Slowest possible replicative life at frigid temperatures for yeast

Autor: Diederik S. Laman Trip, Théo Maire, Hyun Youk

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

It is unclear what constraints exist on cellular life in frigid environments. Here, the authors demonstrate that reactive oxygen species and gene-expression speed impose a barrier to replication at low temperatures in yeast, with lower levels enablin

Externí odkaz: https://doaj.org/article/2e7b48166009463d9d7959e064e40bed

DNA origami scaffold for studying intrinsically disordered proteins of the nuclear pore complex

Autor: Philip Ketterer, Adithya N. Ananth, Diederik S. Laman Trip, Ankur Mishra, Eva Bertosin, Mahipal Ganji, Jaco van der Torre, Patrick Onck, Hendrik Dietz, Cees Dekker

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)

FG-Nups are disordered proteins in the nuclear pore complex (NPC) where they selectively control nuclear transport. Here authors build NPC-mimics based on DNA origami rings which attach a certain numbers of Nups to analyse those nanopores by cryoEM a

Externí odkaz: https://doaj.org/article/3c16edd0fd33457389226bffa28bd552

Resolving the clinico-radiological paradox in multiple sclerosis [version 1; referees: 3 approved]

Autor: Declan Chard, S Anand Trip

Publikováno v: F1000Research, Vol 6 (2017)

Understanding the clinico-radiological paradox is important in the search for more sensitive and specific surrogates of relapses and disability progression (such that they can be used to inform treatment choices in individual people with multiple scl

Externí odkaz: https://doaj.org/article/46f206f4ad0242bcb010e82bd2884d7e

Associations of Alcohol Consumption and Smoking With Disease Risk and Neurodegeneration in Individuals With Multiple Sclerosis in the United Kingdom

Autor: Iris, Kleerekooper, Sharon, Chua, Paul J, Foster, S Anand, Trip, Gordon T, Plant, Axel, Petzold, Praveen, Patel, Yalin, Zheng

Publikováno v: Kleerekooper, I, Chua, S, Foster, P J, Trip, S A, Plant, G T, UK Biobank Eye and Vision Consortium, Petzold, A & Patel, P 2022, ' Associations of Alcohol Consumption and Smoking With Disease Risk and Neurodegeneration in Individuals With Multiple Sclerosis in the United Kingdom ', JAMA network open, vol. 5, no. 3, e220902, pp. e220902 . https://doi.org/10.1001/jamanetworkopen.2022.0902
JAMA network open, 5(3):e220902. American Medical Association

Importance: Understanding the effects of modifiable risk factors on risk for multiple sclerosis (MS) and associated neurodegeneration is important to guide clinical counseling. Objective: To investigate associations of alcohol use, smoking, and obesi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cea45b0f6c0e2a2257b448a5a14b098
https://research.vumc.nl/en/publications/3cbb5c88-c5db-4533-b1b7-4dbe4a497ae6

Pattern ERGs suggest a possible retinal contribution to the visual acuity loss in acute optic neuritis

Autor: I, Kleerekooper, L, Del Porto, L, Dell'Arti, J, Guajardo, S, Leo, A G, Robson, S A, Trip, A, Petzold, G T, Plant, G E, Holder

Publikováno v: Documenta ophthalmologica. Advances in ophthalmology. 145(3)

Macular involvement in optic neuritis (ON) is well-recognised but poorly understood and may be of clinical relevance. This study explores macular structure-function correlates in acute ON.This cross-sectional cohort study recruited ON patients within

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::81b1226c4ac1f3107902759b964f1d59
https://pubmed.ncbi.nlm.nih.gov/36161379