Pharmacodynamic genome-wide association study identifies new responsive loci for glucocorticoid intervention in asthma

Autor: Y Wang, C Tong, Z Wang, D Mauger, K G Tantisira, E Israel, S J Szefler, V M Chinchilli, H A Boushey, S C Lazarus, R F Lemanske, R Wu

Publikováno v: Wang, Y; Tong, C; Wang, Z; Wang, Z; Mauger, D; Tantisira, KG; et al.(2015). Pharmacodynamic genome-wide association study identifies new responsive loci for glucocorticoid intervention in asthma. Pharmacogenomics Journal. doi: 10.1038/tpj.2014.83. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/44r1f8tr
The pharmacogenomics journal, vol 15, iss 5

© 2015 Macmillan Publishers Limited Asthma is a chronic lung disease that has a high prevalence. The therapeutic intervention of this disease can be made more effective if genetic variability in patients’ response to medications is implemented. Ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113b0c50a5272709d37d0e5c30328db5
https://europepmc.org/articles/PMC6156797/

Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol: a randomized controlled trial

Autor: R F, Lemanske, C A, Sorkness, E A, Mauger, S C, Lazarus, H A, Boushey, J V, Fahy, J M, Drazen, V M, Chinchilli, T, Craig, J E, Fish, J G, Ford, E, Israel, M, Kraft, R J, Martin, S A, Nachman, S P, Peters, J D, Spahn, S J, Szefler

Publikováno v: JAMA. 285(20)

Inhaled long-acting beta(2)-agonists improve asthma control when added to inhaled corticosteroid (ICS) therapy.To determine whether ICS therapy can be reduced or eliminated in patients with persistent asthma after adding a long-acting beta(2)-agonist

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9b8c95dcb18989d7189179f3b7b52c69
https://pubmed.ncbi.nlm.nih.gov/11829556

Effect of polymorphism of the beta(2)-adrenergic receptor on response to regular use of albuterol in asthma

Autor: E, Israel, J M, Drazen, S B, Liggett, H A, Boushey, R M, Cherniack, V M, Chinchilli, D M, Cooper, J V, Fahy, J E, Fish, J G, Ford, M, Kraft, S, Kunselman, S C, Lazarus, R F, Lemanske, R J, Martin, D E, McLean, S P, Peters, E K, Silverman, C A, Sorkness, S J, Szefler, S T, Weiss, C N, Yandava

Publikováno v: International archives of allergy and immunology. 124(1-3)

Regular use of inhaled beta-adrenergic agonists may have adverse effects in some asthma patients. Polymorphisms of the beta(2)-adrenergic receptor (beta(2)-AR) can affect its regulation; however, results of smaller studies of the effects of such poly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9015511320f33c30858e90a8eb525ae3
https://pubmed.ncbi.nlm.nih.gov/11306963

An evaluation of colchicine as an alternative to inhaled corticosteriods in moderate asthma. National Heart, Lung, and Blood Institute's Asthma Clinical Research Network

Autor: J E, Fish, S P, Peters, C V, Chambers, S J, McGeady, K R, Epstein, H A, Boushey, R M, Cherniack, V M, Chinchilli, J M, Drazen, J V, Fahy, S S, Hurd, E, Israel, S C, Lazarus, R F, Lemanske, R J, Martin, E A, Mauger, C, Sorkness, S J, Szefler

Publikováno v: American journal of respiratory and critical care medicine. 156(4 Pt 1)

Colchicine demonstrates an array of anti-inflammatory properties of potential relevance to asthma. However, the efficacy of colchicine as an alternative to inhaled corticosteroid therapy for asthma is unknown. Five centers participated in a controlle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0e6a33aaf673db370e60085db8d04a6c
https://pubmed.ncbi.nlm.nih.gov/9351617

Mast cell chymase. A potent secretagogue for airway gland serous cells

Autor: C P Sommerhoff, G H Caughey, W E Finkbeiner, S C Lazarus, C B Basbaum, J A Nadel

Publikováno v: The Journal of Immunology. 142:2450-2456

Submucosal glands are the major sources of airway secretions in most mammals. Mast cells are abundant in the environment of airway submucosal glands and are rich sources of secreted proteases. To investigate the hypothesis that mast cell proteases st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94ceab624b2c9cb806f9ed65bebbc230
https://doi.org/10.4049/jimmunol.142.7.2450