Uncovering Key Metabolic Determinants of the Drug Interactions Between Trimethoprim and Erythromycin in Escherichia coli

Autor: Qin Qi, S. Andreas Angermayr, Tobias Bollenbach

Publikováno v: Frontiers in Microbiology, Vol 12 (2021)

Understanding interactions between antibiotics used in combination is an important theme in microbiology. Using the interactions between the antifolate drug trimethoprim and the ribosome-targeting antibiotic erythromycin in Escherichia coli as a mode

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doajarticles::8546f5acdda9a96ff5cd9b81609edcfb
https://www.frontiersin.org/articles/10.3389/fmicb.2021.760017/full

Nonhierarchical Flux Regulation Exposes the Fitness Burden Associated with Lactate Production in Synechocystis sp. PCC6803

Autor: Klaas J. Hellingwerf, S. Andreas Angermayr, Wei Du, Filipe Branco dos Santos, Joeri A. Jongbloets, Herwig Bachmann, Douwe Molenaar

Publikováno v: Du, W, Angermayr, S A, Jongbloets, J A, Molenaar, D, Bachmann, H, Hellingwerf, K J & Santos, F 2016, ' Non-hierarchical flux regulation exposes the fitness burden associated with lactate production in Synechocystis sp PCC6803. ', ACS synthetic biology, vol. 2016/12/12 . https://doi.org/10.1021/acssynbio.6b00235
ACS Synthetic Biology, 6(3), 395-401. American Chemical Society
ACS synthetic biology, 2016/12/12. American Chemical Society

Cyanobacteria are mostly engineered to be sustainable cell-factories by genetic manipulations alone. Here, by modulating the concentration of allosteric effectors, we focus on increasing product formation without further burdening the cells with incr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c9549c2530322f1ff8e691b7ecda558
https://doi.org/10.1021/acssynbio.6b00235

Chirality Matters: Synthesis and Consumption of the d-Enantiomer of Lactic Acid by Synechocystis sp. Strain PCC6803

Autor: S. Andreas Angermayr, Ramona Kern, Klaas J. Hellingwerf, Danilo Correddu, Aniek D. van der Woude, Martin Hagemann

Publikováno v: Applied and Environmental Microbiology, 82(4), 1295-1304. American Society for Microbiology

Both enantiomers of lactic acid, l -lactic acid and d -lactic acid, can be produced in a sustainable way by a photosynthetic microbial cell factory and thus from CO 2 , sunlight, and water. Several properties of polylactic acid (a polyester of polyme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7fd47ccea7fec05ab5c72256835c9fb
https://hdl.handle.net/11245/1.524125

Synthesis of 2,3-butanediol by Synechocystis sp. PCC6803 via heterologous expression of a catabolic pathway from lactic acid- and enterobacteria

Autor: Klaas J. Hellingwerf, S. Andreas Angermayr, Philipp Savakis

Publikováno v: Metabolic Engineering, 20, 121-130. Academic Press Inc.

The direct and efficient conversion of CO2 into liquid energy carriers and/or bulk chemicals is crucial for a sustainable future of modern society. Here we describe the production of 2,3-butanediol in Synechocystis sp. PCC6803 expressing a heterologo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb8e725fd49d087661b91cca78fa821
https://doi.org/10.1016/j.ymben.2013.09.008

Engineering a cyanobacterial cell factory for production of lactic acid

Autor: Klaas J. Hellingwerf, S. Andreas Angermayr, Michal Paszota

Publikováno v: Applied and Environmental Microbiology, 78(19), 7098-7106. American Society for Microbiology

Metabolic engineering of microorganisms has become a versatile tool to facilitate production of bulk chemicals, fuels, etc. Accordingly, CO 2 has been exploited via cyanobacterial metabolism as a sustainable carbon source of biofuel and bioplastic pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099799b06fa3b4d5451630304d119db2
https://doi.org/10.1128/aem.01587-12