Výsledky vyhledávání - "S B, Svetlikova"

Histone Deacetylase HDAC6 Inhibitor CAY10603 Blocks G1/S of the Cell Cycle and Promotes Senescence of Murine Fibroblasts Transformed with E1A and cHa-ras Oncogenes

Autor: S. B. Svetlikova, Kukushkin An

Publikováno v: Cell and Tissue Biology. 13:268-275

CAY10603 (CAY) is an effective inhibitor of HDAC6 histone deacetylase involved in α-tubulin deacetylation for murine fibroblasts transformed with E1A and cHa-ras oncogenes. In low concentrations, CAY blocks the cell cycle of the G1/S phase of these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::124b71b4bccd8a0917c68f1717ca7475
https://doi.org/10.1134/s1990519x19040047

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p21Waf1 deficiency does not decrease DNA repair in E1A+cHa-Ras transformed cells by HDI sodium butyrate

Autor: Valery A. Pospelov, M. V. Igotti, S. B. Svetlikova, Olga Gnedina, Alisa Morshneva

Publikováno v: Biological Chemistry. 399:1297-1304

This study aimed to explore a role of p21Waf1 in γH2AX foci formation and DNA repair as assessed by a Host-Cell Reactivation Assay in wild-type (p21Waf+/+) and p21Waf1-deficient E1A+Ras-transformed cells. p21Waf1+/+ cells have low γH2AX background

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c43cb2c2032094ade3a4a46c7e0db4f1
https://doi.org/10.1515/hsz-2018-0249

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Time-dependent modulation of FoxO activity by HDAC inhibitor in oncogene-transformed E1A+Ras cells

Autor: Valery A. Pospelov, Olga Gnedina, S. B. Svetlikova, Alisa Morshneva, M. V. Igotti

Publikováno v: AIMS Genetics
AIMS Genetics, Vol 5, Iss 1, Pp 41-52 (2018)

HDAC inhibitors (HDACIs) induce irreversible cell cycle arrest and senescence in mouse embryonic fibroblasts transformed with E1A and c-Ha-Ras oncogenes (E1A+Ras cell line). The aging rate has been associated with the production of high levels of Rea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a96de180312f0a11ce8d8ad2430bd4cc
http://europepmc.org/articles/PMC6690250

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The effects of the HDAC inhibitor sodium butyrate on the expression of repair genes Rad51 and XRCC5 in fibroblast lines mEras-Waf1+/+ and mEras-Waf1–/–

Autor: Kukushkin An, S. B. Svetlikova, Valery A. Pospelov

Publikováno v: Cell and Tissue Biology. 11:133-140

Transformed mice fibroblasts with a knockout CDKN1A gene, which encodes р21/Waf1 protein (mEras-Waf1–/–cells), are characterized by a large number of single-strand DNA breaks and associated γ-H2A.X foci compared to the initial transformant line

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eece03271ce5a1a5819bc2a46de2b06e
https://doi.org/10.1134/s1990519x1702002x

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Overexpression of Adenoviral E1A Sensitizes E1A+Ras-Transformed Cells to the Action of Histone Deacetylase Inhibitors

Autor: Valery A. Pospelov, S. B. Svetlikova, M. V. Igotti

Publikováno v: Acta Naturae

The adenoviral E1A protein induces cell proliferation, transformation, and tumor formation in rodents, on the one hand. On the other hand, E1A expression increases cell sensitivity to a number of cytotoxic agents. Therefore, E1A is a candidate for us

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97858a669ad4d177de343127741a8012
https://pubmed.ncbi.nlm.nih.gov/30713764

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Sodium butyrate enhances the antiproliferative action of low actinomycin D concentrations

Autor: E. A. Filippova, Valery A. Pospelov, S. B. Svetlikova, O. O. Gnedina, M. V. Igotti

Publikováno v: Cell and Tissue Biology. 11:42-50

Histone deacetylase inhibitors (HDIs) cause an irreversible cell cycle arrest in G1 phase and senescence of E1A + Ras transformed fibroblasts. The modulation of the antiproliferative action of the RNA synthesis inhibitor actinomycin D (AMD) with sodi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36afbd6034e09ead7a6455240f42f78c
https://doi.org/10.1134/s1990519x17010059

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SODIUM BUTYRATE ENHANCES THE ANTIPROLIFERATIVE EFFECT OF HIGH CONCENTRATIONS OF ACTINOMYCIN D

Autor: M V, Igotti, O O, Gnedina, S B, Svetlikova, E A, Filippova, V A, ospelov

Publikováno v: Tsitologiia. 58(10)

In the present article we have studied the combined effect of actinomycin D (AMD) with HDI sodium butyrate (NaBut) on proliferation of transformed cells. It has been shown that NaBut increased the cytotoxic effect of low concentrations of AMD (8 nM).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0764463132fa636149d466a86bca2751
https://pubmed.ncbi.nlm.nih.gov/30198696

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INFLUENCE OF HDAC INHIBITOR SODIUM BUTYRATE ON THE EXPRESSION OF DNA REPAIR GENES Rad51 AND XRCC5 IN mEras-Waf1+/+ AND mEras-Waf1–/–

Autor: A N, Kukushkin, S B, Svetlikova, V A, Pospelov

Publikováno v: Tsitologiia. 58(12)

Mouse embryonal fibroblasts with knockout of CDKN1A gene encoding p21/Waf1 protein transformed by oncogenes E1A and cHa-ras (mEras-Waf1–/– cell line) have been used to assess the level of DNA repair genes expression — Rad51 and XRCC5 after trea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fb1634fcc4709d45e0e6340e66fe1668
https://pubmed.ncbi.nlm.nih.gov/30188106

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