Výsledky vyhledávání - "S B, Bratton"

Caspase cascades in chemically-induced apoptosis

Autor: S B, Bratton, G M, Cohen

Publikováno v: Advances in experimental medicine and biology. 500

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0703ddbdc1e0d7cc2f9c221718c82da6
https://pubmed.ncbi.nlm.nih.gov/11764974

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Caspase-3 cleaves Apaf-1 into an approximately 30 kDa fragment that associates with an inappropriately oligomerized and biologically inactive approximately 1.4 MDa apoptosome complex

Autor: S B, Bratton, G, Walker, D L, Roberts, K, Cain, G M, Cohen

Publikováno v: Cell death and differentiation. 8(4)

Cytochrome c and dATP/ATP induce oligomerization of Apaf-1 into two distinct apoptosome complexes: an approximately 700 kDa complex, which recruits and activates caspases-9, -3 and -7, and an approximately 1.4 MDa complex, which recruits and processe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4df9060563fe86e986977e89deddcd55
https://pubmed.ncbi.nlm.nih.gov/11550094

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Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes

Autor: K, Cain, S B, Bratton, C, Langlais, G, Walker, D G, Brown, X M, Sun, G M, Cohen

Publikováno v: The Journal of biological chemistry. 275(9)

Apaf-1, by binding to and activating caspase-9, plays a critical role in apoptosis. Oligomerization of Apaf-1, in the presence of dATP and cytochrome c, is required for the activation of caspase-9 and produces a caspase activating apoptosome complex.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8c26f3bdc189b2c3cd18d77aff0f602f
https://pubmed.ncbi.nlm.nih.gov/10692394

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