Zobrazeno 1 - 10
of 225
pro vyhledávání: '"S D, Putney"'
Autor:
P. Lynch, S. D. Putney, E. Park, J. P. McGrath, A. J. Schutz, J. George, R. M. Starzyk, T. Lee
Publikováno v:
Journal of Drug Targeting. 6:53-64
To explore the ability to use genetic fusions of transferrin as a carrier for brain targeting and delivery, a series of fusion proteins containing both human nerve growth factor (NGF) and human transferrin was produced in mammalian cells. A protein i
Autor:
S. D. Putney, X Cao, P Lynch, J. P. McGrath, Ted Ebendal, S L Morrison, A. J. Schutz, M J Coloma
Publikováno v:
Journal of Neuroscience Research. 47:123-133
The cDNAs encoding the variable regions of the heavy and light chains of a murine antibody specific for the human TfR were cloned and a human chimera (gamma1, kappa) was produced. A gene fusion was created by joining the 3' end of the coding region o
Autor:
R.A Hamilton, Neal F. Gordon, A Schutz, S. D. Putney, P.D Lynch, A.J Hunt, X Cao, Tom Londo, T McCormack, P Dimond, M Percoskie, J.P McGrath
Publikováno v:
Journal of Chromatography A. 708:61-70
A purification process and an on-line process monitoring procedure for a human nerve growth factor (NGF) fusion antibody (NAK) was developed. The NAK protein was produced with a recombinant technique by an adherent Chinese hamster ovary cell line in
Autor:
Daniel R. Lucey, C D Pendleton, Gene M. Shearer, Jeffrey D. Ahlers, Jay A. Berzofsky, S D Putney, Mario Clerici
Publikováno v:
Journal of Clinical Investigation. 88:876-884
To make synthetic peptide vaccines effective in a broad population of outbred humans, one would have to incorporate enough antigenic determinants to elicit recognition by T cells of most HLA types. We have previously defined multideterminant regions
Autor:
D R Lee, Peter L. Nara, S Matsushita, S D Putney, Joseph P. Davide, William A. Schleif, J Kessler, Emilio A. Emini, S Conley, John A. Lewis
Publikováno v:
Journal of Virology. 64:3674-3678
This study was undertaken to establish whether antibody directed against the human immunodeficiency virus type 1 (HIV-1) principal gp120 type-specific neutralization determinant can abolish the infectivity of HIV-1 in chimpanzees. Challenge inocula o
Autor:
S. D. Putney, Y. Eda, Krishna K. Murthy, Jorg W. Eichberg, C. M. Jett, William A. Schleif, Emilio A. Emini, J. H. Nunberg, K E Cobb, S. Tokiyoshi, S. Matsushrta, A. J. Conley
Publikováno v:
Nature. 355:728-730
THE acquired immunodeficiency syndrome (AIDS) is the late-stage clinical manifestation of long-term persistent infection with the human immunodeficiency virus type 1 (HIV-1). Immune responses directed against the virus and against virus-infected cell
Autor:
P, Herbert, K, Murphy, O, Johnson, N, Dong, W, Jaworowicz, M A, Tracy, J L, Cleland, S D, Putney
Publikováno v:
Pharmaceutical research. 15(2)
Autor:
O L, Johnson, W, Jaworowicz, J L, Cleland, L, Bailey, M, Charnis, E, Duenas, C, Wu, D, Shepard, S, Magil, T, Last, A J, Jones, S D, Putney
Publikováno v:
Pharmaceutical research. 14(6)
To produce and evaluate sustained-acting formulations of recombinant human growth hormone (rhGH) made by a novel microencapsulation process.The protein was stabilized by forming an insoluble complex with zinc and encapsulated into microspheres of pol
Autor:
H J, Lee, G, Riley, O, Johnson, J L, Cleland, N, Kim, M, Charnis, L, Bailey, E, Duenas, A, Shahzamani, M, Marian, A J, Jones, S D, Putney
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 281(3)
Long-acting formulations of recombinant human growth hormone (rhGH) were prepared by stabilizing and encapsulating the protein into three different injectable, biodegradable microsphere formulations composed of polymers of lactic and glycolic acid. T
Autor:
J P, McGrath, X, Cao, A, Schutz, P, Lynch, T, Ebendal, M J, Coloma, S L, Morrison, S D, Putney
Publikováno v:
Journal of neuroscience research. 47(2)
The cDNAs encoding the variable regions of the heavy and light chains of a murine antibody specific for the human TfR were cloned and a human chimera (gamma1, kappa) was produced. A gene fusion was created by joining the 3' end of the coding region o