Výsledky vyhledávání

Akademický článek

Amphibian mast cells serve as barriers to chytrid fungus infections

Autor: Kelsey A Hauser, Christina N Garvey, Ryley S Crow, Muhammad RH Hossainey, Dustin T Howard, Netra Ranganathan, Lindsey K Gentry, Amulya Yaparla, Namarta Kalia, Mira Zelle, Elizabeth J Jones, Anju N Duttargi, Louise A Rollins-Smith, Carly R Muletz-Wolz, Leon Grayfer

Publikováno v: eLife, Vol 12 (2024)

Global amphibian declines are compounded by deadly disease outbreaks caused by the chytrid fungus, Batrachochytrium dendrobatidis (Bd). Much has been learned about the roles of amphibian skin-produced antimicrobial components and microbiomes in contr

Externí odkaz: https://doaj.org/article/a6f4c7e33df0419d8c8ae8351a05cfe1

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Akademický článek

Spotting disease disrupts the microbiome of infected purple sea urchins, Strongylocentrotus purpuratus

Autor: Chloe G. Shaw, Christina Pavloudi, Ryley S. Crow, Jimmy H. Saw, L. Courtney Smith

Publikováno v: BMC Microbiology, Vol 24, Iss 1, Pp 1-21 (2024)

Abstract Background Spotting disease infects a variety of sea urchin species across many different marine locations. The disease is characterized by discrete lesions on the body surface composed of discolored necrotic tissue that cause the loss of al

Externí odkaz: https://doaj.org/article/21168d34bb4a438fb722e9c6c2a74365

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Akademický článek

Recombinant SpTransformer proteins are functionally diverse for binding and phagocytosis by three subtypes of sea urchin phagocytes

Autor: Ryley S. Crow, Chloe G. Shaw, Leon Grayfer, L Courtney Smith

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionThe California purple sea urchin, Strongylocentrotus purpuratus, relies solely on an innate immune system to combat the many pathogens in the marine environment. One aspect of their molecular defenses is the SpTransformer (SpTrf) gene fam

Externí odkaz: https://doaj.org/article/19335fcf889745af8d42d00a42c601e2

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Akademický článek

The DNA Sensor IFIX Drives Proteome Alterations To Mobilize Nuclear and Cytoplasmic Antiviral Responses, with Its Acetylation Acting as a Localization Toggle

Autor: Timothy R. Howard, Marni S. Crow, Todd M. Greco, Krystal K. Lum, Tuo Li, Ileana M. Cristea

Publikováno v: mSystems, Vol 6, Iss 3 (2021)

Mammalian cells must be able to detect and respond to invading pathogens to prevent the spread of infection. DNA sensors, such as IFIX, are proteins that bind to pathogen-derived double-stranded DNA and induce antiviral cytokine expression.

Externí odkaz: https://doaj.org/article/298b9a6dd03e46b69912ca7d1a027da4

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