Zobrazeno 1 - 10
of 35
pro vyhledávání: '"S C Hyde"'
Autor:
A. C. Boyd, Eric W.F.W. Alton, Stephanie G. Sumner-Jones, T Higgins, S C Hyde, Deborah R. Gill, Lee A. Davies, A Dayan, Gerry McLachlan, David J. Porteous, S H Cheng, Jane C. Davies, Uta Griesenbach, Ronald K. Scheule, J A Innes, Ian A. Pringle
Publikováno v:
Gene Therapy. 21:89-95
For gene therapy to improve lung function in cystic fibrosis (CF) subjects, repeated administration of the gene transfer agent over the lifetime of patients is likely to be necessary. This requirement limits the utility of adenoviral and adeno-associ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72372e01f57e2fb7b68ce17f954700d6
https://doi.org/10.1038/gt.2013.61
https://doi.org/10.1038/gt.2013.61
Long-term persistence of gene expression from adeno-associated virus serotype 5 in the mouse airways
Recombinant adeno-associated virus vectors based on serotype 2 (rAAV2) have been used to deliver transgenes to the airways in a variety of pre-clinical and clinical studies. Gene transfer in these studies has been severely restricted by the basolater
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4c20b6c34a9b0fa939dc85c430adaf8
https://doi.org/10.1038/sj.gt.3302815
https://doi.org/10.1038/sj.gt.3302815
The development of a successful gene therapy has many stages, including preclinical testing in animal models and proof of principle clinical studies. A variety of diseases affect the lung, which are candidates for gene therapy; this review will mainl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d671cf1ea48234e36eade770a5fd2f
https://doi.org/10.1007/s00018-003-3317-z
https://doi.org/10.1007/s00018-003-3317-z
Plasmid DNA (pDNA) expression vectors are fundamental to all forms of non-viral gene transfer. In this review, we discuss principles of pDNA design and production including the impact of bacterially derived sequences on transgene expression and minic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f16d63c68f632dccf84b96fe50f446ad
https://ora.ox.ac.uk/objects/uuid:734998e3-6657-46a8-bedb-44001caf0ece
https://ora.ox.ac.uk/objects/uuid:734998e3-6657-46a8-bedb-44001caf0ece
Autor:
J. Alastair Innes, Dominique McCormick, T Higgins, Heather E Davidson, Ronald K. Scheule, Deborah R. Gill, A. Christopher Boyd, Darren J. Shaw, Ian A. Pringle, Catherine Gordon, David J. Porteous, Eilidh Baker, Gerry McLachlan, Jane C. Davies, Rebecca Coles, S. C. Hyde, Eric W.F.W. Alton, Peter Tennant, David Collie, Uta Griesenbach, Alison Baker, Sionagh Smith, Michael McGovern, Stephanie G. Sumner-Jones, Seng H. Cheng, Christina Vrettou
Publikováno v:
Alton, E W, Baker, A, Baker, E, Boyd, C, Cheng, S H, Coles, R, Collie, D, Davidson, H, Davies, J C, Gill, D R, Gordon, C, Griesenbach, U, Higgins, T, Hyde, S C, Innes, J A, McCormick, D, McGovern, M, McLachlan, G, Porteous, D, Pringle, I A, Scheule, R K, Shaw, D, Smith, S, Summer-Jones, S, Tennant, P & Vrettou, C 2013, ' The safety profile of a cationic lipid-mediated cystic fibrosis gene transfer agent following repeated monthly aerosol administration to sheep ', Biomaterials, vol. 34, no. 38, pp. 10267-10277 . https://doi.org/10.1016/j.biomaterials.2013.09.023
Clinically effective gene therapy for Cystic Fibrosis has been a goal for over 20 years. A plasmid vector (pGM169) that generates persistent expression and reduced host inflammatory responses in mice has raised prospects for translation to the clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::193abd643570f53d00904ebe8e3517e4
https://doi.org/10.1016/j.biomaterials.2013.09.023
https://doi.org/10.1016/j.biomaterials.2013.09.023
Autor:
Duncan M. Geddes, Peter K. Jeffery, M. E. Goddard, M. Takata, S. C. Hyde, Eric W.F.W. Alton, Jean Williams, Jie Zhu, Hazel Painter, K Ulrich, M Stern, D. R. Gill, A. Dewar
Alveolar type II (ATII) cell proliferation and differentiation are important mechanisms in repair following injury to the alveolar epithelium. KGF is a potent ATII cell mitogen, which has been demonstrated to be protective in a number of animal model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95be5e7bb4d2466573229917e1204735
https://ora.ox.ac.uk/objects/uuid:04d83033-eb17-4f08-9b22-a359e72269a4
https://ora.ox.ac.uk/objects/uuid:04d83033-eb17-4f08-9b22-a359e72269a4
Autor:
S C Hyde, C. A. Goddard, Smyth Se, William H. Colledge, Deborah R. Gill, Ian A. Pringle, Christopher F. Higgins
Publikováno v:
Gene Therapy. 8:1539-1546
For effective gene therapy of chronic disease, persistent transgene expression at therapeutic levels is required. Clinical studies of airway gene transfer in patients with cystic fibrosis (CF) have resulted in short-lived transgene expression. We use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57db9b63e2b1e568b7331deecd9dd05e
https://doi.org/10.1038/sj.gt.3301561
https://doi.org/10.1038/sj.gt.3301561
Autor:
L. J. Andries, S. U. Sys, A. L. Meulemans, J. A. J. Schuurkes, B. Vanheel, J. Van de Voorde, P. De Smet, J. Li, W. Van Driessche, B. Flamion, S. Foulon, M. Abramow, P. Calders, W. Eechaute, E. Lacroix, I. Weyne, D. Hoeben, C. Burvenich, P. Fransen, D. Van Bedaf, M. Demolder, R. Ouedraogo, P. Lebrun, A. Herchuelz, M. -H. Antoine, S. Vandenput, D. Votion, N. Anciaux, D. H. Duvivier, T. Art, P. Lekeux, Y. Ghafir, M. Geurts, E. Hermans, J. -M. Maloteaux, B. Perrad, B. Noel, F. Lagache, J. L. Bister, R. Paquay, G. Derycke, M. A. Vandermeir, S. de Brouwer, C. -A. Porret, N. Stergiopulos, J. -J. Meister, M. Verbeke, N. Lameire, N. M. De Clerck, J. De Schuytter, J. Tytgato, G. Buyse, J. Eggermont, G. Droogmans, B. Nilius, P. Daenens, S. Salomone, O. Feron, C. Dessy, N. Morel, T. Godfraind, A. M. Aloisi, P. Sacerdote, L. Lodi, G. Carli, C. Carobi, G. Garinei, U. C. Miniaci, P. Scotto, M. Sabatino, P. Sardo, L. Iurato, V. La Grutta, M. A. Bagni, G. Cecchi, E. Cecchini, F. Colomo, P. Garzella, R. Bottinelli, S. D. H. Harridge, M. Canepari, C. Reggiani, Saltin Reggiani, D. Bambagioni, G. Fanò, G, Menchetti, P. Danieli-Betto, A. Esposito, R. Betto, A. Megighian, M. Midrio, D. Danieli Betto, C. Orizio, D. Liberati, C. Locatelli, D. De Grandis, A. Veicsteinas, D. Angoli, D. Delia, E. Wanke, M. Bramucci, A. Miano, L. Quassinti, E. Maccari, O. Murri, D. Amici, G. Cibelli, S. Jüngling, S. Schoch, H. H. Gerdest, G. Thiel, I. Demori, C. Bottazzi, A. Voci, E. Fugassa, A. Barreca, F. Minuto, G. Gallo, S. Fulle, S. Belia, G. Menchetti, M. Cacchio, G. Gastaldi, U. Laforenza, G. Ferrari, G. Rindi, M. G. Doni, E. Padoin, O. Residori, M. Cesaro, L. Toma, A. Rubini, F Mutinelli, L. Paulesu, R. Romagnolie, M. Cintorino, P. Pippia, M. A. Meloni, L. Sciola, A. Spano, M. Cogoli-Greuter, A. Cogoli, A. Sardini, G. M. Mintenig, M. A. Valverde, F. V. Sepùlveda, D. R. Gill, S. C. Hyde, C. F. Higgins, P. A. McNaughton, A. Spena, M. T. Arcuri, S. Bonofiglio, R. Chimenti, C. Covello, T. De Cicco, S. Mazzulla, G. Martino, A. Tottene, A. Moretti, D. Pietrobon, M. C. Baccari, F. Calamai, G. Staderini, E. Cova, R. Marelli, P. Sommi, U. Ventura, A. M. Lombardi, R. Fabris, C. Pagano, G. Federspil, R. Vettor, R. Mancinelli, P. Tonali, S. Servidei, R. Romani, A. Tringali, G. B. Azzena, F. Mulè, R. Serio, A. Postorino, M. Rizzato, M. Granzotto, V. Ricci, M. Romano, K. J. Ivey, G. Vacca, B. Papillo, D. A. S. G. Mary, A. Battaglia, E. Grossini, E. A. Accili, G. Redaelli, D. DiFrancesco, S. Antoniotti, C. Distasi, D. Lovisolo, L. Munaron, F. Bertaso, R. Assandri, M. Mazzanti, L. Bianchi, A. Arcangeli, L. Faravelli, A. Becchetti, M. Coronello, E. Mini, F. Francini, M. Olivotto, A. Bigiani, D. -J. Kim, S. D. Roper, V. Carabelli, M. Lovallo, V. Magnelli, H. Zucker, E. Carbone, E. D’Angelo, P. Rossi, G. De Filippi, V. Taglietti, C. Bencini, R. Squecco, E. Guatteo, A. Bacci, S. Franceschetti, G. Avanzini, A. Ferroni, A. Navangione, V. Vellani, G. Rispoli, A. Peres, E. Centinaio, S. Giovannardi, G. Russo, W. Marcotti, I. Prigioni, C. Trequattrini, A. A. Harper, A. Petris, F. Franciolini, A. Zaza, M. Micheletti, A. Brioschi, G. Antonutto, C. Capelli, M. Girardis, P. Zamparo, P. E. di Prampero, D. Tuniz, G. M. Filippi, D. Troiani, B. Grassi, D. C. Poole, R. S. Richardson, D. R. Knight, B. K. Erickson, P. D. Wagner, B. Aimi, D. Stilli, P. Gallo, A. Sgoifo, C. Lagrasta, G. Olivetti, N. Reali, A. Casti, E. Musso, G. Alloatti, C. Penna, M. P. Gallo, R. C. Levi, I. Fenoglio, G. Appendino, D. Medici, M. Manghi, E. Pasini, C. Ceconi, F. Baldissera, P. Cavallari, M. Locatelli, R. Bartesaghi, T. Gessi, F. Benfenati, F. Valtorta, F. Onofri, M. Poo, P. Greengard, G. Biagini, D. Sala, P. Viani§, A. V. Kozlov, I. Zini, M. Bravin, F. Tempia, P. Strata, G. Brescia, C. Di Benedetto, P. Corsi, G. Cangiano, M. Buttiglione, M. Ambrosini, G. Gennarini, A. Casadio, P. G. Montarolo, P. Cesare, R. Stoughton, G. D’Arcangelo, H. U. Dodt, A. Brancati, W. Zieglgänsberger, P. Errico, A. Ferraresi, N. H. Barmack, V. E. Pettorossi, S. Gasparini, R. D’Ambrosio, D. Janigro, I. Gritti, M. Marintti, R. Calcaterra, R. Freddi, M. Mancia, I. Imeri, S. Bianchi, F. Lui, K. M. Gregory, R. H. I. Blanks, R. A. Giolli, C. Benassi, R. Corazza, P. C. Magherini, R. Bardoni, O. Belluzzi, E. Manni, M. Diana, W. Fratta, D. Manzoni, P. Andre, O. Pompeiano, R. Mazzocchio, A. Rossi, F. Melis, A. Kitura, M. A. Caria, H. Asanuma, M Melone, S De Biasi, A Minelli, F Conti, C Karschin, S DeBiasi, N C Brecha, M. Monda, S. Amaro, A. Sullo, B. De Luca, M. R. Pantò, F. Cicirata, R. Parenti, M. F. Serapide, M. Wassef, M. V. Podda, A. Solinas, G. Chessa, F. Deriu, O. Mameli, E. Tolu, C. A. Porro, M. P. Francescato, V. Cettolo, M. E. Diamond, P. Baraldi, M. Bazzocchi, R. Rivosecchi, A. Konnerth, M. L. Rossi, M. Martini, B. Pelucchi, R. Fesce, L. Santarelli, S. Schacher, R. Santarelli, C. Grassi, A. Valente, S. Nisticò, G. Bagetta, Rossana Scuri, Mercedes Garcia-Gil, Riccardo Mozzachiodi, Marcello Brunelli, G. Stefani, P. Vaccaro, H. B. Nielander, V. Tancredi, M. D’Antuono, A. Siniscalchi, M. Avoli, L. Verzè, A. Buffo, F. Rossi, A. B. Oestreicher, W. H. Gispen, G. Zamboni, R. Amici, C. A. Jones, E. Perez, R. Domeniconi, P. L. Parmeggiani, Michele Zoli, Nicolas Le Novàre, Jean -Pierre Changeux, C. L. Lafortuna, E. Reinach, F. Saibene, L. Zocchi, E. Agostoni, D. Cremaschi
Publikováno v:
Pflügers Archiv. 431:R322-R356
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::725ea0729a155631546fd74d6b1e6a17
https://doi.org/10.1007/bf03036120
https://doi.org/10.1007/bf03036120
Autor:
Jun You, Angela Kerton, J. Alastair Innes, Mamoru Hasegawa, Amelia Shoemark, Mario Chan, T Higgins, Jane C. Davies, S. C. Hyde, Andrea Brum, Deborah R. Gill, Makoto Inoue, Eric W.F.W. Alton, Raymond Farley, David J. Porteous, Cuixiang Meng, A. Christopher Boyd, Nikki K. Newman, Uta Griesenbach
Publikováno v:
Griesenbach, U, Inoue, M, Meng, C, Farley, R, Chan, M, Newman, N K, Brum, A, You, J, Kerton, A, Shoemark, A, Boyd, A C, Davies, J C, Higgins, T E, Gill, D R, Hyde, S C, Innes, J A, Porteous, D J, Hasegawa, M & Alton, E W F W 2012, ' Assessment of F/HN-Pseudotyped Lentivirus as a Clinically Relevant Vector for Lung Gene Therapy ', American Journal of Respiratory and Critical Care Medicine, vol. 186, no. 9, pp. 846-856 . https://doi.org/10.1164/rccm.201206-1056OC
Rationale. Ongoing efforts to improve pulmonary gene transfer thereby enabling gene therapy for the treatment of lung diseases, such as cystic fibrosis (CF), has led to the assessment of a lentiviral vector (simian immunodeficiency virus [SIV]) pseud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b3e23e190dc8c1f747a41ffb722c93
http://ora.ox.ac.uk/objects/uuid:ffeef975-7c8b-432e-a92e-d8e47b1384e2
http://ora.ox.ac.uk/objects/uuid:ffeef975-7c8b-432e-a92e-d8e47b1384e2
Autor:
David Collie, Uta Griesenbach, Laura Hyndman, A. C. Boyd, Heather E Davidson, David J. Porteous, Stephanie G. Sumner-Jones, Ronald K. Scheule, Gerry McLachlan, Abigail R. Wilson, S C Hyde, Catherine Gordon, Darren J. Shaw, Christina Vrettou, J A Innes, R. Blundell, Ian A. Pringle, Emma Holder, Ann Doherty, Jane C. Davies, Alison Baker, Eric W.F.W. Alton, Lee A. Davies, Deborah R. Gill, S H Cheng, Rebecca Coles, Peter Tennant, Barbara J Stevenson, Hazel Painter
Publikováno v:
Gene therapy. 18(10)
We use both large and small animal models in our pre-clinical evaluation of gene transfer agents (GTAs) for cystic fibrosis (CF) gene therapy. Here, we report the use of a large animal model to assess three non-viral GTAs: 25 kDa-branched polyethylen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::430eaa691aebb1e78eab6ab7221960e5
http://ora.ox.ac.uk/objects/uuid:5e5123f5-13ed-440b-944d-3ceb5d07482e
http://ora.ox.ac.uk/objects/uuid:5e5123f5-13ed-440b-944d-3ceb5d07482e