Zobrazeno 1 - 10
of 39
pro vyhledávání: '"S Casey, Laizure"'
Autor:
Bing Yang, Robert B Parker, Bernd Meibohm, Zaid H Temrikar, Ashish Srivastava, S Casey Laizure
Publikováno v:
PLoS ONE, Vol 17, Iss 11, p e0278111 (2022)
Dimethyl fumarate (DMF) is a first-line prodrug for the treatment of relapsing-remitting multiple sclerosis (RRMS) that is completely metabolized to monomethyl fumarate (MMF), the active metabolite, before reaching the systemic circulation. Its metab
Externí odkaz:
https://doaj.org/article/0929d5d3f7e143f6b238c74808f1332a
Publikováno v:
Drug Metabolism and Pharmacokinetics. 47:100479
Dabigatran etexilate (DABE), an oral anticoagulant prodrug, is nearly completely metabolized to the dabigatran (DAB) active metabolite by carboxylesterase-1 (CES1) and carboxylesterase-2 (CES2). The high interpatient variation in DAB plasma concentra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca9831b7ba3591d6af5b786a6516fd0
https://doi.org/10.1016/j.dmpk.2022.100479
https://doi.org/10.1016/j.dmpk.2022.100479
Publikováno v:
Xenobiotica. 50:245-251
Clopidogrel is widely prescribed in patients with cardiovascular disease. Most research has focused on the role of hepatic CYP450 metabolism as the primary source of response variability despite 85-90% of clopidogrel being hydrolyzed by human carboxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bb525f721d277155cb016ce9843bf37
https://doi.org/10.1080/00498254.2019.1612535
https://doi.org/10.1080/00498254.2019.1612535
Publikováno v:
Expert Opinion on Drug Metabolism & Toxicology. 14:131-142
Mammalian carboxylesterase enzymes are a highly conserved metabolic pathway involved in the metabolism of endogenous and exogenous compounds including many widely prescribed therapeutic agents. Recent advances in our understanding of genetic polymorp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edd97fafa1e15a8428bf27d6eb57cde2
https://doi.org/10.1080/17425255.2018.1420164
https://doi.org/10.1080/17425255.2018.1420164
Akademický článek
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Publikováno v:
Bioanalysis. 9:469-483
Aim: Optimal dosing of antibiotics in critically ill patients is complicated by the development of resistant organisms requiring treatment with multiple antibiotics and alterations in systemic exposure due to diseases and extracorporeal drug removal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0931f3603a4608158f67ccb414fde4
https://doi.org/10.4155/bio-2016-0157
https://doi.org/10.4155/bio-2016-0157
Autor:
S. Casey Laizure, Robert B. Parker
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 50(1)
The carboxylesterase drug hydrolysis pathway has been used extensively to improve the oral availability of drugs under the assumption that the high capacity and low substrate specificity of hydrolytic enzymes would ensure rapid, complete, and consist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4baa3fceffd24d9b8a9e148a16b6a1
https://pubmed.ncbi.nlm.nih.gov/31601149
https://pubmed.ncbi.nlm.nih.gov/31601149
Autor:
Joanna Q. Hudson, G. Christopher Wood, David M Hill, Angela Arnold-Ross, William L. Hickerson, Joseph M. Swanson, Zhe-Yi Hu, S. Casey Laizure, Bradley A. Boucher
Publikováno v:
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 36:1229-1237
tudy objective High-dose continuous venovenous hemofiltration (CVVH) is a continuous renal replacement therapy (CRRT) used frequently in patients with burns. However, antibiotic dosing is based on inference from studies assessing substantially differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8125dd949f08ee20764cbb33e39640a
https://doi.org/10.1002/phar.1866
https://doi.org/10.1002/phar.1866
Autor:
S. Casey Laizure
Publikováno v:
The APhA Complete Review for the Foreign Pharmacy Graduate Equivalency Examination, 2nd Edition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccc9a18d2393661785d522fa089bbc20
https://doi.org/10.21019/9781582122984.ch10
https://doi.org/10.21019/9781582122984.ch10
