Zobrazeno 1 - 10
of 20
pro vyhledávání: '"S C L, Gough"'
Publikováno v:
Diabetes, Obesity & Metabolism
Biosimilar insulins are likely to enter clinical practice in Europe in the near future. It is important that clinicians are familiar with and understand the concept of biosimilarity and how a biosimilar drug may differ from its reference product. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b37fa0c1bdbf4b9d28010658aa2007d9
https://doi.org/10.1111/dom.12410
https://doi.org/10.1111/dom.12410
Publikováno v:
Diabetes, Obesity and Metabolism. 15:301-309
All the basal insulin products currently available have suboptimal pharmacokinetic (PK) properties, with none reliably providing a reproducible and peakless pharmacodynamic (PD) effect that endures over 24 h from once-daily dosing. Insulin degludec i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9401cbe4660b69c3d83ceb40c47c0a4
https://doi.org/10.1111/dom.12052
https://doi.org/10.1111/dom.12052
The effect of heart rate on plasma fibrinolytic activity was investigated in nine patients with dual chamber cardiac pacemakers before and after 10 min of stimulated tachycardia to 123 beats/min. The results were compared to seven volunteers who perf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f5df19026463a84769c4b72fe1c6951
https://ora.ox.ac.uk/objects/uuid:b20932cf-3a1a-4f33-b7a8-1da6d845207e
https://ora.ox.ac.uk/objects/uuid:b20932cf-3a1a-4f33-b7a8-1da6d845207e
Autor:
S. C. L. Gough, Matthew J. Simmonds
Publikováno v:
Current Genomics
The HLA region encodes several molecules that play key roles in the immune system. Strong association between the HLA region and autoimmune disease (AID) has been established for over fifty years. Association of components of the HLA class II encoded
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8cedf0554ee49b95219d9ab0134e55c
Autor:
Michael C. Sheppard, J. M. Heward, A. Allahabadia, A. H. Barnett, Jayne Franklyn, S. C. L. Gough
Publikováno v:
Clinical Endocrinology. 51:115-118
OBJECTIVE The large multifunctional proteasome (LMP) molecules are over expressed in thyrocytes, the target cells of Graves' disease, and the LMP genes are found within the MHC class II region. The LMP genes may therefore play a role in susceptibilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12dbc49dcb524ab5f3cc7ce9c6ea1c9d
https://doi.org/10.1046/j.1365-2265.1999.00755.x
https://doi.org/10.1046/j.1365-2265.1999.00755.x
Autor:
S. C. L. Gough, Jayne Franklyn, JD Carr-Smith, A. H. Barnett, Joanne M. Heward, A. Allahabadia, Caroline Gordon, C. S. Cockram, Jacqueline Daykin
Publikováno v:
Clinical Endocrinology. 49:331-334
OBJECTIVE: The cytotoxic T lymphocyte associated-4 (CTLA-4) gene is a candidate for T-cell mediated autoimmune disease and polymorphism has been reported to be associated with both type 1 diabetes and autoimmune thyroid disease. A previously unreport
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9ba2a1bc0716d5b134c986f4abf8eaa
https://doi.org/10.1046/j.1365-2265.1998.00542.x
https://doi.org/10.1046/j.1365-2265.1998.00542.x
Autor:
R. Nithiyananthan, S. C. L. Gough, S. M. Gibson, Amit Allahabadia, Jayne A. Franklyn, Joanne M. Heward
Publikováno v:
Journal of Clinical Endocrinology & Metabolism. 86:3861-3863
Graves' disease (GD) is an autoimmune thyroid disease of unknown etiology, although predisposition to the development of this disease is thought to be caused by both genetic and environmental factors. Recently, an association between a promoter polym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::778a02367f213dd4ab5351ce5c185b6f
https://doi.org/10.1210/jc.86.8.3861
https://doi.org/10.1210/jc.86.8.3861
Autor:
Joanne M. Heward, Jayne A. Franklyn, Amit Allahabadia, S. C. L. Gough, A. H. Barnett, R. Nithiyananthan
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 85:1320-1322
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare monogenic autoimmune disease with endocrine components including type 1 diabetes, adrenal failure, and thyroid dysfunction, with major autoantibodies directed against a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84f47ab4d2aa414d92059a9cb47c1003
https://doi.org/10.1210/jcem.85.3.6465
https://doi.org/10.1210/jcem.85.3.6465
Autor:
Susan E. Manley, Irene M Stratton, Peter Nightingale, V. Baskar, Ken Sikaris, S. C. L. Gough, R. A. Round, Z. X. Lu
Publikováno v:
DIABETIC MEDICINE. 26(8)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd0db30412da1576c74db35b51befe71
http://ora.ox.ac.uk/objects/uuid:56864a5d-ccf0-4e87-b64e-e83e4ecf1777
http://ora.ox.ac.uk/objects/uuid:56864a5d-ccf0-4e87-b64e-e83e4ecf1777
Autor:
J. Tibaldi, S. C. L. Gough
Publikováno v:
Clinical drug investigation. 27(5)
The efficacy benefits of biphasic insulin aspart formulation (BIAsp 30) in patients with diabetes mellitus have been reported in several studies. BIAsp 30 has been shown to be more effective in terms of glycaemic control than standard biphasic human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7104ff5045f1f1e38b4f8fc18c3b2ff
http://ora.ox.ac.uk/objects/uuid:8cac82e7-ec0a-4d11-925f-c6f29f78bfda
http://ora.ox.ac.uk/objects/uuid:8cac82e7-ec0a-4d11-925f-c6f29f78bfda