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of 484
pro vyhledávání: '"S Conn"'
Autor:
Dat P. Ha, Woo-Jin Shin, Ze Liu, Michael E. Doche, Roy Lau, Nektaria Maria Leli, Crystal S. Conn, Mariangela Russo, Annalisa Lorenzato, Constantinos Koumenis, Min Yu, Shannon M. Mumenthaler, Amy S. Lee
Publikováno v:
Cell & Bioscience, Vol 14, Iss 1, Pp 1-25 (2024)
Abstract Background Despite recent therapeutic advances, combating cancer resistance remains a formidable challenge. The 78-kilodalton glucose-regulated protein (GRP78), a key stress-inducible endoplasmic reticulum (ER) chaperone, plays a crucial rol
Externí odkaz:
https://doaj.org/article/41b097963d3a4f95bc528fc71d41ad9c
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
During their quest for growth, adaptation, and survival, cancer cells create a favorable environment through the manipulation of normal cellular mechanisms. They increase anabolic processes, including protein synthesis, to facilitate uncontrolled pro
Externí odkaz:
https://doaj.org/article/8d8348edcf2e4842aebee96068874d57
Autor:
Michael J. Evans, Jason S. Lewis, Davide Ruggero, Crystal S. Conn, Loc T. Huynh, Matthew F.L. Parker, John T. Cunningham, Charles Truillet
Supplemental Methods, Supplementary Figure 1. A. Real time PCR data showing the suppression of PTEN mRNA levels by an anti PTEN shRNA in GBM and PCa cell lines. The suppression of PTEN mRNA was statistically significant (P < 0.05). B. Immunoblot data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7922640158fe2775886b7bd81b446ec6
https://doi.org/10.1158/1078-0432.22462844.v1
https://doi.org/10.1158/1078-0432.22462844.v1
Autor:
Michael J. Evans, Jason S. Lewis, Davide Ruggero, Crystal S. Conn, Loc T. Huynh, Matthew F.L. Parker, John T. Cunningham, Charles Truillet
Purpose: mTOR regulates many normal physiological processes and when hyperactive can drive numerous cancers and human diseases. However, it is very challenging to detect and quantify mTOR signaling noninvasively in clinically relevant animal models o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d72cf13b11f581319999c437486fd2e
https://doi.org/10.1158/1078-0432.c.6525230
https://doi.org/10.1158/1078-0432.c.6525230
Akademický článek
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Autor:
Yasuo Oguri, Shingo Kajimura, Ralph J. DeBerardinis, Supna Nair, Kenji Ikeda, Ryan M. Gill, Juan A. Oses-Prieto, Alma L. Burlingame, Davide Ruggero, Harrison J. Tom, Haojun Yang, Hieu Sy Vu, Crystal S. Conn
Publikováno v:
Nature Metabolism. 3:244-257
Obesity is a global epidemic leading to increased mortality and susceptibility to comorbidities, with few viable therapeutic interventions. A hallmark of disease progression is the ectopic deposition of lipids in the form of lipid droplets in vital o
Autor:
Duo Zhang, Albert M. Li, Guanghui Hu, Menggui Huang, Fan Yang, Lin Zhang, Kathryn E. Wellen, Xiaowei Xu, Crystal S. Conn, Wei Zou, Mark Kahn, Seth D. Rhoades, Aalim M. Weljie, Serge Y. Fuchs, Nduka Amankulor, Daniel Yoshor, Jiangbin Ye, Constantinos Koumenis, Yanqing Gong, Yi Fan
Publikováno v:
Cell Metabolism. 35:517-534.e8
Autor:
David A. Fruman, Lee-or Herzog, Davide Ruggero, Roberta Buono, Sharmila Mallya, Crystal S. Conn, Honyin Chiu, Leandra V. Jackson
Publikováno v:
iScience, Vol 24, Iss 7, Pp 102748-(2021)
iScience, vol 24, iss 7
iScience
iScience, vol 24, iss 7
iScience
Summary The cap-binding protein eukaryotic initiation factor 4E (eIF4E) promotes translation of mRNAs associated with proliferation and survival and is an attractive target for cancer therapeutics. Here, we used Eif4e germline and conditional knockou