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Autor:
Jian Wang, Donna M. Barten, J Lubinski, R Krishna, J J Anderson, K M Felsenstein, S B Hansel, A Thakur, D W Boulton, K S Santone, Ming Yao, Ming Zheng, J M Pursley, Oliver P. Flint
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 39(7)
BMS-299897 is a gamma-secretase inhibitor that was effective in reducing amyloid beta-peptide (A beta) in transgenic mice and guinea pigs. Therefore, pharmacokinetic and drug metabolism studies were conducted in animals to support its clinical develo