Výsledky vyhledávání - "S Baekkeskov"

Akademický článek

Neuronal growth regulator 1 (NEGR1) promotes the synaptic targeting of glutamic acid decarboxylase 65 (GAD65).

Autor: Su F; School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, New South Wales, Australia., Pfundstein G; School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, New South Wales, Australia., Sah S; School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, New South Wales, Australia., Zhang S; School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, New South Wales, Australia., Keable R; School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, New South Wales, Australia., Hagan DW; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida, USA., Sharpe LJ; School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, New South Wales, Australia., Clemens KJ; School of Psychology, The University of New South Wales, Sydney, New South Wales, Australia., Begg D; School of Psychology, The University of New South Wales, Sydney, New South Wales, Australia., Phelps EA; J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida, USA., Brown AJ; School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, New South Wales, Australia., Leshchyns'ka I; School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, New South Wales, Australia., Sytnyk V; School of Biotechnology and Biomolecular Sciences, The University of New South Wales, Sydney, New South Wales, Australia.

Publikováno v: Journal of neurochemistry [J Neurochem] 2025 Jan; Vol. 169 (1), pp. e16279.

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A non-cleavable mutant of Fas ligand does not prevent neutrophilic destruction of islet transplants

Autor: S M, Kang, D, Braat, D B, Schneider, R W, O'Rourke, Z, Lin, N L, Ascher, D A, Dichek, S, Baekkeskov, P G, Stock

Publikováno v: Transplantation. 69(9)

Fas ligand (FasL) mediates apoptosis of susceptible Fas-expressing lymphocytes, and may contribute to the maintenance of peripheral tolerance. In transplantation models, however, artificial expression of FasL on cellular as well as islet transplants

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::67acd6e74a23ee9efd2fe97b8e89183b
https://pubmed.ncbi.nlm.nih.gov/10830216

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A dendritic cell line genetically modified to express CTLA4-IG as a means to prolong islet allograft survival

Autor: R W, O'Rourke, S M, Kang, J A, Lower, S, Feng, N L, Ascher, S, Baekkeskov, P G, Stock

Publikováno v: Transplantation. 69(7)

Dendritic cells are potent antigen-presenting cells that bind allogeneic T cells. They are thus candidates for targeting immunoregulatory molecules to the alloreactive T cell compartment and suppressing the alloimmune response.A dendritic cell line d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9de872115911a8e35f5b9c7c136c39c0
https://pubmed.ncbi.nlm.nih.gov/10798768

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Glutamate decarboxylase and GABA in pancreatic islets: lessons from knock-out mice

Autor: Brian G. Condie, S. Baekkeskov, S. F. Kash

Publikováno v: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 31(5)

The GABA-synthesizing enzyme glutamic acid decarboxylase (GAD) is expressed in pancreatic beta-cells and GABA has been suggested to play a role in islet cell development and function. Mouse beta-cells predominantly express the larger isoform of the e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d942dea9c74b00d93cbf5c31a1d2354c
https://pubmed.ncbi.nlm.nih.gov/10422732

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Akademický článek

Prophylactic Supplementation with Lactobacillus Reuteri or Its Metabolite GABA Protects Against Acute Ischemic Cardiac Injury.

Autor: Wang, Jiawan^1,2,3,4 (AUTHOR), Zhang, Hao^1,2,3,5 (AUTHOR), Yuan, Hailong^1,2,3,6 (AUTHOR), Chen, Siqi^1,2,3,5 (AUTHOR), Yu, Ying^5,7 (AUTHOR), Zhang, Xuan⁷ (AUTHOR), Gao, Zeyu^1,2,3 (AUTHOR), Du, Heng^1,2,3,5 (AUTHOR), Li, Weitao⁸ (AUTHOR), Wang, Yaohui⁶ (AUTHOR), Xia, Pengyan⁸ (AUTHOR), Wang, Jun^5,7 (AUTHOR) junwang@im.ac.cn, Song, Moshi^1,2,3,5 (AUTHOR) songmoshi@ioz.ac.cn

Publikováno v: Advanced Science. May2024, Vol. 11 Issue 18, p1-16. 16p.

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Immune reactivity of diabetes-associated human monoclonal autoantibodies defines multiple epitopes and detects two domain boundaries in glutamate decarboxylase

Autor: K, Syren, L, Lindsay, B, Stoehrer, K, Jury, F, Lühder, S, Baekkeskov, W, Richter

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 157(11)

Autoreactive islet cell Abs (ICA) accompany the pathogenic destruction of pancreatic beta cells in insulin-dependent diabetes mellitus (IDDM). Human monoclonal ICA (MICA 1-6), previously derived from a DR1/DR7-positive newly diagnosed diabetic patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::afc8c34321f1989fffe909470443ab16
https://pubmed.ncbi.nlm.nih.gov/8943434

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Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase

Autor: S, Baekkeskov, H J, Aanstoot, S, Christgau, A, Reetz, M, Solimena, M, Cascalho, F, Folli, H, Richter-Olesen, P, De Camilli, P D, Camilli

Publikováno v: Scopus-Elsevier
CIÊNCIAVITAE

The pancreatic islet beta-cell autoantigen of relative molecular mass 64,000 (64K), which is a major target of autoantibodies associated with the development of insulin-dependent diabetes mellitus (IDDM) has been identified as glutamic acid decarboxy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b909d3754176037f97304a8f507503a
https://pubmed.ncbi.nlm.nih.gov/1697648

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Cellular and subcellular localization of an Mr 64,000 protein autoantigen in insulin-dependent diabetes

Autor: M R, Christie, D G, Pipeleers, A, Lernmark, S, Baekkeskov

Publikováno v: The Journal of biological chemistry. 265(1)

Antibodies to an Mr 64,000 protein from human or rat islets have been detected at high frequency in newly diagnosed insulin-dependent diabetic patients. In this study, we show that the antigenic and amphiphilic properties of the rat islet Mr 64,000 p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f28024b86b0634544b7b13337478e592
https://pubmed.ncbi.nlm.nih.gov/2403561

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