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Akademický článek

Interoperable and explainable machine learning models to predict morbidity and mortality in acute neurological injury in the pediatric intensive care unit: secondary analysis of the TOPICC study

Autor: Neil K. Munjal, Robert S. B. Clark, Dennis W. Simon, Patrick M. Kochanek, Christopher M. Horvat

Publikováno v: Frontiers in Pediatrics, Vol 11 (2023)

BackgroundAcute neurological injury is a leading cause of permanent disability and death in the pediatric intensive care unit (PICU). No predictive model has been validated for critically ill children with acute neurological injury.ObjectivesWe hypot

Externí odkaz: https://doaj.org/article/58bb97b6d4d445e790b37217efd39147

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Akademický článek

Personalising Outcomes after Child Cardiac Arrest (POCCA): design and recruitment challenges of a multicentre, observational study

Autor: Elizabeth Hunt, Katie Smith, Neha Patel, Ericka L Fink, Robert S B Clark, Ashok Panigrahy, Rachel Berger, Jessica Wisnowski, Stefan Bluml, David Maloney, Pamela Rubin, Tamara Haller, Hulya Bayir, Sue R Beers, Patrick M Kochanek, Anthony Fabio, Patrick Kochanek, Robert Clark, Sue Beers, Tony Fabio, Karen Walson, Alexis Topjian, Christopher JL Newth, Jordan Duval-Arnould, Binod Balakrishnan, Michael T Meyer, Melissa G Chung, Anthony Willyerd, Lincoln Smith, Jesse Wenger, Stuart Friess, Jose Pineda, Ashley Siems, Jason Patregnani, John Diddle, Aline Maddux, Lesley Doughty, Juan Piantino, Beena Desai, Maureen G Richardson, Cynthia Bates, Darshana Parikh, Janice Prodell, Maddie Winters, Jeni Kwok, Adriana Cabrales, Ronke Adewale, Pam Melvin, Sadaf Shad, Katherine Siegel, Katherine Murkowski, Mary Kasch, Josey Hensley, Lisa Steele, Danielle Brown, Brian Burrows, Lauren Hlivka, Deana Rich, Amila Tutundzic, Tina Day, Lori Barganier, Ashley Wolfe, Mackenzie Little, Elyse Tomanio, Diane Hession, Yamila Sierra, Ruth Grosskreuz, BS Kevin Van, Rhonda Jones, Laura Benken, Beata Dyar, Laura Mishler, Jonathan Elmer, Subramanian Subramanian, Julia Wallace, Tami Robinson, Andrew Frank, Keri Feldman, Avinash Vemulapalli, Linda Ryan, Scott Szypulski, Christopher Keys

Publikováno v: BMJ Open, Vol 10, Iss 10 (2020)

Introduction Blood and imaging biomarkers show promise in prognosticating outcomes after paediatric cardiac arrest in pilot studies. We describe the methods and early recruitment challenges and solutions for an ongoing multicentre (n=14) observationa

Externí odkaz: https://doaj.org/article/34a73484274645ee9fcef00252b04fe2

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Clinical translation of noninvasive intracranial pressure sensing with diffuse correlation spectroscopy

Autor: Syeda Tabassum, Alexander Ruesch, Deepshikha Acharya, Jason Yang, Filip A. J. Relander, Bradley Scammon, Michael S. Wolf, Jaskaran Rakkar, Robert S. B. Clark, Michael M. McDowell, Jana M. Kainerstorfer

Publikováno v: Journal of Neurosurgery. :1-10

OBJECTIVE Intracranial pressure (ICP) is an important therapeutic target in many critical neuropathologies. The current tools for ICP measurements are invasive; hence, these are only selectively applied in critical cases where the benefits surpass th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5863a6a1aff63660664357a5bfe7fddb
https://doi.org/10.3171/2022.9.jns221203

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Temporal Patterns in Brain Tissue and Systemic Oxygenation Associated with Mortality After Severe Traumatic Brain Injury in Children

Autor: Jaskaran Rakkar, Justin Azar, Jonathan H. Pelletier, Alicia K. Au, Michael J. Bell, Dennis W. Simon, Patrick M. Kochanek, Robert S. B. Clark, Christopher M. Horvat

Publikováno v: Neurocritical Care. 38:71-84

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0cfd38413634b93e7bb66ed4e0de1629
https://doi.org/10.1007/s12028-022-01602-3

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Akademický článek

Effect of dietary cellulose supplementation on gut barrier function and apoptosis in a murine model of endotoxemia.

Autor: Valentina Di Caro, Alicia M Alcamo, Jessica L Cummings, Robert S B Clark, Elizabeth A Novak, Kevin P Mollen, Michael J Morowitz, Rajesh K Aneja

Publikováno v: PLoS ONE, Vol 14, Iss 12, p e0224838 (2019)

The gut plays a vital role in critical illness, and alterations in the gut structure and function have been reported in endotoxemia and sepsis models. Previously, we have demonstrated a novel link between the diet-induced alteration of the gut microb

Externí odkaz: https://doaj.org/article/aa8637f50f0040c2815ddbc131dcb840

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