7H-pyrrolo(3,2-f)-quinazoline, is a potent, lipid-soluble inhibitor of dihydrofolate reductase that is under preclinical evaluation as an anticancer agent. A rapid and selective high performance li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb13c7296f1e9c62ed8dc11f2515c08e
https://doi.org/10.1080/10826079608005540

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Role of P-glycoprotein on the CNS disposition of amprenavir (141W94), an HIV protease inhibitor

Autor: J W, Polli, J L, Jarrett, S D, Studenberg, J E, Humphreys, S W, Dennis, K R, Brouwer, J L, Woolley

Publikováno v: Pharmaceutical research. 16(8)

To determine the role of P-glycoprotein (Pgp) on the CNS penetration of the HIV protease inhibitor (PI) amprenavir (141W94) and to test the hypothesis that co-administration of a second HIV PI (ritonavir) could enhance amprenavir's brain penetration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d2e3924f77f772bd3722531d81450063
https://pubmed.ncbi.nlm.nih.gov/10468021

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The pharmacokinetics of 1954U89, 1,3-diamino-7-(1-ethylpropyl)-8-methyl-7H-pyrrolo-(3,2-f)quinazoline, in dogs and rats after intravenous and oral administration

Autor: S D, Studenberg, J L, Woolley, D V, Deangelis, W A, Wargin

Publikováno v: Biopharmaceuticsdrug disposition. 18(5)

1954U89, 1,3-diamino-7-(1-ethylpropyl)-8-methyl-7H-pyrrolo-(3, 2-f)quinazoline, is a potent, lipid-soluble inhibitor of dihydrofolate reductase. The pharmacokinetics and bioavailability of 1954U89 were examined in male beagle dogs and male CD rats. D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e79a7fcaad09de4a7cba5203782f8dfb
https://pubmed.ncbi.nlm.nih.gov/9210981

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Hepatic disposition of acetaminophen and metabolites. Pharmacokinetic modeling, protein binding and subcellular distribution

Autor: S D, Studenberg, K L, Brouwer

Publikováno v: Biochemical pharmacology. 46(4)

Successful pharmacokinetic modeling often requires the ability of a simple model to describe a complex series of physiological processes. However, a simple model may be inappropriate. Physiologically-relevant modeling may offer a more appropriate des

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::933e61fe9f79c9a954029c8348ae9549
https://pubmed.ncbi.nlm.nih.gov/8363647

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Impaired biliary excretion of acetaminophen glucuronide in the isolated perfused rat liver after acute phenobarbital treatment and in vivo phenobarbital pretreatment

Autor: S D, Studenberg, K L, Brouwer

Publikováno v: The Journal of pharmacology and experimental therapeutics. 261(3)

The influence of phenobarbital (PB) on the hepatobiliary disposition of acetaminophen (APAP), acetaminophen glucuronide (AG) and acetaminophen sulfate (AS) was examined in the recirculating isolated perfused rat liver (IPL). PB was administered as a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::69145480d35a41f7304af8bdfd2f4e77
https://pubmed.ncbi.nlm.nih.gov/1602370

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Phenacetin and acetaminophen metabolism in the isolated perfused rat liver. Precursor concentration influences the selection of kinetic parameters to assess hypoxic impairment

Autor: S D, Studenberg, K L, Brouwer

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 19(2)

Subnormal oxygen concentrations affect a host of cellular functions and can exist under normal or pathological conditions. The present study examined the effects of hypoxia on phenacetin O-deethylation by the mixed-function oxidase system and the sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9e4d62520f2ac7a7d0ec883e2f8db0e8
https://pubmed.ncbi.nlm.nih.gov/1676648

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Digoxin-like immunoreactivity eliminated from serum by centrifugal ultrafiltration before fluorescence polarization immunoassay of digoxin

Autor: Robert H. Christenson, Frank A. Sedor, S Beck-Davis, S D Studenberg

Publikováno v: Clinical Chemistry. 33:606-608

Digoxin determined in the Abbott "TDx" by fluorescence polarization immunoassay by the manufacturer's recommended method involving precipitation of protein with 5-sulfosalicylic acid (SSA) is subject to interference from endogenous compounds having d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::00b7b3b51b944246a6d9debec50d3bed
https://doi.org/10.1093/clinchem/33.4.606

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Digoxin-like immunoreactivity eliminated from serum by centrifugal ultrafiltration before fluorescence polarization immunoassay of digoxin

Autor: R H, Christenson, S D, Studenberg, S, Beck-Davis, F A, Sedor

Publikováno v: Clinical chemistry. 33(4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9e998fbb82ba83ed47907998573b1d64
https://pubmed.ncbi.nlm.nih.gov/3549061

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