Výsledky vyhledávání - "S C, van der Schoot"

Purity profile of the indoloquinone anticancer agent EO-9 and chemical stability of EO-9 freeze dried with 2-hydroxypropyl-beta-cyclodextrin

Autor: S C, van der Schoot, L D, Vainchtein, B, Nuijen, A, Gore, D, Mirejovsky, L, Lenaz, J H, Beijnen

Publikováno v: Die Pharmazie. 63(11)

Two new bladder instillations of the investigational anticancer agent EO-9 containing 2-hydroxypropyl-beta-cyclodextrin (HP beta CD) and the alkalizers sodium bicarbonate (NaHCO3) and tri(hydroxymethyl)aminomethane (Tris) were developed. During the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b846894458a4843d456a87cd77737b3c
https://pubmed.ncbi.nlm.nih.gov/19069239

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Complexation study of the anticancer agent EO-9 with 2-hydroxypropyl-beta-cyclodextrin

Autor: J. H. Beijnen, Dorla Mirejovsky, Luigi Lenaz, Frits M. Flesch, S. C. van der Schoot, Bastiaan Nuijen, Ashok Gore

Publikováno v: Drug development and industrial pharmacy. 34(10)

For the development of a bladder instillation of the indoloquinone agent EO-9, use of the complexing agent 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) was considered. Therefore, a complexation study of EO-9 with HPbetaCD was performed. Complexation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4430adbe98c6db078545b5cb2203cced
https://pubmed.ncbi.nlm.nih.gov/18663657

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Pharmaceutical development, quality control, stability and compatibility of a parenteral lyophilized formulation of the investigational polymer-conjugated platinum antineoplastic agent AP5346

Autor: S C, Van der Schoot, B, Nuijen, P, Sood, K B, Thurmond, D R, Stewart, J R, Rice, J H, Beijnen

Publikováno v: Die Pharmazie. 61(10)

AP5346 is a low molecular weight polymer-conjugated platinum antineoplastic agent. The lyophilized drug product has completed a phase I clinical trial. In order to guarantee a constant quality of AP5346 pharmaceutical products, quality control and an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bd288c7c02d21904919950502e9604db
https://pubmed.ncbi.nlm.nih.gov/17069422

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Assessment of performance of manufacturing procedures in a unit for production of investigational anticancer agents, using a mixed effects analysis

Autor: Jos H. Beijnen, Bastiaan Nuijen, S. C. van der Schoot, A. D. R. Huitema

Publikováno v: Pharmaceutical Research

Purpose To identify the magnitude and sources of variability of a generic, aseptic manufacturing process for experimental anticancer agents employed at our facility, and to estimate the effects on product quality. Materials and Methods In-process and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6389441fc8125569a8d510cad3755896
https://pubmed.ncbi.nlm.nih.gov/17245647

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