A Novel Ubiquitin Ligase Adaptor PTPRN Suppresses Seizure Susceptibility through Endocytosis of NaV1.2 Sodium Channels.

Autor: Wang, Yifan^1,2 (AUTHOR), Yang, Hui^1,2 (AUTHOR), Li, Na^1,2 (AUTHOR), Wang, Lili^1,2 (AUTHOR), Guo, Chang^1,2 (AUTHOR), Ma, Weining³ (AUTHOR), Liu, Shiqi^1,2 (AUTHOR), Peng, Chao^1,2 (AUTHOR), Chen, Jiexin^1,2 (AUTHOR), Song, Huifang^1,2 (AUTHOR), Chen, Hedan^1,2 (AUTHOR), Ma, Xinyue^1,2 (AUTHOR), Yi, Jingyun^1,2 (AUTHOR), Lian, Jingjing^1,2 (AUTHOR), Kong, Weikaixin^1,2 (AUTHOR), Dong, Jie^1,2 (AUTHOR), Tu, Xinyu^1,2 (AUTHOR), Shah, Mala⁴ (AUTHOR), Tian, Xin⁵ (AUTHOR) xintian@cqmu.edu.cn, Huang, Zhuo^1,2 (AUTHOR) huangz@hsc.pku.edu.cn

Publikováno v: Advanced Science. 8/7/2024, Vol. 11 Issue 29, p1-20. 20p.

Evidence for direct interaction of Gs alpha with the Ca2+ channel of skeletal muscle

Autor: Enrico Stefani, Juan Codina, L. Toro, F M Strickland, A M Spiegel, Atsuko Yatani, T Sawada, S C Froehner, Susan L. Hamilton, M. J. Hawkes

Publikováno v: Journal of Biological Chemistry. 266:19528-19535

The alpha subunits of heterotrimeric GTP-binding (G) proteins act upon ion channels through both cytoplasmic and membrane-delimited pathways (Brown, A. M., and Birnbaumer, L. (1990) Annu. Rev. Physiol. 52, 197-213). The membrane pathway may involve e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4018348df961971805eaef79acbbd20
https://doi.org/10.1016/s0021-9258(18)55027-4

beta-dystrobrevin, a new member of the dystrophin family. Identification, cloning, and protein associations

Autor: M F, Peters, K F, O'Brien, H M, Sadoulet-Puccio, L M, Kunkel, M E, Adams, S C, Froehner

Publikováno v: The Journal of biological chemistry. 272(50)

Dystrophin, the protein disrupted in Duchenne muscular dystrophy, is one of several related proteins that are key components of the submembrane cytoskeleton. Three dystrophin-related proteins (utrophin, dystrophin-related protein-2 (DRP2), and dystro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::169b00347b106f382e8a49f58b747148
https://pubmed.ncbi.nlm.nih.gov/9395493

beta 2-Syntrophin: localization at the neuromuscular junction in skeletal muscle

Autor: M F, Peters, N R, Kramarcy, R, Sealock, S C, Froehner

Publikováno v: Neuroreport. 5(13)

The syntrophins are a multigene family of proteins which bind C-terminal domains of dystrophin, utrophin and homologs thereof. We report here that antibodies specific for one isoform, beta 2-syntrophin, labeled only the neuromuscular junction (NMJ) i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7754eb25a6d4dd23413d4943680311a1
https://pubmed.ncbi.nlm.nih.gov/7819523

Association of the Mr 58,000 postsynaptic protein of electric tissue with Torpedo dystrophin and the Mr 87,000 postsynaptic protein

Autor: M H, Butler, K, Douville, A A, Murnane, N R, Kramarcy, J B, Cohen, R, Sealock, S C, Froehner

Publikováno v: The Journal of biological chemistry. 267(9)

Dystrophin was purified by immunoaffinity chromatography from detergent-solubilized Torpedo electric organ postsynaptic membranes using monoclonal antibodies. A major doublet of proteins at Mr 58,000 and minor proteins at Mr 87,000, Mr 45,000, and Mr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8304860b1d79b3bd1fa31beca0da54f0
https://pubmed.ncbi.nlm.nih.gov/1556129