Zobrazeno 1 - 10
of 24
pro vyhledávání: '"S C, Perricone"'
Publikováno v:
Methods and findings in experimental and clinical pharmacology. 17(4)
U-37883A is a K+ sparing diuretic which selectively blocks openers of vascular ATP-sensitive K channels. Many N'-disubstituted morpholinoguanidine (N'-DMG) analogs of U-37883A were synthesized and tested for diuretic activity. In conscious rats, 10-1
Autor:
J. K. Gibson, Jackson B. Hester, M. G. Cimini, B. E. West, Louis L. Skaletzky, P. K. Locker, J. K. Sykes, D. E. Emmert, S. C. Perricone
Publikováno v:
Journal of medicinal chemistry. 34(1)
N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamid e, (E)-2-butenedioate (2:1) salt (ibutilide fumarate, 2E), has been found to have Class III antiarrhythmic activity. In an in vitro rabbit heart tissue preparation designed to evaluat
Autor:
Patrick J. Delehanty, Bharat V. Kamdar, Piper Richard C, Louis L. Skaletzky, S. C. Perricone, R. E. TenBrink, John M. McCall
Publikováno v:
Journal of Medicinal Chemistry. 29:133-137
A family of 7-(trifluoromethyl)-4-aminoquinolines that are hypotensive agents and that act by a novel sympatholytic mechanism is described. Structure-activity relationships in this series have been elucidated. Some of the more potent hypotensives wer
Publikováno v:
Organic Mass Spectrometry. 1:151-166
The mass spectra of the different forms of vitamin B6, some metabolites and antimetabolites, and some analogs are reported. The free bases are suitable for study, but the 5-phosphates are not sufficiently volatile. The hydrochloride salts dissociate
Publikováno v:
Journal of Heterocyclic Chemistry. 7:537-542
The 1,4-cycloaddition of 2,3-dihydro-5-methylfuran (II) to 1-acetyl-1,2,3,4-te trahydro-6-[(p-hydroxybenzylidene)amino]quinoline (VIII) in the presence of boron trifluoride gave two pairs of epimers, namely dl-10-acetyl-2,3,3a,4,5,7,8,9,10,11b-decahy
Publikováno v:
Journal of Heterocyclic Chemistry. 7:135-138
The boron trifluoride catalyzed 1,4-addition of 2,3-dihydro-5-methylfuran to N-(p-methoxy-benzylidene)-1,4-benzodioxan-6-amine (II) gave 2 pairs of epimers, 2,3,3a,4,5,8,9,11b-octahydro-4-(p-methoxyphenyl)-11b-methyl-p-dioxino[2,3-g]furo[3,2-c]quinol
Autor:
R. H. Wheelock, Donald F. Worth, H. Veloso, S. C. Perricone, Doris Potoczak, J. R. McLean, Neil F. Haley, Edward F. Elslager
Publikováno v:
Journal of Medicinal Chemistry. 14:782-788
Publikováno v:
Journal of Heterocyclic Chemistry. 5:609-613
Catalytic reductive scission of phthalazine (II) utilizing a two-stage palladium-Raney nickel procedure afforded o-xylene-α,α′-diamine (III) in 97% yield. Treatment of III with carbon disulfide gave [o-(aminomethyl)benzyl]dithiocarbamic acid (IV)
Publikováno v:
Journal of Medicinal Chemistry. 12:965-969
Publikováno v:
Journal of Heterocyclic Chemistry. 7:543-553
Various 2-alkoxy 7-chloro-10-[[[(dialkylamino)alkyl]amino]]benzo[b][1,5]naphthyridines (XI) and N-oxides (XV, XVII, XVIII, XXII), 4-[(2-alkoxy-7-chlorobenzo[b][1,5]naphthyridin-10-yl)-amino]-α-(diethylamino)-o-cresol derivatives (XII-XIV, XXI) and N