Zobrazeno 1 - 10
of 20
pro vyhledávání: '"S B, Blunt"'
Publikováno v:
European Journal of Neuroscience. 10:57-63
Glial cell-line-derived neurotrophic factor (GDNF) has been shown to enhance the survival of dopaminergic neurones both in vitro and in vivo, and to protect the rodent dopaminergic system from neurotoxic damage. However, most previous studies have on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99615fe484e84f39b432b0d1a624024e
https://doi.org/10.1046/j.1460-9568.1998.00016.x
https://doi.org/10.1046/j.1460-9568.1998.00016.x
Publikováno v:
Movement Disorders. 12:235-238
Two patients are described with clinical and neuroimaging features consistent with a diagnosis of multiple system atrophy (MSA). The patients are unusual in that facial myokymia became apparent clinically at some stage in their illness. In each patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d311105c9677a5f7ea38ad9b37a27c8
https://doi.org/10.1002/mds.870120215
https://doi.org/10.1002/mds.870120215
Publikováno v:
Brain Research. 592:129-134
The implantation of dopamine-rich mesencephalic grafts into the 6-hydroxydopamine (6-OHDA)-lesioned neostriatum of rats was accompanied by marked hyperinnervation by serotonin (5-HT) fibers. The purpose of this study was to examine the possibility th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb9d52d8da5e72411b15c77ee97a8ccb
https://doi.org/10.1016/0006-8993(92)91667-4
https://doi.org/10.1016/0006-8993(92)91667-4
Publikováno v:
Brain Research. 562:301-305
The effects of 6-hydroxydopamine lesions of the nigrostriatal pathway on striatal serotonin (5-HT) innervation have been examined using immunohistochemistry in adult rats. One day after lesioning, a large number of swollen and densely stained 5-HT-im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98f172a50ddb3634769fad3344beecef
https://doi.org/10.1016/0006-8993(91)90635-9
https://doi.org/10.1016/0006-8993(91)90635-9
Publikováno v:
Brain Research. 551:171-177
The sprouting of serotonergic fibers into the neostriatum of 6-OHDA-lesioned rats should be considered, when assessing the functional aspects of ventral mesencephalic grafts. The degree of serotonergic fiber growth into the neostriatum of rats subjec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac89b2dbf1d973f46e00b6fd1beeb946
https://doi.org/10.1016/0006-8993(91)90930-t
https://doi.org/10.1016/0006-8993(91)90930-t
Autor:
S. B. Blunt
Publikováno v:
Clinical Trials in Neurology ISBN: 9781849968560
There has been a huge amount of research into neurodegenerative diseases in the past 30 years. In Parkinson’s disease, the research has been fruitful, demonstrating amongst many other findings that the main biochemical abnormality in the brain is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0c92ecc7e90a40ab5f78f2394be7129
https://doi.org/10.1007/978-1-4471-3787-0_26
https://doi.org/10.1007/978-1-4471-3787-0_26
Publikováno v:
The European journal of neuroscience. 10(12)
Growth/differentiation factor 5 is a member of the transforming growth factor beta superfamily, which has neurotrophic and neuroprotective effects on dopaminergic neurons both in vitro and in vivo. Here we investigate the effects of growth/differenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4bb881322b511923ae91ccdae537bcda
https://pubmed.ncbi.nlm.nih.gov/9875347
https://pubmed.ncbi.nlm.nih.gov/9875347
Publikováno v:
Journal of neural transmission (Vienna, Austria : 1996). 103(12)
The lesion caused by a single 6-hydroxydopamine injection into rat striatum was evaluated. In vivo positron emission tomography using a dopamine reuptake tracer revealed no consistent reduction in striatal dopamine transporter. Amphetamine rotation t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d3227fd90516bf9f124635b0e973066a
https://pubmed.ncbi.nlm.nih.gov/9029409
https://pubmed.ncbi.nlm.nih.gov/9029409
Publikováno v:
Neuroreport. 7(1)
We have investigated whether glial cell line-derived neurotrophic factor (GDNF) protects against a complete unilateral 6-hydroxydopamine (6-OHDA) nigrostriatal lesion, a robust rat model of Parkinson's disease. GDNF or vehicle were administered above
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::522051053367bbf92d418ab1328aac85
https://pubmed.ncbi.nlm.nih.gov/8742486
https://pubmed.ncbi.nlm.nih.gov/8742486
Publikováno v:
Movement disorders : official journal of the Movement Disorder Society. 8(2)
Ever since the introduction of levo-3, 4-dihydroxyphenylalanine (L-dopa) for the treatment of Parkinson's disease, there has been concern that it might accelerate the degeneration of dopamine neurones. Using rats with a unilateral 6-hydroxydopamine (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8718e263d6c419bb6bd0449a96724f8
https://pubmed.ncbi.nlm.nih.gov/8097279
https://pubmed.ncbi.nlm.nih.gov/8097279