Zobrazeno 1 - 10
of 46
pro vyhledávání: '"S B Jennifer, Kan"'
Autor:
Xiongyi Huang, Marc Garcia-Borràs, Kun Miao, S. B. Jennifer Kan, Arjun Zutshi, K. N. Houk, Frances H. Arnold
Publikováno v:
ACS Central Science, Vol 5, Iss 2, Pp 270-276 (2019)
Externí odkaz:
https://doaj.org/article/c2703708240b40c69c39afc944cfe743
Autor:
Anders M. Knight, S. B. Jennifer Kan, Russell D. Lewis, Oliver F. Brandenberg, Kai Chen, Frances H. Arnold
Publikováno v:
ACS Central Science, Vol 4, Iss 3, Pp 372-377 (2018)
Externí odkaz:
https://doaj.org/article/57854300ada54c8faf11446f3e61e4a8
Autor:
Frances H. Arnold, Russell D. Lewis, Gonzalo Jiménez-Osés, Allison Tang, Marc Garcia-Borràs, Kendall N. Houk, S. B. Jennifer Kan
A cytochrome c heme protein was recently engineered to catalyze the formation of carbon–silicon bonds via carbene insertion into Si–H bonds, a reaction that was not previously known to be catalyzed by a protein. High chemoselectivity towards C–
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359b3fc9b9f22ba295739a4a37f47d77
https://resolver.caltech.edu/CaltechAUTHORS:20210429-132053494
https://resolver.caltech.edu/CaltechAUTHORS:20210429-132053494
Autor:
Marc, Garcia-Borràs, S B Jennifer, Kan, Russell D, Lewis, Allison, Tang, Gonzalo, Jimenez-Osés, Frances H, Arnold, K N, Houk
Publikováno v:
J Am Chem Soc
A cytochrome c heme protein was recently engineered to catalyze the formation of carbon–silicon bonds via carbene insertion into Si–H bonds, a reaction that was not previously known to be catalyzed by a protein. High chemoselectivity toward C–S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::41e7f99ab54ddab2f5b71d6871079659
https://pubmed.ncbi.nlm.nih.gov/33909977
https://pubmed.ncbi.nlm.nih.gov/33909977
Autor:
Frances H. Arnold, Bruce J. Wittmann, Julie L. Hofstra, Anders M. Knight, S. B. Jennifer Kan, Sarah E. Reisman
Publikováno v:
ACS Catal
While biocatalysis is increasingly incorporated into drug development pipelines, it is less commonly used in the early stages of drug discovery. By engineering a protein to produce a chiral motif with a derivatizable functional handle, biocatalysts c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d341980e44cfb5658215331dc69448c
https://resolver.caltech.edu/CaltechAUTHORS:20200608-115355402
https://resolver.caltech.edu/CaltechAUTHORS:20200608-115355402
Publikováno v:
Nature. 552:132-136
Recent advances in enzyme engineering and design have expanded nature’s catalytic repertoire to functions that are new to biology. However, only a subset of these engineered enzymes can function in living systems. Finding enzymatic pathways that fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc2b45dd0718a6871e480ef10a2deaaf
https://doi.org/10.1038/nature24996
https://doi.org/10.1038/nature24996
Publikováno v:
ACS Catal
On the occasion of Professor Frances H. Arnold’s recent acceptance of the 2018 Nobel Prize in Chemistry, we honor her numerous contributions to the fields of directed evolution and biocatalysis. Arnold pioneered the development of directed evolutio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b176d9e3f7c5197ef3bc970fd8226fd1
https://resolver.caltech.edu/CaltechAUTHORS:20190917-160539760
https://resolver.caltech.edu/CaltechAUTHORS:20190917-160539760
To reduce experimental effort associated with directed protein evolution and to explore the sequence space encoded by mutating multiple positions simultaneously, we incorporate machine learning in the directed evolution workflow. Combinatorial sequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37c4c89af26b501ad4fce537258d7e34
http://arxiv.org/abs/1902.07231
http://arxiv.org/abs/1902.07231
Autor:
Arjun Zutshi, S. B. Jennifer Kan, Xiongyi Huang, Marc Garcia-Borràs, Frances H. Arnold, Kun Miao, K. N. Houk
Publikováno v:
ACS central science, vol 5, iss 2
ACS Central Science
ACS Central Science, Vol 5, Iss 2, Pp 270-276 (2019)
ACS Central Science
ACS Central Science, Vol 5, Iss 2, Pp 270-276 (2019)
There are few biocatalytic transformations that produce fluorine-containing molecules prevalent in modern pharmaceuticals. To expand the scope of biocatalysis for organofluorine synthesis, we have developed an enzymatic platform for highly enantiosel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b35efe7d114aa3dde118011e92ce879b
https://escholarship.org/uc/item/46p8g5b3
https://escholarship.org/uc/item/46p8g5b3
Autor:
Xin Hong, Kai Chen, Xiongyi Huang, S. B. Jennifer Kan, Shuo-Qing Zhang, Andrew Z. Zhou, Frances H. Arnold
Previous work has demonstrated that variants of a heme protein, Rhodothermus marinus cytochrome c (Rma cyt c), catalyze abiological carbene boron–hydrogen (B–H) bond insertion with high efficiency and selectivity. Here we investigated this carbon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cab0982065d30d26a250308c4c22fe57
https://europepmc.org/articles/PMC6436545/
https://europepmc.org/articles/PMC6436545/