Výsledky vyhledávání - "S B Abramson"

Interferon pathway lupus risk alleles modulate risk of death from acute COVID-19

Autor: M. Attur, C. M. Petrilli, Ruth Fernandez-Ruiz, S. B. Abramson, Timothy B. Niewold, Jacqueline L. Paredes, Ashira D Blazer, A. Chakravarti, E. Iturrate, T. L. Wampler Muskardin, S. Tuminello, I. Nln

Publikováno v: medRxiv
article-version (status) pre
article-version (number) 1
Translational Research

Type I interferon (IFN) is critical in our defense against viral infections. Increased type I IFN pathway activation is a genetic risk factor for systemic lupus erythematosus (SLE), and a number of common risk alleles contribute to the high IFN trait

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c49b16c59379d00d89caa7644fc970aa
https://doi.org/10.1101/2021.11.01.21265766

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Joint efforts: tackling arthritis using gene therapy

Autor: S. B. Abramson, Paul D. Robbins, Christopher H. Evans, J. J. Rediske

Publikováno v: Molecular Medicine Today. 5:148-151

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bc4726c4984dcae8ea22f9b57c4304a1
https://doi.org/10.1016/s1357-4310(99)01452-5

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Neutrophil adherence to endothelium is enhanced via adenosine A1 receptors and inhibited via adenosine A2 receptors

Autor: B N Cronstein, R I Levin, M Philips, R Hirschhorn, S B Abramson, G Weissmann

Publikováno v: The Journal of Immunology. 148:2201-2206

We have recently demonstrated that human neutrophils (PMN) possess two different classes of adenosine receptors (A1 and A2) that, when occupied, promote chemotaxis and inhibit the generation of reactive oxygen species (e.g., O2- and H2O2), respective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ca4a491a5441394a19bae6484266096
https://doi.org/10.4049/jimmunol.148.7.2201

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Arachidonic acid as a second messenger. Interactions with a GTP-binding protein of human neutrophils

Autor: S B Abramson, J Leszczynska-Piziak, G Weissmann

Publikováno v: The Journal of Immunology. 147:231-236

Arachidonic acid (20:4) and other cis-unsaturated fatty acids exert direct effects on a variety of cells, effects that do not depend on the metabolism of fatty acids via cyclooxygenase or lipoxygenase pathways. In these studies arachidonic acid and o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::40bb11446304622edafb0c594351670d
https://doi.org/10.4049/jimmunol.147.1.231

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Cocaine and its derivatives blunt neutrophil functions without influencing phosphorylation of a 47-kilodalton component of the reduced nicotinamide-adenine dinucleotide phosphate oxidase

Autor: K A Haines, J Reibman, P E Callegari, S B Abramson, M R Philips, G Weissmann

Publikováno v: The Journal of Immunology. 144:4757-4764

Cocaine and its derivatives blunted responses of neutrophils (cell/cell aggregation, up-regulation of the receptor for C3bi (CR3, CD11b/CD18), generation of superoxide anion (O2-) and degranulation to various stimuli. The order of potency of these ag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9c00a44ba125e2292c176f3c99caa2a
https://doi.org/10.4049/jimmunol.144.12.4757

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Constitutive and induced phosphorylation of the alpha- and beta-chains of the CD11/CD18 leukocyte integrin family. Relationship to adhesion-dependent functions

Autor: J P Buyon, S G Slade, J Reibman, S B Abramson, M R Philips, G Weissmann, R Winchester

Publikováno v: The Journal of Immunology. 144:191-197

We sought to determine whether the activation event which renders the CD11/CD18 leukocyte integrin/Leu-CAM glycoproteins capable of promoting cell to cell adhesion was associated with the induced posttranslational modification of phosphorylation. In

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::10225b49994dac10f3ac4e8599d0b93e
https://doi.org/10.4049/jimmunol.144.1.191

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Overview of benefit/risk of biological agents

Autor: A K, Imperato, C O, Bingham, S B, Abramson

Publikováno v: Clinical and experimental rheumatology. 22(5 Suppl 35)

Targeted tumor necrosis factor-alpha antagonists, first approved by the FDA in 1998, have had a significant impact on the treatment of patients with rheumatoid arthritis. In general, the benefit/ risk ratio for these agents and the IL-1 receptor anta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1431a958c32a553a6a253dd6f8c85a1c
https://pubmed.ncbi.nlm.nih.gov/15552523

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'A system biology' approach to bioinformatics and functional genomics in complex human diseases: arthritis

Autor: M G, Attur, M N, Dave, K, Tsunoyama, M, Akamatsu, M, Kobori, J, Miki, S B, Abramson, M, Katoh, A R, Amin

Publikováno v: Current issues in molecular biology. 4(4)

Human and other annotated genome sequences have facilitated generation of vast amounts of correlative data, from human/animal genetics, normal and disease-affected tissues from complex diseases such as arthritis using gene/protein chips and SNP analy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dbb8c90aada41480e91582575626eb79
https://pubmed.ncbi.nlm.nih.gov/12432964

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