Výsledky vyhledávání - "S Amanda, Ali"

Supplementary Figure Legends from Hedgehog Pathway Inhibition in Chondrosarcoma Using the Smoothened Inhibitor IPI-926 Directly Inhibits Sarcoma Cell Growth

Autor: Jay S. Wunder, Benjamin A. Alman, Karen McGovern, Suneel S. Apte, Lauren W. Wang, Jennifer Proctor, John Keilty, Qingxia Wei, Raymond Poon, Heather Whetstone, Chang Ye Yale Wang, S. Amanda Ali, Puviindran Nadesan, Veronica T. Campbell

PDF - 62K, Legends for Supplementary Figures 1 and 2.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0031bc8b77d1f2a721eb5f234c31d844
https://doi.org/10.1158/1535-7163.22500409

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Supplementary Table 1 from Hedgehog Pathway Inhibition in Chondrosarcoma Using the Smoothened Inhibitor IPI-926 Directly Inhibits Sarcoma Cell Growth

PDF - 71K, A list of the solid tumor xenografts tested for regulation of human or murine Gli1 following IPI-926 treatment, as measured by q-RT-PCR on whole tumor RNA extracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::638ed50f91999fe61a2302b662e42782
https://doi.org/10.1158/1535-7163.22500406.v1

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Supplementary Figure 1 from Hedgehog Pathway Inhibition in Chondrosarcoma Using the Smoothened Inhibitor IPI-926 Directly Inhibits Sarcoma Cell Growth

PDF - 516K, Hh signaling in normal mouse chondrocytes is inhibited by IPI-926 treatment and leads to growth plate closure. A. Active control growth plate with a normal appearance. B. Corresponding growth plate from an IPI-926 treated mouse shows prem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44aefa78616bb576a241604483aa4a6f
https://doi.org/10.1158/1535-7163.22500415

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Supplementary Figure 2 from Hedgehog Pathway Inhibition in Chondrosarcoma Using the Smoothened Inhibitor IPI-926 Directly Inhibits Sarcoma Cell Growth

PDF - 427K, Representative image of a hematoxylin and esosin stained primary chondrosarcoma xenograft. The image shows a typical appearance of low cellularity (blue nuclei) with considerable extracellular matrix between the cells and no obvious tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702ae81a80dc902a1a4f76b5b7b3c9ac
https://doi.org/10.1158/1535-7163.22500412

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Data from Hedgehog Pathway Inhibition in Chondrosarcoma Using the Smoothened Inhibitor IPI-926 Directly Inhibits Sarcoma Cell Growth

Hedgehog (Hh) pathway inhibition in cancer has been evaluated in both the ligand-independent and ligand-dependent settings, where Hh signaling occurs either directly within the cancer cells or within the nonmalignant cells of the tumor microenvironme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a69e28631a45293ed007035d20a8495d
https://doi.org/10.1158/1535-7163.c.6536443

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Hedgehog Pathway Inhibition in Chondrosarcoma Using the Smoothened Inhibitor IPI-926 Directly Inhibits Sarcoma Cell Growth

Autor: Benjamin A. Alman, Suneel S. Apte, John Keilty, Heather Whetstone, Jennifer Proctor, Jay S. Wunder, S. Amanda Ali, Chang Ye Yale Wang, Karen McGovern, Lauren W. Wang, Qingxia Wei, Veronica Campbell, Raymond Poon, Puviindran Nadesan

Publikováno v: Molecular Cancer Therapeutics. 13:1259-1269

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddabcd3cd44e4b94a173a93171f30f72
https://doi.org/10.1158/1535-7163.mct-13-0731

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Modulating hedgehog signaling can attenuate the severity of osteoarthritis

Autor: Alvin C, Lin, Brian L, Seeto, Justyna M, Bartoszko, Michael A, Khoury, Heather, Whetstone, Louisa, Ho, Claire, Hsu, S Amanda, Ali, Amanda S, Ali, Benjamin A, Alman

Publikováno v: Nature medicine. 15(12)

Osteoarthritis is associated with the irreversible degeneration of articular cartilage. Notably, in this condition, articular cartilage chondrocytes undergo phenotypic and gene expression changes that are reminiscent of their end-stage differentiatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2736fbb8d3099d7a5e82123960e6ab88
https://pubmed.ncbi.nlm.nih.gov/20976859

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