Zobrazeno 1 - 10
of 19
pro vyhledávání: '"S C Roerig"'
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 291(2)
Short-term morphine stimulates vagal bradycardia. This led us to propose the hypothesis that chronically administered morphine would down-regulate myocardial muscarinic receptor systems. Dogs received morphine continuously for 2 weeks through an s.c.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fa044f3007e5ae11a2efe7e5e74981b2
https://pubmed.ncbi.nlm.nih.gov/10525093
https://pubmed.ncbi.nlm.nih.gov/10525093
Autor:
Z Y, Wei, S C, Roerig
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 287(3)
When coadministered spinally, morphine and clonidine interact synergistically to produce antinociception. The mechanism for the synergism is unknown, but may depend on intracellular messenger systems. Agents that alter the activities of protein kinas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6edec2b3933087ca171c07872e7579f7
https://pubmed.ncbi.nlm.nih.gov/9864276
https://pubmed.ncbi.nlm.nih.gov/9864276
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 278(3)
When morphine and clonidine are coadministered into the spinal cord (intrathecally) the resulting antinociception is greater than would be expected if the drug responses were additive; thus, a synergistic interaction. The mechanism for this synergist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3836a3f55f7621ba198e27f3608c7338
https://pubmed.ncbi.nlm.nih.gov/8819527
https://pubmed.ncbi.nlm.nih.gov/8819527
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 262(1)
The nature of the interaction between spinally administered opioid and alpha-2 agonists was investigated using the substance P behavioral test in mice. Morphine and agonists which more selectively activate mu or delta opioid receptors were co-adminis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e18525b5580516c454ac343805f87cb6
https://pubmed.ncbi.nlm.nih.gov/1378095
https://pubmed.ncbi.nlm.nih.gov/1378095
Publikováno v:
Molecular pharmacology. 41(5)
Five separate guanine nucleotide-binding proteins (G proteins) were immunologically identified in membranes from neuroblastoma x glioma NG108-15 hybrid cells. These alpha subunit proteins were Gi2 alpha, two isoforms of Gi3 alpha, and two isoforms of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4f5f2e0fb9daa37c6cb0dda1c5fbaeb7
https://pubmed.ncbi.nlm.nih.gov/1317000
https://pubmed.ncbi.nlm.nih.gov/1317000
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 256(2)
The opioid receptor types involved in supraspinal and spinal heroin-induced analgesia in Swiss Webster and ICR mice were determined by intracerebroventricular (i.c.v.) and intrathecal (i.t.) administration of opioid agonists and antagonists. Also, co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f07bf38241806310f3c6ae272f19f5d2
https://pubmed.ncbi.nlm.nih.gov/1847196
https://pubmed.ncbi.nlm.nih.gov/1847196
Autor:
S C Roerig, Richard I. H. Wang, Nithiananda Chatterjie, Charles E. Inturrisi, James M. Fujimoto
Publikováno v:
Experimental Biology and Medicine. 148:443-448
SummaryA rabbit liver enzyme system was used to produce the 6β-OH reduced metabolites of naloxone and naltrexone. GC analysis indicated the presence of some 6α-0H metabolite in these samples. The narcotic antagonist activity of these 6β-OH metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ac876d06c386b6f76658a35500aeb6d
https://doi.org/10.3181/00379727-148-38558
https://doi.org/10.3181/00379727-148-38558
Publikováno v:
Journal of Pharmaceutical Sciences. 74:821-824
Morphine 3-sulfate, which carries a polar, acidic group at the 3-position much like morphine, does not differ greatly in analgesic potency from morphine following intracerebroventricular administration. This differs from the non-ionizable 3-methyl an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36eb5ba1f0871f6f5e4fbdb6c3432036
https://doi.org/10.1002/jps.2600740804
https://doi.org/10.1002/jps.2600740804
Publikováno v:
Science. 208:72-74
Mice implanted with morphine pellets demonstrated a 30-fold increase in tolerance to subcutaneously administered morphine but showed no cross-tolerance to subcutaneously administered heroin. When given morphine intracerebroventricularly, the mice sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7313d74c767dc66ac87e65573b70aa25
https://doi.org/10.1126/science.7361110
https://doi.org/10.1126/science.7361110
Autor:
S C, Roerig, J M, Fujimoto
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 247(2)
In the rat and mouse when morphine is coadministered intracerebroventricularly (i.c.v.) in the brain and intrathecally (i.t.) in the spinal cord, a multiplicative (synergistic) interaction occurs for the antinociceptive response. In the male Swiss Co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fae12510d7ac87df8e940b215942dba1
https://pubmed.ncbi.nlm.nih.gov/3183956
https://pubmed.ncbi.nlm.nih.gov/3183956