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189P Pharmacokinetics (PK) of sacituzumab govitecan (SG) in patients (Pts) with metastatic triple-negative breast cancer (mTNBC) and other solid tumors

Autor: A.G. Sathe, I. Singh, P. Singh, P. Diderichsen, X. Wang, P. Chang, S-C. Phan, S. Girish, A.A. Othman

Publikováno v: Annals of Oncology. 33:S214

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::239dad35cf45b47d761047566fada2c2
https://doi.org/10.1016/j.annonc.2022.03.208

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Akademický článek

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Pilot study with weekly chemotherapy for patients with extensive small cell lung cancer: an Eastern Cooperative Oncology Group Study (PA586)

Autor: A R, Yuen, J Z, Fuks, D S, Ettinger, A Y, Chang, J C, Ruckdeschel, S C, Phan, R H, Blum

Publikováno v: The cancer journal from Scientific American. 6(1)

Six of the most active chemotherapy agents in small cell lung cancer were administered sequentially in a weekly fashion in an attempt to optimize the dose and the number of agents received over a 12-week period. The purpose of this study was to estim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8bc360eddc74e4e36ab3e36f3718b944
https://pubmed.ncbi.nlm.nih.gov/10696737

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Decreased levels of 1,2-sn-diacylglycerol in human colon tumors

Autor: S C, Phan, M, Morotomi, J G, Guillem, P, LoGerfo, I B, Weinstein

Publikováno v: Cancer research. 51(5)

We have found that in 15 of 15 primary human colon tumors there was a significant decrease (by about 40%) in the levels of diacylglycerol when compared to paired adjacent normal mucosa samples. Assays on the same samples indicated that this decrease

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9de6f7a2e13c6490cf768f7b5c328521
https://pubmed.ncbi.nlm.nih.gov/1997199

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Goserelin plus anastrozole in the treatment of premenopausal hormone receptor positive, recurrent or metastatic breast cancer

Autor: E. K. Dice, Christine M. Schurman, Eva Thomas, S. C. Phan, Vicente Valero, Robert W. Carlson, Edgardo Rivera, Cathie T. Chung

Publikováno v: Journal of Clinical Oncology. 25:1030-1030

1030 Background: Aromatase inhibitors (AIs) are highly active in postmenopausal women with hormone receptor positive breast cancer. However, the AIs do not suppress ovarian estrogen synthesis and are not effective in premenopausal women. This phase I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3d67921a1a1395fc08d324623172b6e8
https://doi.org/10.1200/jco.2007.25.18_suppl.1030

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Phase II trial of motexafin gadolinium (MGd) for treatment of metastatic renal cell carcinoma (MRCC)

Autor: Robert J. Amato, S.-C. Phan, J. Hernandez, J. Jac

Publikováno v: Journal of Clinical Oncology. 24:14518-14518

14518 Background: MGd inhibits thioredoxin reductase. Thioredoxin is implicated in activation of hypoxia-inducible factor-1 alpha, which is overexpressed in >85% of renal cell carcinomas (RCC). We evaluated anti-tumor and safety activity of MGd in pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca68c1cec91d69d811d69190fd9879cc
https://doi.org/10.1200/jco.2006.24.18_suppl.14518

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Combination motexafin gadolinium (MGd) and docetaxel is active in recurrent lung and other solid tumors: Results of a phase 1 trial

Autor: K. J. Pandya, S. C. Phan

Publikováno v: Journal of Clinical Oncology. 23:3138-3138

3138 Background: MGd is a novel anti-neoplastic agent that targets tumors and generates reactive oxygen species (ROS) by redox cycling. Pre-clinical models show that MGd enhances the cytotoxic acti...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3af7ec4b6d6566c72c9d95191b33759
https://doi.org/10.1200/jco.2005.23.16_suppl.3138

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A phase 1 trial of motexafin gadolinium and docetaxel for advanced solid tumors

Autor: Patrick J. Creaven, N. Ramnath, M. Egorin, G. Chatta, S.-C. Phan

Publikováno v: Journal of Clinical Oncology. 22:3171-3171

3171 Background: Motexafin gadolinium (MGd) is a redox mediator that selectively targets tumor cells, producing reactive oxygen species. In preclinical models, MGd enhances the activity of several ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c3ab9031dc1e40ad2bd598649425db36
https://doi.org/10.1200/jco.2004.22.90140.3171

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