Výsledky vyhledávání

Data from KRAS Mutation Status Is Associated with Enhanced Dependency on Folate Metabolism Pathways in Non–Small Cell Lung Cancer Cells

Autor: Sarah S. Bacus, David Sidransky, Keren Paz, Karen Pry, Patricia B. Trusk, Diarmuid M. Moran

KRAS gene mutation is linked to poor prognosis and resistance to therapeutics in non–small cell lung cancer (NSCLC). In this study, we have explored the possibility of exploiting inherent differences in KRAS-mutant cell metabolism for treatment. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6224b879257a08264438939e97acf6d
https://doi.org/10.1158/1535-7163.c.6536542.v1

Zobrazit plný text záznamu

Supplementary Table 2 from KRAS Mutation Status Is Associated with Enhanced Dependency on Folate Metabolism Pathways in Non–Small Cell Lung Cancer Cells

Autor: Sarah S. Bacus, David Sidransky, Keren Paz, Karen Pry, Patricia B. Trusk, Diarmuid M. Moran

PDF - 68K, Normalized basal gene expression microarray data for non-squamous NSCLC NCI60 cell lines were grouped according to KRAS mutation status. Genes showing significant differences in expression between KRAS mutant and KRAS wildtype cells were a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a52000bf10937f7e1bb188611ab2d0f9
https://doi.org/10.1158/1535-7163.22500685

Zobrazit plný text záznamu

Supplementary Table 1 from KRAS Mutation Status Is Associated with Enhanced Dependency on Folate Metabolism Pathways in Non–Small Cell Lung Cancer Cells

Autor: Sarah S. Bacus, David Sidransky, Keren Paz, Karen Pry, Patricia B. Trusk, Diarmuid M. Moran

PDF - 75K, Normalized basal gene expression microarray data for non-squamous NSCLC NCI60 cell lines were grouped according to KRAS mutation status. Genes showing significant differences in expression between KRAS mutant and KRAS wildtype cells were a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32970d1854abf60ef96c4f6544ff989a
https://doi.org/10.1158/1535-7163.22500688.v1

Zobrazit plný text záznamu

Supplementary Table 3 from KRAS Mutation Status Is Associated with Enhanced Dependency on Folate Metabolism Pathways in Non–Small Cell Lung Cancer Cells

Autor: Sarah S. Bacus, David Sidransky, Keren Paz, Karen Pry, Patricia B. Trusk, Diarmuid M. Moran

PDF - 69K, Normalized basal gene expression microarray data for non-squamous NSCLC NCI60 cell lines were grouped according to KRAS mutation status. Genes showing significant differences in expression between KRAS mutant and KRAS wildtype cells were a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::103fa5a94022bf8a7d1b9ac3883e907d
https://doi.org/10.1158/1535-7163.22500682.v1

Zobrazit plný text záznamu

Akademický článek

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Immune profiling reveals the diverse nature of the immune response in NSCLC and reveals signaling pathways that may influence the anti-tumor immune response

Autor: Christopher A. Hamm, Sarah S. Bacus, Karen Pry, Jim Lu

Publikováno v: Experimental and Molecular Pathology. 109:1-15

Recent FDA approvals of immunotherapy for NSCLC provide patients new treatment options, and these approvals also highlight the importance of the immune response in cancer treatment. While immunotherapy provides patients a new treatment option, the th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9d3cd18de1aa44d68d249e2035490c
https://doi.org/10.1016/j.yexmp.2019.04.004

Zobrazit plný text záznamu

Cytoplasmic Cyclin E Predicts Recurrence in Patients with Breast Cancer

Autor: Anna Biernacka, Min Yi, W. Fraser Symmans, Kwok-Leung Cheung, Cansu Karakas, Opoku Adjapong, Kim Anh Do, Gabriel N. Hortobagyi, Sarah S. Bacus, Khandan Keyomarsi, Kelly K. Hunt, Melissa L. Bondy, Ian O. Ellis, Min Jin Ha, Patricia A. Thompson, Aysegul A. Sahin

Publikováno v: Clinical Cancer Research. 23:2991-3002

Purpose: Low molecular weight cyclin E (LMW-E) detected by Western blot analysis predicts for reduced breast cancer survival; however, it is impractical for clinical use. LMW-E lacks a nuclear localization signal that leads to accumulation in the cyt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65115c97ea2d94d2d8fb69e93e815a10
https://doi.org/10.1158/1078-0432.ccr-16-2217

Zobrazit plný text záznamu

Genomic and Immunological Tumor Profiling Identifies Targetable Pathways and Extensive CD8+/PDL1+ Immune Infiltration in Inflammatory Breast Cancer Tumors

Autor: Sarah S. Bacus, Diarmuid Moran, Massimo Cristofanilli, Siân Jones, Christopher A. Hamm, Victor E. Velculescu, Karen Pry, Patricia Trusk, Mark Sausen, Kakuturu Rao

Publikováno v: Molecular Cancer Therapeutics. 15:1746-1756

Inflammatory breast cancer (IBC) is a rare and aggressive form of breast cancer that remains poorly understood at the molecular level. Comprehensive tumor profiling was performed to understand clinically actionable alterations in IBC. Targeted next-g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e72137e26cc9b2239513c2d83ec8995d
https://doi.org/10.1158/1535-7163.mct-15-0353

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání