Výsledky vyhledávání

A pharmacodynamic study of sorafenib in patients with relapsed and refractory acute leukemias

Autor: Ming Zhao, Michael A. McDevitt, Eunpi Cho, Michelle A. Rudek, John J. Wright, Mark J. Levis, Keith W. Pratz, Adam Stine, Michael A. Carducci, S D Gore, Sharyn D. Baker, Judith E. Karp, B. D. Smith

Publikováno v: Leukemia

We report the results of a phase I dose escalation trial of the multikinase inhibitor sorafenib in relapsed and refractory acute leukemia patients using an intermittent dosing regimen. Fifteen patients with advanced leukemia (12 with acute myeloid le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07ba3f6082190462104828c56d6e971a
https://doi.org/10.1038/leu.2010.132

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A Phase I Dose-Finding Study of 5-Azacytidine in Combination with Sodium Phenylbutyrate in Patients with Refractory Solid Tumors

Autor: Sharyn D. Baker, James A. Zwiebel, Richard F. Ambinder, Anchalee Jiemjit, Ross C. Donehower, Ming Zhao, Michael A. Carducci, Michelle A. Rudek, Jianqing Lin, S D Gore, Jill Gilbert, James G. Herman

Publikováno v: Clinical Cancer Research. 15:6241-6249

Purpose: This was a phase I trial to determine the minimal effective dose and optimal dose schedule for 5-azacytidine (5-AC) in combination with sodium phenylbutyrate in patients with refractory solid tumors. The pharmacokinetics, pharmacodynamics, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11587491bbf45641facd7b2bce94fe04
https://doi.org/10.1158/1078-0432.ccr-09-0567

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Quantification of 5-azacytidine in plasma by electrospray tandem mass spectrometry coupled with high-performance liquid chromatography

Autor: Sharyn D. Baker, Ming Zhao, Ping He, Carol Hartke, S D Gore, Michelle A. Rudek, Michael A. Carducci

Publikováno v: Journal of Chromatography B. 813:81-88

5-Azacytidine (5AC), a nucleoside analogue and hypomethylating agent, has anticancer properties and has been utilized in the treatment of various malignancies. 5AC is unstable and rapidly hydrolyzed to several by-products, including 5-azacytosine and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89de6eed5e6b486eeadca926fe80e4dc
https://doi.org/10.1016/j.jchromb.2004.09.012

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Long-term follow-up of intensive ara-C-based chemotherapy followed by bone marrow transplantation for adult acute lymphoblastic leukemia: impact of induction Ara-C dose and post-remission therapy

Autor: Philip J. Burke, Judith E. Karp, Scott D. Rowley, S D Gore, Hayden G. Braine, Scott H. Kaufmann, S Piantadosi, Richard J. Jones, E.M. Sotomayor, Carole B. Miller

Publikováno v: Leukemia Research. 26:461-471

We report single institution outcome of brief, intensive ara-C-based chemotherapy using bone marrow transplantation as primary intensification for untreated adult patients with acute lymphoblastic leukemia (ALL). Overall disease-free and overall surv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2b1e9da64b5b6281bde39b07b6373a
https://doi.org/10.1016/s0145-2126(01)00175-8

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Normal human bone marrow precursors that express terminal deoxynucleotidyl transferase include T-cell precursors and possible lymphoid stem cells

Autor: S D, Gore, M B, Kastan, C I, Civin

Publikováno v: Blood. 77:1681-1690

To compare the differentiation of early B- and T-lymphoid precursors, we have used immune adherence combined with analytical flow cytometric techniques to enrich and characterize subsets of the small population of bone marrow mononuclear cells that e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03d58f1aa9a2b49b5c709e98ef2f21f9
https://doi.org/10.1182/blood.v77.8.1681.bloodjournal7781681

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p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage

Autor: Hetty E. Carraway, Tamer E. Fandy, S D Gore, Anchalee Jiemjit, J G Herman, Stephen B. Baylin, Kayleen Bailey

Publikováno v: Oncogene. 27(25)

Decitabine (DAC) and 5-azacitidine have recently been approved for the treatment of myelodysplastic syndrome. The pharmacodynamic effects of DAC and 5-azacitidine outside their known activity as inhibitors of DNA methyltransferases (DNMTs) require fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c03963f151c1104f6676b486849074
https://pubmed.ncbi.nlm.nih.gov/18223691

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The clinical application of targeting cancer through histone acetylation and hypomethylation

Autor: S D Gore, Michael A. Carducci, James G. Herman, Jill Gilbert

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 10(14)

Methods of gene inactivation include genetic events such as mutations or deletions. Epigenetic changes, heritable traits that are mediated by changes in DNA other than nucleotide sequences, play an important role in gene expression. Two epigenetic ev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e101c9f704bd59772a557772ac195e6e
https://pubmed.ncbi.nlm.nih.gov/15269129

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