Zobrazeno 1 - 10
of 74
pro vyhledávání: '"S C, Vashishtha"'
Publikováno v:
Cellular and Molecular Neurobiology. 18:437-445
1. Apoptosis as the mechanism of cell death induced by a new cytotoxic and anticancer agent (N.C.1213) was investigated by morphological and biochemical criteria in human Jurkat T leukemia cells. 2. The effect of N.C.1213 on the survival of Jurkat T,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::605055339f12ad6d11d12e5dceb9099d
https://doi.org/10.1023/a:1022505700642
https://doi.org/10.1023/a:1022505700642
Autor:
P U Devi, Ravindra Kamath, S. C. Vashishtha, S. A. Patil, Nayanabhirama Udupa, Jonathan R. Dimmock, S. B. Dinesh
Publikováno v:
ChemInform. 30
A series of 1-aryl-2-dimethylaminomethyl-2-propen-1-one hydrochlorides demonstrated marked cytotoxicity towards approximately 55 human tumour cell lines from different neoplastic diseases. In general they were more potent than melphalan and displayed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43bd58004279cbc9404efe50461b3a65
https://doi.org/10.1002/chin.199904085
https://doi.org/10.1002/chin.199904085
Autor:
J. W. Quail, Jonathan R. Dimmock, S. C. Vashishtha, Theresa M. Allen, A. M. Sudom, E. De Clercq, Jan Balzarini, Z. Zimpel, G. Y. Kao, U. Pugazhenthi
Publikováno v:
ChemInform. 30
The syntheses of a series of 1-aryl-5-diethylamino-1-penten-3-one hydrochlorides 1 and 1-aryl-3-diethylamino-1-propanone hydrochlorides 4 were accomplished. Attempts to prepare the corresponding bis(5-aryl-3-oxo-4-pentenyl)ethylamine hydrochlorides 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b1c7cd79e6a2662556fb8c09f785404c
https://doi.org/10.1002/chin.199911144
https://doi.org/10.1002/chin.199911144
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 38(5)
1. Prazosin, 2-[4-(2-furanoyl)-piperazin-1-yl]-4-amino-6,7-dimethoxyquinazoline, is an antihypertensive agent that has been used safely since 1976 and is currently being investigated for the treatment of post-traumatic stress disorder. The in vivo me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::241bc4bec46793e6b51a8f00c4fd7c2e
https://pubmed.ncbi.nlm.nih.gov/18421626
https://pubmed.ncbi.nlm.nih.gov/18421626
Autor:
J R, Dimmock, G A, Zello, S C, Vashishtha, S J, Hayes, S, Mutalik, S, Kumar, M, Venkatesh, N, Udupa
Publikováno v:
Die Pharmazie. 58(2)
2-Dimethylaminomethyl-1-phenyl-2-propen-1-one hydrochloride (3) is a novel cytotoxic and anticancer agent. The objective of this study was to obtain information pertaining to possible toxic symptoms detected by in vivo evaluations in mice and an in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::52a8b1b4e06fd2d9758c0bfd921f474e
https://pubmed.ncbi.nlm.nih.gov/12641332
https://pubmed.ncbi.nlm.nih.gov/12641332
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(12)
The formation of the N1-glucuronide metabolite of each nicotine enantiomer was studied in pooled human liver microsomes (n = 6). The metabolite formed from natural S(-)-nicotine was identified by comparison of the high-pressure liquid chromatography
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b003764b5a74240875782f50adafe2f5
https://pubmed.ncbi.nlm.nih.gov/11717169
https://pubmed.ncbi.nlm.nih.gov/11717169
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(10)
A series of eight 1-substituted imidazoles was investigated as model substrates for glucuronidation at an aromatic tertiary amine of polyaza heterocyclic ring systems. The human UDP-glucuronosyltransferases (UGTs) involved and substrate specificities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c5a5c626231f4919b078069df88bfa35
https://pubmed.ncbi.nlm.nih.gov/11560872
https://pubmed.ncbi.nlm.nih.gov/11560872
Autor:
S C, Vashishtha, T M, Allen, S, Halleran, J, Szydlowski, C L, Santos, E, De Clercq, J, Balzarani, J R, Dimmock
Publikováno v:
Die Pharmazie. 56(5)
A previous investigation revealed that various 4-aryl-3-arylcarbonyl-1-ethyl-4-piperidinols and related vinylogs were cytotoxic to both murine and human tumour cell lines. In particular, 1a and 2a were identified as useful prototypic molecules. Struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::620a40150aec4e6d76ac5127d1a18ed3
https://pubmed.ncbi.nlm.nih.gov/11400554
https://pubmed.ncbi.nlm.nih.gov/11400554
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(9)
1-Phenylimidazole was investigated as a potential model substrate with respect to formation of a quaternary ammonium-linked glucuronide (N(+)-glucuronide) at an aromatic type tertiary amine. A reference sample of the potential N(+)-glucuronide metabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5ee67be2e71ea5b98229396674739692
https://pubmed.ncbi.nlm.nih.gov/10950841
https://pubmed.ncbi.nlm.nih.gov/10950841
Publikováno v:
Die Pharmazie. 55(7)
The results from a previous study led to the postulate that a number of aryl semicarbazones displaying anticonvulsant activity in the maximal electroshock (MES) screen interacted at both a hydrophobic and a hydrogen bonding areas on a specific bindin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::be743cdac82fcf0642c504392682f194
https://pubmed.ncbi.nlm.nih.gov/10944774
https://pubmed.ncbi.nlm.nih.gov/10944774