Zobrazeno 1 - 10
of 21
pro vyhledávání: '"S C O'Neill"'
Publikováno v:
Irish journal of medical science. 186(3)
Traditionally orthopaedic injections were performed in a theatre setting. A dedicated outpatient injection clinic was established at our institution to attempt to provide injections more cost effectively. Our aim was to perform a cost analysis of ort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86ed40bd20384422e7d196483949a947
https://pubmed.ncbi.nlm.nih.gov/28161738
https://pubmed.ncbi.nlm.nih.gov/28161738
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 295:H598-H609
Mechanical alternans in cardiac muscle is associated with intracellular Ca2+ alternans. Mechanisms underlying intracellular Ca2+ alternans are unclear. In previous experimental studies, we produced alternans of systolic Ca2+ under voltage clamp, eith
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3e388e2defdd40ca56d105fd022439
https://doi.org/10.1152/ajpheart.01086.2007
https://doi.org/10.1152/ajpheart.01086.2007
Publikováno v:
Cell Calcium
Graphical abstract
Highlights • The suitability of TBQ as a specific inhibitor of SERCA was investigated. • TBQ decreased SERCA activity in a concentration dependent manner. • TBQ inhibited the calcium current. • TBQ activated an outward
Highlights • The suitability of TBQ as a specific inhibitor of SERCA was investigated. • TBQ decreased SERCA activity in a concentration dependent manner. • TBQ inhibited the calcium current. • TBQ activated an outward
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8ece2496e225831853a8ade5d121ff7c
https://pubmed.ncbi.nlm.nih.gov/26120055
https://pubmed.ncbi.nlm.nih.gov/26120055
Autor:
S C O'Neill, David A. Eisner
Publikováno v:
The Journal of Physiology. 430:519-536
1. The fluorescent indicator Indo-1 was used to measure both [Ca2+]i and [caffeine]i in single ventricular myocytes. 2. Caffeine (at concentrations of 1 mM or above) produced a transient increase of resting [Ca2+]i attributed to the release of Ca2+ i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b630d4f00d7cecc627cb4c457583f07
https://doi.org/10.1113/jphysiol.1990.sp018305
https://doi.org/10.1113/jphysiol.1990.sp018305
Publikováno v:
American Journal of Physiology-Cell Physiology. 258:C1165-C1168
The aim of this paper was to examine whether contraction (which is thought to result from Ca-induced release of Ca2+ from the sarcoplasmic reticulum) can propagate along a cardiac cell. The experiments were performed on isolated rat ventricular cardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d332378ec696e6c3682ca68d0e15a946
https://doi.org/10.1152/ajpcell.1990.258.6.c1165
https://doi.org/10.1152/ajpcell.1990.258.6.c1165
Publikováno v:
The Journal of Physiology. 425:55-70
1. Fluorescence measurements have been made in single, isolated rat ventricular myocytes using the Ca2(+)-sensitive indicators Fura-2 and Indo-1. In Fura-2-loaded cells, the application of caffeine (2-20 mM) produced a change of fluorescence indicati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fec87b1b5b74d23eb546cf99ae4cc686
https://doi.org/10.1113/jphysiol.1990.sp018092
https://doi.org/10.1113/jphysiol.1990.sp018092
Publikováno v:
Experimental physiology. 90(1)
[Ca2+]i is used as a signal in many tissues. In this review we discuss the mechanisms that regulate [Ca2+]i and, importantly, what determines their stability. Brief mention is made of the effects of feedback gain and delays on stability. The control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6dcf1d5c10f43037929a290afeeef6a3
https://pubmed.ncbi.nlm.nih.gov/15572459
https://pubmed.ncbi.nlm.nih.gov/15572459
Publikováno v:
The Journal of physiology. 559(Pt 1)
Waves of calcium-induced calcium release occur in a variety of cell types and have been implicated in the origin of cardiac arrhythmias. We have investigated the effects of inhibiting the SR Ca(2+)-ATPase (SERCA) with the reversible inhibitor 2',5'-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc66a302d08569f098ff542280668991
https://pubmed.ncbi.nlm.nih.gov/15194743
https://pubmed.ncbi.nlm.nih.gov/15194743
Publikováno v:
Frontiers in bioscience : a journal and virtual library. 7
This review discusses the control of the amplitude of the cardiac systolic Ca transient. The Ca transient arises largely from release from the sarcoplasmic reticulum (SR). Release is triggered by calcium-induced calcium release (CICR) whereby the ent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61e953aa5abec6eee46b98f64ab4b337
https://pubmed.ncbi.nlm.nih.gov/11897570
https://pubmed.ncbi.nlm.nih.gov/11897570
Publikováno v:
Heart. 97:A96-A97
Introduction Iron overload-cardiomyopathy (IOCM) is an increasing clinical problem worldwide. 70% of patients who receive compulsory blood transfusion die of IOCM, with increased susceptibility to arrhythmias and sudden death. We have previously foun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9169c4ec48134243724dd6ffa19a1ad8
https://doi.org/10.1136/heartjnl-2011-300198.172
https://doi.org/10.1136/heartjnl-2011-300198.172