Zobrazeno 1 - 10 of 93 pro vyhledávání: '"S B, Prusiner"'
1
Prions
Autor: D. W. Colby, S. B. Prusiner
Publikováno v: Cold Spring Harbor perspectives in biology. 3(1)
The discovery of infectious proteins, denoted prions, was unexpected. After much debate over the chemical basis of heredity, resolution of this issue began with the discovery that DNA, not protein, from pneumococcus was capable of genetically transfo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e056d195bc4537fc3834b1673e2478f
https://pubmed.ncbi.nlm.nih.gov/21421910
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2
Engineering the prion protein using chemical synthesis
Autor: H L, Ball, D S, King, F E, Cohen, S B, Prusiner, M A, Baldwin
Publikováno v: The journal of peptide research : official journal of the American Peptide Society. 58(5)
In recent years, the technology of solid-phase peptide synthesis (SPPS) has improved to the extent that chemical synthesis of small proteins may be a viable complementary strategy to recombinant expression. We have prepared several modified and wild-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cf7309db4df1ac67e56ea411b0f9160c
https://pubmed.ncbi.nlm.nih.gov/11892845
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4
Quantitative traits of prion strains are enciphered in the conformation of the prion protein
Autor: J, Safar, F E, Cohen, S B, Prusiner
Publikováno v: Archives of virology. Supplementum. (16)
Variations in prions, which cause different disease phenotypes, are often referred to as strains. Strains replicate with a high degree of fidelity, which demands a mechanism that can account for this phenomenon. Prion strains differ by qualitative ch
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0876c6b03d81a496c2dd9fe36142e9d6
https://pubmed.ncbi.nlm.nih.gov/11214926
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5
Transgenic models of prion disease
Autor: M R, Scott, S, Supattapone, H O, Nguyen, S J, DeArmond, S B, Prusiner
Publikováno v: Archives of virology. Supplementum. (16)
There is growing concern that bovine spongiform encephalopathy (BSE) may have passed from cattle to humans, resulting in approximately 70 cases of an atypical, variant CJD (vCJD) in teenagers and young adults. We report here that transgenic (Tg) mice
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0d1237087dd7a29aca9c1ba88224e281
https://pubmed.ncbi.nlm.nih.gov/11214913
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7
Selective neuronal vulnerability during experimental scrapie infection: insights from an ultrastructural investigation
Autor: E, Bouzamondo, A M, Milroy, H J, Ralston, S B, Prusiner, S J, DeArmond
Publikováno v: Brain research. 874(2)
The goal was to test whether all neurons are equally susceptible to degeneration in response to PrP(Sc) scrapie infection. We tested this by immunogold GABA labeling. Our ultrastructural results indicates that GABAergic neurons are less vulnerable th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6474a0ddf9665e4810962508ae5ae781
https://pubmed.ncbi.nlm.nih.gov/10960606
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8
Structural changes in a hydrophobic domain of the prion protein induced by hydration and by ala--Val and pro--Leu substitutions
Autor: H, Inouye, J, Bond, M A, Baldwin, H L, Ball, S B, Prusiner, D A, Kirschner
Publikováno v: Journal of molecular biology. 300(5)
X-ray diffraction was used to study the structure of assemblies formed by synthetic peptide fragments of the prion protein (PrP) that include the hydrophobic domain implicated in the Gerstmann-Sträussler-Scheinker (GSS) mutation (P102L). The effects
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2805812526af11b83ebac0bd6762b87b
https://pubmed.ncbi.nlm.nih.gov/10903869
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9
Doppel is an N-glycosylated, glycosylphosphatidylinositol-anchored protein. Expression in testis and ectopic production in the brains of Prnp(0/0) mice predisposed to Purkinje cell loss
Autor: G L, Silverman, K, Qin, R C, Moore, Y, Yang, P, Mastrangelo, P, Tremblay, S B, Prusiner, F E, Cohen, D, Westaway
Publikováno v: The Journal of biological chemistry. 275(35)
The Prnd gene encodes a homolog of the cellular prion protein (PrP(C)) called doppel (Dpl). Up-regulation of Prnd mRNA in two distinct lines of PrP gene ablated (Prnp(0/0)) mice, designated Rcm0 and Ngsk, is associated with death of Purkinje cells. U
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7bffb3ab17b6ff748ffb60b457360f2b
https://pubmed.ncbi.nlm.nih.gov/10842180
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10
Antibody binding defines a structure for an epitope that participates in the PrPC--PrPSc conformational change
Autor: Z F, Kanyo, K M, Pan, R A, Williamson, D R, Burton, S B, Prusiner, R J, Fletterick, F E, Cohen
Publikováno v: Journal of molecular biology. 293(4)
The X-ray crystallographic structures of the anti-Syrian hamster prion protein (SHaPrP) monoclonal Fab 3F4 alone, as well as the complex with its cognate peptide epitope (SHaPrP 104-113), have been determined to atomic resolution. The conformation of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e55a256d8dfd0d05d6ca8bebf593915e
https://pubmed.ncbi.nlm.nih.gov/10543972
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