Zobrazeno 1 - 10
of 26
pro vyhledávání: '"S C Strom"'
Publikováno v:
Toxicology and Applied Pharmacology. 126:98-107
In vivo exposure of B6C3F1 mice to the hepatotoxic chlorinated hydrocarbon, CCl4, suppresses T-cell-dependent humoral immune responses to sRBC. In the present studies, separation-crossover-reconstitution experiments with spleen cell subpopulations is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2fc5d90c4c908f1aca72f8b53e1d0ab
https://doi.org/10.1006/taap.1994.1095
https://doi.org/10.1006/taap.1994.1095
Publikováno v:
Methods in molecular medicine. 19
Research since 1983 has demonstrated that human hepatocytes can be isolated, cultured, and used for biological investigations, including studies of gene transcription and drug metabolism (1,2). In addition, the ability to cyropreserve hepatocytes has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b091891f51d7ff7b20f92f8295ab1d9d
https://pubmed.ncbi.nlm.nih.gov/21374391
https://pubmed.ncbi.nlm.nih.gov/21374391
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(11)
Milk thistle extract is one of the most commonly used nontraditional therapies, particularly in Germany. Milk thistle is known to contain a number of flavonolignans. We evaluated the effect of silymarin, on the activity of various hepatic drug-metabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::862610f8f4f17aaa9f79979338e200de
https://pubmed.ncbi.nlm.nih.gov/11038151
https://pubmed.ncbi.nlm.nih.gov/11038151
Autor:
V E, Kostrubsky, J F, Sinclair, V, Ramachandran, R, Venkataramanan, Y H, Wen, E, Kindt, V, Galchev, K, Rose, M, Sinz, S C, Strom
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(10)
In primary human and porcine hepatocyte cultures, we investigated the relationship between metabolism and cytotoxicity of troglitazone. Treatment of human hepatocytes for 2 h with 10, 20, 25, 35, and 50 microM troglitazone in protein-free medium resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9820ca34101ec5686ea506713c9b5f2b
https://pubmed.ncbi.nlm.nih.gov/10997939
https://pubmed.ncbi.nlm.nih.gov/10997939
Autor:
V, Ramachandran, V E, Kostrubsky, B J, Komoroski, S, Zhang, K, Dorko, J E, Esplen, S C, Strom, R, Venkataramanan
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(10)
Troglitazone (TRO) is an insulin sensitizer used in the treatment of type II diabetes. TRO is known to increase the activity of cytochrome P-450 (CYP) 3A in vivo. We have investigated the effect of TRO on CYP3A protein content and the activity of CYP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8369dbde377946244acb6ceab5794c4b
https://pubmed.ncbi.nlm.nih.gov/10497147
https://pubmed.ncbi.nlm.nih.gov/10497147
Autor:
V E, Kostrubsky, V, Ramachandran, R, Venkataramanan, K, Dorko, J E, Esplen, S, Zhang, J F, Sinclair, S A, Wrighton, S C, Strom
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(8)
We have previously reported that paclitaxel (Taxol) is a potent inducer of cytochrome P-450 (CYP) 3A protein and CYP3A mRNA in human hepatocyte cultures. Here we report that Taxol increased CYP3A-dependent testosterone 6beta-hydroxylation in intact h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8c7ab08c0c0524f67ed60c2caa277aad
https://pubmed.ncbi.nlm.nih.gov/10421615
https://pubmed.ncbi.nlm.nih.gov/10421615
Publikováno v:
Pharmacogenetics. 8(2)
The effect of ionic strength, assay constituents, alpha-naphthoflavone (aNF), terfenadine and testosterone on human CYP3A mediated midazolam (MDZ) 1'-hydroxylation (MDZ 1'-OH) and 4-hydroxylation (MDZ 4-OH) in vitro was examined. Increasing concentra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::efa3b3736e29a257ce0d354803b8e858
https://pubmed.ncbi.nlm.nih.gov/10022752
https://pubmed.ncbi.nlm.nih.gov/10022752
Publikováno v:
Molecular carcinogenesis. 18(4)
We have previously shown that rat liver epithelial cells (RLEC) transfected with and constitutively expressing transforming growth factor-alpha (TGF-alpha) have an enhanced mitogenic response to hepatocyte growth factor (HGF). In the study reported h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ee58de12c264db939cdfc25192675c4a
https://pubmed.ncbi.nlm.nih.gov/9142219
https://pubmed.ncbi.nlm.nih.gov/9142219
Publikováno v:
Methods in enzymology. 272
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fc0210b923d7b6c8b4078fbcbc469533
https://pubmed.ncbi.nlm.nih.gov/8791798
https://pubmed.ncbi.nlm.nih.gov/8791798
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 23(3)
We previously demonstrated that induction of hepatic cytochrome P4503A (CYP3A) immunoreactive protein is a response in rats, but not rabbits, treated with the antiglucocorticoid, pregnenolone 16 alpha-carbonitrile and in rabbits, but not rats, treate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::86fcdf138fc1274f760ae8c725de9d01
https://pubmed.ncbi.nlm.nih.gov/7628309
https://pubmed.ncbi.nlm.nih.gov/7628309